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2篇 您的检索式：作者名="Peter M.Hansen"

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		题名	作者	年代	出处	被引量
	1	NOTUM inhibition increases endocortical bone formation and bone strength显示文摘The disability,mortality and costs caused by non-vertebral osteoporotic fractures are enormous.Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures.Cortical bone is a major determinant of non-vertebral bone strength.To identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes.Cortical bone thickness was substantially elevated in Notum?/?mice.NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts.Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed.They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation.Thus,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.	Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu	2019	Bone Research2019，7，1：	2
	2	Are monitoring and evaluation systems adequate to report the programmatic coverage of HIV services among key populations in countries?显示文摘There was no global guidance or agreement regarding when a country has an adequate system to report on the service packages among human immunodeficiency virus(HIV)key populations.This article describes an approach to categorizing the system in a country for reporting the service package among HIV key populations.The approach consists of four dimensions,namely the epidemiological significance,comprehensiveness of the service packages,geographic coverage of services,and adequacy of the monitoring system.The proposed categorization approach utilizes available information and can inform the improvement of the service delivery and monitoring systems among HIV key populations.	Jinkou Zhao Sonia Arias Garcia Ed Ngoksin Jesus Maria Garcia Calleja Chinelo Ogbuanu Sandra Kuzmanovska Nicholas Oliphant David Lowrance Nathalie Zorzi Peter M.Hansen Keith Sabin	2019	Infectious Diseases of Poverty2019，8，4：	1

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