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| 1 | Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus显示文摘Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region.Three-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone repair.Here,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG scaffolds.Moreover,MSNs sustainably released BMP-4 for long-term effectiveness.In 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory factors.BMP-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted scaffolds.Furthermore,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory microenvironment.And 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone repair.In conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2. | Xin Sun Zhenjiang Ma Xue Zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang Jinzhong Zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang | 2021 | Bioactive Materials2021，6，3： | 12 |
| 2 | Responses of Mean and Extreme Precipitation to Different Climate Forcing Under Radiative-Convective Equilibrium显示文摘Understanding the responses of mean and extreme precipitation to climate change is of great importance.Previous studies have mainly focused on the responses to prescribed sea surface warming or warming due to increases of CO2.This study uses a cloud-resolving model under the idealization of radiative-convective equilibrium to examine the responses of mean and extreme precipitation to a variety of climate forcings,including changes in prescribed sea surface temperature,CO2,solar insolation,surface albedo,stratospheric volcanic aerosols,and several tropospheric aerosols.The different responses of mean precipitation are understood by examining the changes in the surface energy budget.It is found that the cancellation between shortwave scattering and longwave radiation leads to a small dependence of the mean precipitation response on forcings.The responses of extreme precipitation are decomposed into three components(thermodynamic,dynamic,and precipitation efficiency).The thermodynamic components for all climate forcings are similar.The dynamic components and the precipitation-efficiency components,which have large spreads among the cases,are negatively correlated,leading to a small dependence of the extreme precipitation response on the forcings. | Chenyu MA Wei YUAN Ji NIE | 2020 | Advances in Atmospheric Sciences2020，37，4： | 2 |
| 3 | Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow显示文摘To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow,which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory,a coupled numerical model considering the interaction and evolution of metal elastoplastic deformation and aerodynamic pressure profile is presented.With the thermal elastoplastic constitutive relationship and failure criterion,the simulated failure modes and dynamic rupture process are basically consistent with the experimental results,indicating plastic flow and multiple fracturing is the main failure mechanism.Compared with the case of non-airflow,subsonic airflow not only accelerates deformation,but also turns the bugle deformation,plastic strain and rupture mode into asymmetric. | Xiaodong Xing Te Ma Ruixing Wang Chenyu Cao Hongwei Song Chenguang Huang | 2018 | Theoretical & Applied Mechanics Letters2018，8，4： | 2 |
| 4 | Fabrication of Regular Hierarchical Structures with Superhydrophobic and High Adhesion Performances on a 304 Stainless Steel Surface via Picosecond Laser显示文摘Hierarchical structures significantly influence the development of metal surface wettability.In this study,three kinds of hierarchical structures fbimed by the superimposition of different nanoscale(quasi-)periodic structures on micro-column arrays were fabricated on 304 stainless steel surfaces via picosecond laser irradiation.Scanning Electron Microscope(SEM)and Confocal Laser Scanning Microscope(CLSM)were used to characterize the created hierarchical structures.An optical contact angle meter was used to analyse the wetting performances.The results show that the surfaces of these fabricated samples have superhydrophobic properties and strong adhesion per formances,which can be attributed to the formation of hierarchical structure that causes a reduction in the liquid-solid contact area and the change in the direction of surfece tension.By controlling the dimensionof the nanotextures on the micro-column arrays,the hydrophobic property of 304 stainless steel surfaces can be greatly improved. | Chenbin Ma Min Kang Xingsheng Wang Ninghui Li Wei Hong Chenyu Li An Yang | 2019 | Journal of Bionic Engineering2019，16，5： | 2 |
| 5 | Functional analysis of the sbcD (dr1921) gene of the extremely radioresistant bacterium Deinococcus radiodurans显示文摘In eukaryotes, the Mre11-Rad50-Nbs1 (MRN) complex, which resides at the crossroads of DNA repair and checkpoint signaling, rapidly forms prominent foci at damage sites following double-strand break (DSB) induction. This complex carries out the initial processing of the DSB ends. Mutations in the genes that encode components of this complex result in DNA-damage hypersensitivity, genomic in- stability, telomere shortening, and aberrant meiosis. Therefore, the MR proteins are highly conserved during evolution. The bacterial orthologs of Mre11 and Rad50 are the SbcD and SbcC proteins, respec- tively. Deinococcus radiodurans, an extremely radioresistant bacterium, is able to mend hundreds of radiation-induced DSBs. The SbcD and SbcC proteins were identified as the products of the Dr1921 and Dr1922 genes. Disruption of the sbcD gene, by direct reverse-orientation insertional mutagenesis tech- nology, remarkably increases the cells’ sensitivity to various types of DNA damaging agents, such as ionizing radiation, ultraviolet irradiation, hydrogen peroxide, and mitomycin C. We also provide evidence that the drSbcD protein plays an important role in both growth and DNA repair in this organ- ism, especially in repair of DSBs generated after cellular exposure to 6000 Gy of IR. These results demonstrate that the drSbcD protein plays an important role in DSBs repair in D. radiodurans. | HU YiHuai MA ChenYu TIAN Bing LIN Jun HUA YueJin | 2007 | Chinese Science Bulletin2007，52，18： | 1 |
| 6 | Exploring the Evolution of Passenger Flow and Travel Time Reliability with the Expanding Process of Metro System Using Smartcard Data显示文摘Metro system has experienced the global rapid rise over the past decades. However,few studies have paid attention to the evolution in system usage with the network expanding. The paper's main objectives are to analyze passenger flow characteristics and evaluate travel time reliability for the Nanjing Metro network by visualizing the smart card data of April 2014,April 2015 and April 2016. We performed visualization techniques and comparative analyses to examine the changes in system usage between before and after the system expansion. Specifically,workdays,holidays and weekends were specially segmented for analysis.Results showed that workdays had obvious morning and evening peak hours due to daily commuting,while no obvious peak hours existed in weekends and holidays and the daily traffic was evenly distributed. Besides,some metro stations had a serious directional imbalance,especially during the morning and evening peak hours of workdays. Serious unreliability occurred in morning peaks on workdays and the reliability of new lines was relatively low,meanwhile,new stations had negative effects on exiting stations in terms of reliability. Monitoring the evolution of system usage over years enables the identification of system performance and can serve as an input for improving the metro system quality. | Xinwei Ma Yanjie Ji Yao Fan Chenyu Yi | 2019 | Journal of Harbin Institute of Technology(New Series)2019，26，1： | 1 |
| 7 | Molecular basis of ligand recognition and activation of human V2 vasopressin receptor显示文摘Dear Editor,Vasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR. | Fulai Zhou Chenyu Ye Xiaomin Ma Wanchao Yin Tristan I.Croll Qingtong Zhou Xinheng He Xiaokang Zhang Dehua Yang Peiyi Wang H.Eric Xu Ming-Wei Wang Yi Jiang | 2021 | Cell Research2021，31，8： | 1 |
| 8 | Gate underlap design for short channel effects control in cylindrical gate-all-around MOSFETs based on an analytical model显示文摘 | Zhang Lining Wang Shaodi Ma Chenyue | 2012 | Iete Technical Review2012，29，1： | 1 |
| 9 | A neuro-fuzzy system architecture for behavior-based control of a mobile robot in unknown environment 显示文摘 | Li Wei Ma Chenyu Wahl F M | 1997 | Fuzzy Sets and Systems1997，87，2： | 1 |
| 10 | Cause of Death among Infants in Rural Western China: A Community-Based Study Using Verbal Autopsy显示文摘 | Yi Ma Sufang Guo Huishan Wang Tao Xu Xiaona Huang Chenyue Zhao Yan Wang Robert W. Scherpbier David B. Hipgrave | 2014 | The Journal of Pediatrics2014，，： | 1 |
| 11 | Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane显示文摘It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed yet.Herein, we decouple and elaborate two distinctive pathways regarding film degradation based on FACsPbI3perovskites.Moreover, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability. | Xiao Zhang Changsu Cao Yang Bai Cheng Zhu Huachao Zai Sai Ma Yihua Chen Zhenhua Cui Congbo Shi Chenyue Wang Chenxiao Zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao Wang Huanping Zhou Hai Xiao Jun Li Qi Chen | 2022 | Science China Chemistry2022，65，11： | 0 |
| 12 | Surgical Treatment of Left Atrial Dissection and Severe Mitral Valve Obstruction显示文摘Left atrial dissection is a rare complication of mitral valve replacement surgery.Here,a case of left atrial dissection followed by mitral valvular obstruction was presented.It is suspected that the dissection was caused by trematodiases infection.Cardiac surgery was finally performed,which not only confirmed the diagnosis but also acted as an effective treatment.Especially,surgery is of essential value to confirm the perforation locating at the basal posterior wall of the left ventricle,to repair the atrial dissection,and to relieve the mitral valvular obstruction. | Antian Chen Guotao Ma Deyan Yang Chenyu Wang Yingxian Liu | 2021 | Cardiology Discovery2021，1，2： | 0 |
| 13 | In Situ Scattering Studies of Crystallization Kinetics in a Phase-Separated Zr-Cu-Fe-Al Bulk Metallic Glass显示文摘Thermal stability and the crystallization kinetics of a phase-separated Zr-Cu-Fe-Al bulk metallic glass were investigated using in situ high-energy synchrotron X-ray and neutron diffraction,as well as small-angle synchrotron X-ray scattering.It was revealed that this glass with excellent glass-forming ability possesses a two-step crystallization behavior.The crystalline products and their evolution sequence are more complicated than a homogeneous Zr-Cu-Al glass with average glass-forming ability.The experimental results indicate that a finely distributed nanometer-sized cubic Zr_(2)Cu phase forms first and then transforms to a tetragonal Zr_(2)Cu phase,while the matrix transforms to an orthorhombic Zr_(3)Fe phase.The strength of the Zr-Cu-Fe-Al composite containing cubic Zr_(2)Cu phase and glass matrix increases,and the plasticity also improves compared to the as-cast Zr-Cu-Fe-Al bulk metallic glass.Our results suggest that the formation of multiple and complex crystalline products would be the characteristics of the Zr-Cu-Fe-Al glass with better glass-forming ability.Our study may shed light on the synthesis of bulk-sized glass-nanocrystals composites of high strength and good plasticity. | Sinan Liu Jiacheng Ge Huiqaing Ying Chenyu Lu Dong Ma Xun-Li Wang Xiaobing Zuo Yang Ren Tao Feng Jun Shen Horst Hahn Si Lan | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 14 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 15 | Preparation and Characterization of 3D Printed Hydroxyapatite-Whisker-Strengthened Hydroxyapatite Scaffold Coated with Biphasic Calcium Phosphate显示文摘This study investigates the in vitro degradation of calcium-deficient hydroxyapatite powder after heat treatment at different temperatures and analyzes the calculated phase composition,particle size distribution,degradation rate,and bioactivity of the powder after heat treatment.A mixture of hydroxyapatite and��-tricalcium phosphate(BCP)coatings was prepared on the surface of a 3D-printed hydroxyapatite-whisker-strengthened hydroxyapatite scaf-fold(HAw/HA)by vacuum impregnation and ultraviolet light curing combined with an optimized heat treatment process.The performance of the coatings under different methods was characterized.The composite scaffolds with highly interconnected pores and excellent mechanical properties were prepared,and their biodegradation performance,bioactivity,osteoconductivity,and osteoinductivity of the scaffolds were improved.The results showed that calcium-deficient hydroxyapatite began to transform into BCP between 600℃and 800℃,and the powder treated at 800℃has better bioactivity.The BCP coating prepared by light curing was more uniform,resulting in a higher interfacial bonding strength,and has better osteoconductivity and osteoinductivity than that prepared by vacuum impregnation. | Chenyu Ma Qingfeng Zeng Luwang Yu Shuyin Yu Jiayin Song Yongjie Ma Xieping Dong | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 16 | Protective effects and mechanisms of Lizhong decoction(理中汤) against non-alcoholic fatty liver disease in a rat model显示文摘OBJECTIVE: To investigate the protective effects and molecular mechanisms of Lizhong decoction( 理中汤, LZD) against non-alcoholic fatty liver disease(NAFLD). METHODS: Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD, and were administered LZD by gavage for four weeks. Potential therapeutic targets for NAFLD were analyzed using network pharmacology. Liver pathology was evaluated using Oil Red O and hematoxylin-eosin staining. Furthermore, mitochondrial function, lipid metabolism, oxidative stress, and inflammatory response were examined. RESULTS: Rats with NAFLD exhibited high levels of hepatic damage and cholesterol deposition. Moreover, apoptosis was increased, superoxide dismutase and glutathione content were reduced, malondialdehyde content was increased, and the protein expression of inflammatory cytokines and p-c-Jun N-terminal kinase was increased. The LZD treatment ameliorated mitochondrial dysfunction, reduced liver damage,inhibited oxidative stress and inflammatory response, upregulated peroxisome proliferator-activated receptor(PPAR)-γ expression, and suppressed dipeptidyl peptidase 4(DPP4) expression in the liver. CONCLUSION: It was found that LZD alleviates NAFLD by activating PPAR-γ and inhibiting DPP4. | YANG Jiayao TAO Dongqing MA Wei LIU Song LIAO Yan SHU Lei ZHANG Shu LI Chenyu DU Nianlong | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 17 | 加芪合剂对荷瘤小鼠放射治疗的辅助作用(英文)显示文摘Objective:The aim was to study the assistant radiotherapeutic effect of Jiaqi Mixture (JQM) on Ehrlich's ascites carcinoma (EAC) mice.Methods:The EAC-cancer model was made up with Kunming mice.The tumor-bearing mice were treated with whole body exposure (8 Gy) and intragastric administration of JQM,and the changes of tumor weight,the total number of white blood cells (WBC) and immune system were observed.Results:The average tumor weight,WBC,spleen coefficient,the stimulation index (SI) of Con A and LPS and the natural killing (NK) cell activity of mice decreased in some degree after radiotherapy,but the average tumor weight decreased more obviously in radiotherapy + medicine groups (compared with tumor control group,P < 0.05);and the other above indexes were much higher in radiotherapy + medicine groups than those in radiotherapy groups (P < 0.05-0.01).Conclusion:It was suggested that JQM can enhance the effect of radiation therapy and protect the normal immune system caused by radiation therapy. | Shichao Wei Chenyu Zhang Guang Du Baoxia Ma | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 18 | Multidimensional Visualization of Bikeshare Travel Patterns Using a Visual Data Mining Technique: Data Cubes显示文摘In order to explore the travel characteristics and space-time distribution of different groups of bikeshare users,an online analytical processing(OLAP)tool called data cube was used for treating and displaying multi-dimensional data.We extended and modified the traditionally threedimensional data cube into four dimensions,which are space,date,time,and user,each with a user-specified hierarchy,and took transaction numbers and travel time as two quantitative measures.The results suggest that there are two obvious transaction peaks during the morning and afternoon rush hours on weekdays,while the volume at weekends has an approximate even distribution.Bad weather condition significantly restricts the bikeshare usage.Besides,seamless smartcard users generally take a longer trip than exclusive smartcard users;and non-native users ride faster than native users.These findings not only support the applicability and efficiency of data cube in the field of visualizing massive smartcard data,but also raise equity concerns among bikeshare users with different demographic backgrounds. | Xinwei Ma Yanjie Ji Yang Liu Yuchuan Jin Chenyu Yi | 2019 | Journal of Beijing Institute of Technology2019，28，2： | 0 |
| 19 | Model of NBTI combined with mobility degradation显示文摘The mobility degradation induced by negative bias temperature instability(NBTI) is usually ignored in traditional NBTI modeling and simulation, resulting in overestimation of the circuit lifetime, especially after longterm operation. In this paper, the mobility degradation is modeled in combination with the universal NBTI model.The coulomb scattering induced by interface states is revealed to be the dominant component responsible for mobility degradation. The proposed mobility degradation model fits the measured data well and provides an accurate solution for evaluating coupling of NBTI with HCI(hot carrier injection) and SHE(self-heating effect), which indicates that mobility degradation should be considered in long-term circuit aging simulation. | Xuezhong Wu Chenyue Ma Shucheng Gao Xiangbin Li Fu Sun Lining Zhang Xinnan Lin | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 20 | The Importance of Food Security from the Perspective of Food Issue of the Roman Empire显示文摘This paper firstly introduced characteristics of the food production( or grain production) and regulation of the prosperous period of the Roman Empire. Then,it discussed the shortcomings and summarized the experience and lessons. It is expected to provide some references for construction of China's food security. | Lianjing MA Chenyu WANG | 2017 | Asian Agricultural Research2017，9，9： | 0 |
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