|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 三维全扫描荧光法探讨长江口邻近陆架有机沉积物来源显示文摘近年发展起来的三维全扫描荧光光谱主要由硬件PE650—40荧光分光计,PE—3600数据站和PE—660打印画图机和专用“SCANR”软件组成.激发和发射波长分别在220—600nm范围内进行全自动,交替,连续地扫描,以发射/激发波长和荧光强度的三维全扫描荧光光谱图,以及它们的等高线图来描述测量结果,用该项新技术研究东海长江口海域表层沉积物中多环芳炷浓度和它们的环数分布特征,还讨论了具有典型陆源高等植物特征的苝的浓度分布特征,结果表明沉积物中有机质主要来自长江入海陆源物随远离河口递减,在东经123°以西附近出现最高浓度值. | 朱桂海 Jame M.Brooks | 1989 | 沉积学报1989，7，1： | 3 |
| 2 | Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig显示文摘 | E. M.Krauter D. S.Strong E. M.Brooks D. R.Linden K. A.Sharkey G. M.Mawe | 2007 | Neurogastroenterology & Motility2007，，12： | 2 |
| 3 | 三维全扫描荧光光谱在海洋石油勘探中的应用显示文摘 | 朱桂海 Jame M.Brooks | 1987 | 石油实验地质1987，，03： | 1 |
| 4 | 三维全扫描荧光光谱在海洋石油勘探中的应用显示文摘 | 朱桂海 Jame M.Brooks | 1987 | 石油实验地质1987，，03： | 1 |
| 5 | Applied biodiversity science in China in the global context显示文摘In 2021,the city of Kunming in Yunnan Province,China,will host the fifteenth meeting of Conference of Parties of the Convention on Biological Diversity.The meeting is expected to be the pivotal moment at which the world's governments agree on a new Tost-2020 Global Biodiversity Framework'(http://gffzza9a1e4a481d543d7sf9ocpf6vx9cc6p0f.ffgz.tsg.suse.edu.cn/conferences/post2020).The framework is anticipated to be structured around a small number of outcome goals for 2050-a compelling case has been made that these should include explicitgoals for ecosystems,species,genetic diversity and the contributions which nature makes to people[1]. | Thomas M.Brooks Xinsheng Zhang | 2021 | National Science Review2021，8，7： | 0 |
| 6 | EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid显示文摘Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. Methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, Montreal Cognitive Assessment [MoCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and MOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal older adults is associated with neuronal hyperexcitability. The decreased P3 task difference likely reflects early impairments in working memory processes. Further research is warranted to determine the validity of ERP in predicting clinical, neurobiological, and functional manifestations of AD. | Hannes Devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan D.Mahnken William M.Brooks Jeffrey M.Burns | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 7 | Bioproduced Proteins On Demand(Bio-POD)in hydrogels using Pichia pastoris显示文摘Traditional production of industrial and therapeutic proteins by eukaryotic cells typically requires large-scale fermentation capacity.As a result,these systems are not easily portable or reusable for on-demand protein production applications.In this study,we employ Bioproduced Proteins On Demand(Bio-POD),a F127-bisurethane methacrylate hydrogel-based technique that immobilizes engineered Pichia pastoris for preservable,on-demand production and secretion of medium-and high-molecular weight proteins(in this case,SEAP,α-amylase,and anti-HER2).The gel samples containing encapsulated-yeast demonstrated sustained protein production and exhibited productivity immediately after lyophilization and rehydration.The hydrogel platform described here is the first hydrogel immobilization using a P.pastoris system to produce recombinant proteins of this breadth.These results highlight the potential of this formulation to establish a cost-effective bioprocessing strategy for on-demand protein production. | Shuo-Fu Yuan Sierra M.Brooks Annalee W.Nguyen Wen-Ling Lin Trevor G.Johnston Jennifer A.Maynard Alshakim Nelson Hal S.Alper | 2021 | Bioactive Materials2021，6，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员