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| 1 | Biosystems Design to Accelerate C3-to-CAM Progression显示文摘Global demand for food and bioenergy production has increased rapidly,while the area of arable land has been declining for decades due to damage caused by erosion,pollution,sea level rise,urban development,soil salinization,and water scarcity driven by global climate change.In order to overcome this conflict,there is an urgent need to adapt conventional agriculture to water-limited and hotter conditions with plant crop systems that display higher water-use efficiency(WUE).Crassulacean acid metabolism(CAM)species have substantially higher WUE than species performing C3 or C4 photosynthesis.CAM plants are derived from C3 photosynthesis ancestors.However,it is extremely unlikely that the C3 or C4 crop plants would evolve rapidly into CAM photosynthesis without human intervention.Currently,there is growing interest in improving WUE through transferring CAM into C3 crops.However,engineering a major metabolic plant pathway,like CAM,is challenging and requires a comprehensive deep understanding of the enzymatic reactions and regulatory networks in both C3 and CAM photosynthesis,as well as overcoming physiometabolic limitations such as diurnal stomatal regulation.Recent advances in CAM evolutionary genomics research,genome editing,and synthetic biology have increased the likelihood of successful acceleration of C3-to-CAM progression.Here,we first summarize the systems biology-level understanding of the molecular processes in the CAM pathway.Then,we review the principles of CAM engineering in an evolutionary context.Lastly,we discuss the technical approaches to accelerate the C3-to-CAM transition in plants using synthetic biology toolboxes. | Guoliang Yuan MdMahmudul Hassan Degao Liu Sung Don Lim Won Cheol Yim John C.Cushman Kasey Markel Patrick M.Shih Haiwei Lu David J.Weston Jin-Gui Chen Timothy J.Tschaplinski Gerald A.Tuskan Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 0 |
| 2 | Plant Biosystems Design Research Roadmap 1.0显示文摘Human life intimately depends on plants for food,biomaterials,health,energy,and a sustainable environment.Various plants have been genetically improved mostly through breeding,along with limited modification via genetic engineering,yet they are still not able to meet the ever-increasing needs,in terms of both quantity and quality,resulting from the rapid increase in world population and expected standards of living.A step change that may address these challenges would be to expand the potential of plants using biosystems design approaches.This represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological systems.Plant biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant genomes.From this perspective,we present a comprehensive roadmap of plant biosystems design covering theories,principles,and technical methods,along with potential applications in basic and applied plant biology research.We highlight current challenges,future opportunities,and research priorities,along with a framework for international collaboration,towards rapid advancement of this emerging interdisciplinary area of research.Finally,we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception,trust,and acceptance. | Xiaohan Yang June I.Medford Kasey Markel Patrick M.Shih Henrique C.De Paoli Cong T.Trinh Alistair J.McCormick Raphael Ployet Steven G.Hussey Alexander A.Myburg Poul Erik Jensen Md Mahmudul Hassan Jin Zhang Wellington Muchero Udaya C.Kalluri Hengfu Yin Renying Zhuo Paul E.Abraham Jin-Gui Chen David J.Weston Yinong Yang Degao Liu Yi Li Jessy Labbe Bing Yang Jun Hyung Lee Robert W.Cottingham Stanton Martin Mengzhu Lu Timothy J.Tschaplinski Guoliang Yuan Haiwei Lu Priya Ranjan Julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan | 2020 | BioDesign Research2020，，1： | 0 |
| 3 | Agrobacterium tumefaciens: A Bacterium Primed for Synthetic Biology显示文摘Agrobacterium tumefaciens is an important tool in plant biotechnology due to its natural ability to transfer DNA into the genomes of host plants.Genetic manipulations of A.tumefaciens have yielded considerable advances in increasing transformational efficiency in a number of plant species and cultivars.Moreover,there is overwhelming evidence that modulating the expression of various mediators of A.tumefaciens virulence can lead to more successful plant transformation;thus,the application of synthetic biology to enable targeted engineering of the bacterium may enable new opportunities for advancing plant biotechnology.In this review,we highlight engineering targets in both A.tumefaciens and plant hosts that could be exploited more effectively through precision genetic control to generate high-quality transformation events in a wider range of host plants.We then further discuss the current state of A.tumefaciens and plant engineering with regard to plant transformation and describe how future work may incorporate a rigorous synthetic biology approach to tailor strains of A.tumefaciens used in plant transformation. | Mitchell G.Thompson William M.Moore Niklas F.C.Hummel Allison N.Pearson Collin R.Barnum Henrik V.Scheller Patrick M.Shih | 2020 | BioDesign Research2020，，1： | 0 |
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