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| 1 | Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China,India and the US using simple sequence repeat markers显示文摘Cultivated peanut is grown worldwide as richsource of oil and protein. A broad genetic base is needed for cultivar improvement. The objectives of this study were to develop highly informative simple sequence repeat(SSR)markers and to assess the genetic diversity and population structure of peanut cultivars and breeding lines from different breeding programs in China, India and the US. A total of 111 SSR markers were selected for this study, resulting in a total of 472 alleles. The mean values of gene diversity and polymorphic information content(PIC) were 0.480 and 0.429, respectively.Country-wise analysis revealed that alleles per locus in three countries were similar. The mean gene diversity in the US,China and India was 0.363, 0.489 and 0.47 with an average PIC of 0.323, 0.43 and 0.412, respectively. Genetic analysis using the STRUCTURE divided these peanut lines into two populations(P_1, P_2), which was consistent with the dendrogram based on genetic distance(G_1, G_2) and the clustering of principal component analysis. The groupings were related to peanut market types and the geographic origin with a few admixtures. The results could be used by breeding programs to assess the genetic diversity of breeding materials to broaden the genetic base and for molecular genetics studies. | Hui Wang Pawan Khera Bingyan.Huang Mei Yuan Ramesh Katam Weijian Zhuang Karen Harris-Shultz Kim M.Moore Albert K.Culbreath Xinyou Zhang Rajeev K.Varshney Lianhui Xie Baozhu Guo | 2016 | Journal of Integrative Plant Biology2016，58，5： | 2 |
| 2 | Epstein-Barr病毒特异性T细胞对重组痘苗病毒表达LMP和EBNA2的靶细胞的识别显示文摘本文用EB病毒转化自体淋巴细胞所建立的类淋巴母细胞系(LCL),以及用EB病毒潜伏感染膜蛋白(LMP)基因和核蛋白-2(EBNA2)基因与痘苗病毒重组的重组病毒(Vac-LMP和Vac-EBNA2)感染的自身纤维母细胞,同时作为刺激细胞和靶细胞,以^(51)Cr释放法检测5例血清中EB病毒VCA—IgA抗体阳性者及1例阴性健康者外周血单个核细胞(PBMC)的特异性T细胞杀伤效应。结果表明,用自身LCL激活的EB病毒特异性T细胞杀伤效应高峰出现在第14~28天;参与杀伤性细胞免疫反应的T细胞亚群主要是T3、T8阳性的细胞毒性T细胞,其对靶细胞的识别及杀伤受HLA-I的限制。用重组牛痘病毒感染的纤维母细胞作靶细胞或刺激细胞,有1例供者可接受LMP,另1例可接受EBNA2的刺激,并对相应的靶细胞产生特异性T细胞杀伤反应,表明EB病毒-LMP和EBNA2可能既是EB病毒特异性T细胞的刺激抗原,又是其识别的靶抗原。 | 陈小毅 A.Ghosh M.Moore John Arrand | 1991 | 病毒学报1991，7，2： | 2 |
| 3 | Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000显示文摘 | Martha M.Moore MasamitsuHonma JulieClements KarenHarrington‐Brock TakumiAwogi GeorgeBolcsfoldi MariaCifone DeborahCollard MichaelFellows KathrynFlanders BhaskarGollapudi PeterJenkinson PaulKirby StephanKirchner JoannKraycer StephenMcEnaney WolfgangMuster | 2002 | Environ Mol Mutagen2002，，4： | 1 |
| 4 | Contribution of epididymal factors to sperm maturation and storage显示文摘 | H. D. M.Moore | 2009 | Andrologia (鈥?)2009，，4： | 1 |
| 5 | The dynamics of error growth and predictability in a coupled model of ENSO显示文摘 | Andrew M.Moore RichardKleeman | 2006 | QJR Meteorol Soc2006，，534： | 1 |
| 6 | 加拿大2个不整合面型金矿床的地球化学和成因显示文摘Addington和Ore Chimney是元古代含金石英一碳酸盐脉矿床,它们产在较低级的角闪岩相变质岩中,在一较大的区域性不整合面上或其附近。 Ore Chimney矿床是一典型的不透明的矿物组合——方铅矿-闪锌矿-黄铁矿-黄铜矿-磁黄铁矿-富银黝铜矿-钛铁矿。脉系赋存在一厚4m的黑云母片岩中,此黑云母片岩周围为变玄武熔岩流。变火山岩之上不整合地覆盖着厚10m的变泥质石榴石-黑云母片岩(Ore Chimney建造)和一粗的硅质碎屑岩(Flinton组).Ore Chimney矿床出现在不整合面之下30m处。 Addington矿床具有典型的不透明的毒砂-黄铁矿-黄铜矿-磁黄铁矿-钛铁矿的矿物群。这个矿床赋存在Ore Chimney建造内,并位于沿走向距Ore Chimney矿山8km处。毒砂地温测量和闪锌矿地压测量获得温度和压力,估计范围分别为420—530℃和0.35—0.59GPa,与估计的顶峰变质条件是一致的。地球化学、结构和构造证据表明,脉建造和矿化是在主变质和变形幕期间发生的,金是经由变质流体而沉积的.矿化作用与围岩的弱碳酸盐化有关。金和贱金属可以从热液和/或风化作用生成早期浓度中重新活动。 | Luc Harnois John M.Moore 严平兴 | 1992 | 国外铀金地质1992，，3： | 0 |
| 7 | EB病毒特异性T细胞克隆的建立及其对不同浓度重组白细胞介素-2的反应显示文摘以辐射灭活的EB病毒类淋巴母细胞株作为刺激抗原,培养液中加入10%MLA-144上清液(含IL-2),用限制性稀释法建立EB病毒特异性T细胞克隆.在用含不同浓度的重组IL-2(rIL-2)培养后,检测T细胞克隆特性的改变,结果显示,特异性T细胞克隆的建立依赖于特异性抗原的刺激及少量IL-2的存在.T细胞克隆形成后,其特异性、HLA限制性及T细胞表型等特性是相对稳定的,不受培养液中rIL-2浓度变化的影响. | 陈小毅 A.K Ghosh M.Moore | 1991 | 广东医学院学报1991，0，1： | 0 |
| 8 | Cannabinoids function in defense against chewing herbivores in Cannabis sativa L.显示文摘In the decades since the first cannabinoids were identified by scientists,research has focused almost exclusively on the function and capacity of cannabinoids asmedicines and intoxicants for humans and other vertebrates.Very little is knownabout the adaptive value of cannabinoid production,though several hypotheses have been proposed including protection from ultraviolet radiation,pathogens,and herbivores.To test the prediction that genotypeswith greater concentrations of cannabinoidswill have reduced herbivory,a segregating F2 population of Cannabis sativa was leveraged to conduct lab-and field-based bioassays investigating the function of cannabinoids in mediating interactions with chewing herbivores.In the field,foliar cannabinoid concentration was inversely correlated with chewing herbivore damage.On detached leaves,Trichoplusia ni larvae consumed less leaf area and grew less when feeding on leaves with greater concentrations of cannabinoids.Scanning electron and light microscopy were used to characterize variation in glandular trichome morphology.Cannabinoid-free genotypes had trichomes that appeared collapsed.To isolate cannabinoids from confounding factors,artificial insect diet was amended with cannabinoids in a range of physiologically relevant concentrations.Larvae grew less and had lower rates of survival as cannabinoid concentration increased.These results support the hypothesis that cannabinoids function in defense against chewing herbivores. | George M.Stack Stephen I.Snyder Jacob A.Toth Michael A.Quade Jamie L.Crawford John K.McKay John Nicholas Jackowetz Ping Wang Glenn Philippe Julie L.Hansen Virginia M.Moore Jocelyn K.C.Rose Lawrence B.Smart | 2023 | Horticulture Research2023，10，11： | 0 |
| 9 | Shunting,optic nerve sheath fenestration and dural venous stenting for medically refractory idiopathic intracranial hypertension:systematic review and meta-analysis显示文摘Background:Cerebrospinal fluid(CSF)-diversion procedures have traditionally been the standard of treatment for patients with medically refractive idiopathic intracranial hypertension(IIH).However,dural venous sinus stent(VSS)placement has been described as a safe and effective procedure for the management of medically refractive IIH.We performed a meta-analysis comparing outcomes and complications of CSF-diversion procedures,VSS and optic nerve sheath fenestration(ONSF)for the treatment of medically refractive IIH.Methods:Electronic searches were performed using six databases from 1988 to January 2017.Data was extracted and meta-analysed from the identified studies.Results:From 55 pooled studies,there were 538 CSF-diversion cases,224 dural venous stent placements,and 872 ONSF procedures.Similar improvements were found in terms of postoperative headaches(CSF vs.VSS vs.ONSF:84%vs.78%vs.62%,P=0.223),papilledema(CSF vs.VSS vs.ONSF:71%vs.86%vs.77%,P=0.192),whilst visual acuity changes favored venous stenting(CSF vs.VSS vs.ONSF:55%vs.69%vs.44%,P=0.037).There was a significantly lower rate of subsequent procedures with venous stent placement(CSF vs.VSS vs.ONSF:37%vs.13%vs.18%,P<0.001),but other complication rates were similar(CSF vs.VSS vs.ONSF:13%vs.8%vs.14%,P=0.28).Subgroup analysis of lumbar-peritoneal vs.ventriculoperitoneal shunts found no differences in symptom improvements,complications and subsequent procedure rates.Conclusions:Our findings suggest that dural venous sinus stenting may be a viable alternative to traditional surgical interventions in patients who are refractory to medical treatment. | Daniel B.Scherman Adam A.Dmytriw Gia Thanh Nguyen Nhan Thi Nguyen Nana Tchantchaleishvili Julian Maingard Hamed Asadi Mark Brooks Christoph Griessenauer Christopher Ogilvy Ajith J.Thomas Justin M.Moore Kevin Phan | 2018 | Annals of Eye Science2018，，1： | 0 |
| 10 | The role of emergency incident type in identifying first responders' health exposure risks显示文摘Fire-based emergency management service(EMS)personnel are dispatched to various incidents daily,many of which have unique occupational risks.To fully understand the variability of incident types and how to best pre-pare and respond,an exploration of the U.S.coding system of incident types is necessary.This study uses potential exposure to SARS-CoV-2 as a case example to understand if and how coding categories for incident call types may be updated to improve data standardization and emergency response decision making.Researchers received emergency response incident data generated by three fire department computer-aided dispatch(CAD)systems between March and September 2020.Each incident was labeled EMS,Fire,or Other.Of the 162,766 incidents,approximately 8.1%(n=13,144)noted potential SARS-CoV-2 exposure within their narrative descriptions of which 86.3%were coded as EMS,9.9%as Fire,and 3.9%as Other.To assess coding variability across incident types,researchers used the original 3-incident type variable and a new 5-incident type variable reassigned by researchers into EMS,Fire,Other,Hazmat,and Motor Vehicle.Logit regressions compared differences in potential exposure using the 3-and 5-incident type variables.When evaluating the 3-incident type variable,those respond-ing to a Fire versus an EMS incident were 84%less likely to be associated with potential exposure to SARS-Cov-2.For the 5-incident type variable,those responding to Fire incidents were 77%less likely to be associated with a potential exposure than those responding to EMS incidents.Changes in potential exposure between the 3-and 5-incident type models show the need to understand how incident types are assigned.This demonstrates the need for data standardization to accurately categorize incident types to improve emergency preparedness and response.Results have implications for incident type coding at fire department municipality and national levels. | Emily J.Haas Katherine N.Yoon Alexa Furek Megan Casey Susan M.Moore | 2023 | Journal of Safety Science and Resilience2023，4，2： | 0 |
| 11 | The proteome of distal nerves: implication in delayed repair and poor functional recovery显示文摘Chronic denervation is one of the key factors that affect nerve regeneration.Chronic axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for regeneration.Some of these factors/proteins have been individually studied.To better delineate the comprehensive protein expression profiles and identify proteins that contribute to or are associated with this detrimental effect,we carried out a proteomic analysis of the distal nerve using an established delayed rat sciatic nerve repair model.Four rats that received immediate repair after sciatic nerve transection served as control,whereas four rats in the experimental group(chronic denervation)had their sciatic nerve repaired after a 12-week delay.All the rats were sacrificed after 16 weeks to harvest the distal nerves for extracting proteins.Twenty-five micrograms of protein from each sample were fractionated in SDS-PAGE gels.NanoLC-MS/MS analysis was applied to the gels.Protein expression levels of nerves on the surgery side were compared to those on the contralateral side.Any protein with a P value of less than 0.05 and a fold change of 4 or higher was deemed differentially expressed.All the differentially expressed proteins in both groups were further stratified according to the biological processes.A PubMed search was also conducted to identify the differentially expressed proteins that have been reported to be either beneficial or detrimental to nerve regeneration.Ingenuity Pathway Analysis(IPA)software was used for pathway analysis.The results showed that 709 differentially expressed proteins were identified in the delayed repair group,with a bigger proportion of immune and inflammatory process-related proteins and a smaller proportion of proteins related to axon regeneration and lipid metabolism in comparison to the control group where 478 differentially expressed proteins were identified.The experimental group also had more beneficial proteins that were downregulated and more detrimental proteins that were upregulated.IPA revealed that protective pathways such as LXR/RXR,acute phase response,RAC,ERK/MAPK,CNTF,IL-6,and FGF signaling were inhibited in the delayed repair group,whereas three detrimental pathways,including the complement system,PTEN,and apoptosis signaling,were activated.An available database of the adult rodent sciatic nerve was used to assign protein changes to specific cell types.The poor regeneration seen in the delayed repair group could be associated with the down-regulation of beneficial proteins and up-regulation of detrimental proteins.The proteins and pathways identified in this study may offer clues for future studies to identify therapeutic targets. | Song Guo Raymond M.Moore M.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang | 2022 | Neural Regeneration Research2022，17，9： | 0 |
| 12 | Agrobacterium tumefaciens: A Bacterium Primed for Synthetic Biology显示文摘Agrobacterium tumefaciens is an important tool in plant biotechnology due to its natural ability to transfer DNA into the genomes of host plants.Genetic manipulations of A.tumefaciens have yielded considerable advances in increasing transformational efficiency in a number of plant species and cultivars.Moreover,there is overwhelming evidence that modulating the expression of various mediators of A.tumefaciens virulence can lead to more successful plant transformation;thus,the application of synthetic biology to enable targeted engineering of the bacterium may enable new opportunities for advancing plant biotechnology.In this review,we highlight engineering targets in both A.tumefaciens and plant hosts that could be exploited more effectively through precision genetic control to generate high-quality transformation events in a wider range of host plants.We then further discuss the current state of A.tumefaciens and plant engineering with regard to plant transformation and describe how future work may incorporate a rigorous synthetic biology approach to tailor strains of A.tumefaciens used in plant transformation. | Mitchell G.Thompson William M.Moore Niklas F.C.Hummel Allison N.Pearson Collin R.Barnum Henrik V.Scheller Patrick M.Shih | 2020 | BioDesign Research2020，，1： | 0 |
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