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| 1 | NOTUM inhibition increases endocortical bone formation and bone strength显示文摘The disability,mortality and costs caused by non-vertebral osteoporotic fractures are enormous.Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures.Cortical bone is a major determinant of non-vertebral bone strength.To identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes.Cortical bone thickness was substantially elevated in Notum?/?mice.NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts.Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed.They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation.Thus,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures. | Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu | 2019 | Bone Research2019，7，1： | 2 |
| 2 | The hidden lifestyles of Bacillus cereus and relatives显示文摘 | G. B.Jensen B. M.Hansen J.Eilenberg J.Mahillon | 2003 | Environmental Microbiology2003，，8： | 1 |
| 3 | Are monitoring and evaluation systems adequate to report the programmatic coverage of HIV services among key populations in countries?显示文摘There was no global guidance or agreement regarding when a country has an adequate system to report on the service packages among human immunodeficiency virus(HIV)key populations.This article describes an approach to categorizing the system in a country for reporting the service package among HIV key populations.The approach consists of four dimensions,namely the epidemiological significance,comprehensiveness of the service packages,geographic coverage of services,and adequacy of the monitoring system.The proposed categorization approach utilizes available information and can inform the improvement of the service delivery and monitoring systems among HIV key populations. | Jinkou Zhao Sonia Arias Garcia Ed Ngoksin Jesus Maria Garcia Calleja Chinelo Ogbuanu Sandra Kuzmanovska Nicholas Oliphant David Lowrance Nathalie Zorzi Peter M.Hansen Keith Sabin | 2019 | Infectious Diseases of Poverty2019，8，4： | 1 |
| 4 | The Relationship Be-tween Corporate Social Responsibility and Shareholder Value:An Empirical Test of the Risk Management Hypothesis显示文摘 | Paul C.Godfrey Craig B.Merrill Jared M.Hansen | | 0，，： | 1 |
| 5 | Competence resource specialization,causal ambiguity,and the creation and decay of competitiveness:the role of marketing strategy in new product performance and shareholder value显示文摘 | Jared M.Hansen Robert E.McDonald Ronald K.Mitchell | | 0，，： | 1 |
| 6 | Effects of Aronia polyphenols on the physico-chemical properties of whey,soy,and pea protein isolate dispersions显示文摘Bioactive compounds including polyphenols(PP)have been observed to naturally form non-covalent complexation interactions with proteins under mild pH and temperature conditions,affecting protein structures and functionality.Previously,addition of Aronia berry PP to liquid dispersions containing whey protein isolate(WPI)and sucrose was found to alter characteristics including viscosity,surface tension,and particle sizes,with changes being attributed to protein-PP interactions.In this study we aimed to investigate whether Aronia PP would interact with soy and pea protein isolates(SPI and PPI,respectively)to a similar extent as with WPI in liquid protein-sucrose-PP mixtures.We hypothesized that formulations containing PPI(comprised of larger proteins)and hydrolyzed SPI(containing more carboxyl groups)may exhibit increased viscosities and decreased aggregate sizes due to enhanced protein-PP interactions.Concentrated liquid dispersions of varied ratios of protein to sucrose contents,containing different protein isolates(WPI,SPI,and PPI),and varied Aronia PP concentrations were formulated,and physical properties were evaluated to elucidate the effects of PP addition.PP addition altered physical characteristics differently depending on the protein isolate used,with changes attributed to protein-PP interactions.SPI and PPI appeared to have higher propensities for PP interactions and exhibited more extensive shifts in physical properties than WPI formulations.These findings may be useful for practical applications such as formulating products containing fruit and proteins to obtain desirable sensory attributes. | Mackenzie M.Hansen Richard W.Hartel Yrjö H.Roos | 2021 | Food Production, Processing and Nutrition2021，3，1： | 0 |
| 7 | Bioactives and extracts affect the physico-chemical properties of concentrated whey protein isolate dispersions显示文摘Non-covalent complexation interactions are known to occur between bioactive compounds and proteins. While formulating with these components can have positive outcomes such as stabilization of colors and actives, it can also result in changes to the structures and physical properties of proteins, affecting product functionality and sensory attributes. Previous experiments reported measurable changes in the physico-chemical properties of whey protein isolate (WPI) dispersions upon formulation with Aronia berry extract, ascribing changes to protein-polyphenol (PP) interactions in the systems. Pure gallotannin, beet extract, and cranberry extract, providing a diverse variety structures and sizes, were selected for further experimentation and comparison with the effects of Aronia extract. Concentrated dispersions with varying WPI:sucrose ratios, formulated with several bioactives contents from multiple different sources were analyzed to identify the effects of different bioactives on physico-chemical properties of dispersions. Dispersions formulated with cranberry extract demonstrated the largest increases in surface tensions, viscosities, and particle sizes, while those formulated with beet extract were the least affected by the presence of bioactives, suggesting that different bioactives and extracts had varying propensities for complexation interactions with WPI, despite their relatively low levels of addition (0, 0.5, and 1%). | Mackenzie M.Hansen Richard W.Hartel YrjöH.Roos | 2022 | Food Production, Processing and Nutrition2022，4，1： | 0 |
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