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| 1 | Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article显示文摘Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease. | Marco Aurélio Lumertz Saffi Mariana Vargas Furtado Carisi Anne Polanczyk Márlon Munhoz Montenegro Ingrid Webb Josephson Ribeiro Cassio Kampits Alex Nogueira Haas Cassiano Kuchenbecker Rosing Eneida Rejane Rabelo-Silva | 2015 | World Journal of Cardiology2015，7，1： | 9 |
| 2 | 抑制平滑肌的张力收缩:一种治疗勃起功能障碍的新途径显示文摘阴茎海绵体血管的收缩及张力的维持是由钙敏感的RhoA/Rho激酶信号传导途径介导的。以Y 2 76 32抑制海绵体平滑肌细胞的Rho激酶信号系统可促进阴茎勃起 ,表现为海绵体内压 (ICP)明显升高 ,而平均动脉压 (MAP)变化不显著。为什么在血管收缩信号很强的情况下性刺激仍能引发阴茎勃起反应 ?我们设想体内一氧化氮 (NO)能直接抑制RhoA/Rho激酶途径的活性 ,减少血管张力 ,促使血管舒张 ,勃起发生 ,使用Y 2 76 32可以恢复性腺功能低下和高血压病动物ED模型的阴茎勃起功能 ,这表明抑制Rho激酶活性药物具有临床应用的前景。此外 ,我们的结果显示阴茎表面使用Rho激酶抑制剂可能为ED治疗的有效方法之一。 | 戴玉田 Thomas M MILLS Ronald W LEWIS RClinton WEBB | 2002 | 中华男科学杂志2002，8，6： | 8 |
| 3 | Neurophysiological basis of penile erection显示文摘阴茎勃起包含在中央 nervoussystem 之间的一个复杂相互作用,本地 factors.It 是调制由的一个神经与血管的事件心理并且氮的氧化物的 hormonalfactors.The 发现(没有)作为为识别生理的位于下面的重要机制和 pathophysiological eventsin 的一个细胞间的送信人或 neurotransmitter pavedthe 方法阴茎,除了提供,为新治疗学的发展的知识基于分子和房间相互作用的 ona | Fernanda B M PRIVIERO Romulo LEITE R Clinton WEBB Cleber E TEIXEIRA | 2007 | Acta Pharmacologica Sinica2007，28，6： | 3 |
| 4 | Landscape features and weather influence nest survival of a ground-nesting bird of conservation concern,the greater sage-grouse,in humanaltered environments显示文摘Introduction:Ground-nesting birds experience high levels of nest predation.However,birds can make selection decisions related to nest site location and characteristics that may result in physical,visual,and olfactory impediments to predators.Methods:We studied daily survival rate[DSR]of greater sage-grouse(Centrocercus urophasianus)from 2008 to 2010 in an area in Wyoming experiencing large-scale alterations to the landscape.We used generalized linear mixed models to model fixed and random effects,and a correlation within nesting attempts,individual birds,and years.Results:Predation of the nest was the most common source of nest failure(84.7%)followed by direct predation of the female(13.6%).Generally,landscape variables at the nest site(≤30 m)were more influential on DSR of nests than features at larger spatial scales.Percentage of shrub canopy cover at the nest site(15-m scale)and distances to natural gas wells and mesic areas had a positive relationship with DSR of nests,whereas distance to roads had a negative relationship with DSR of nests.When added to the vegetation model,maximum wind speed on the day of nest failure and a 1-day lag in precipitation(i.e.,precipitation the day before failure)improved model fit whereby both variables negatively influenced DSR of nests.Conclusions:Nest site characteristics that reduce visibility(i.e.,shrub canopy cover)have the potential to reduce depredation,whereas anthropogenic(i.e.,distance to wells)and mesic landscape features appear to facilitate depredation.Last,predators may be more efficient at locating nests under certain weather conditions(i.e.,high winds and moisture). | Stephen L Webb Chad V Olson Matthew R Dzialak Seth M Harju Jeffrey B Winstead Dusty Lockman | 2012 | Ecological Processes2012，1，1： | 2 |
| 5 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 6 | Herpes simplex virus gE/gl sorts nascent virions to epithelial cell junctions, promoting virus spread显示文摘 | Johnson DC Webb M Wisner TW | 2001 | Virology2001，75，2： | 1 |
| 7 | Student learning with concept mapping of care plans in community-based education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 8 | Recent advances in stream and river temperature research显示文摘 | WEBB B W HANNAH D M MOORE R D | 2008 | Hydrological Processes2008，22，7： | 1 |
| 9 | Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion-preliminary report显示文摘 | Laron Z Ginsberg S Webb M | 2008 | Growth Horm IGF Res2008，18，5： | 1 |
| 10 | Prediction of radiative transfer in aluminum-recycling furnace 显示文摘 | SOLOVJOV V P WEBB B M | 2005 | Journal of the Institute of Energy2005，78，1： | 1 |
| 11 | The mutationally activated Met receptor mediate motility and metastasis显示文摘 | Jeffers M Fiscella M Webb CP1 | 1998 | Proc Natl Acad Sci U S A1998，95，14： | 1 |
| 12 | Skin care of the pediatric patient显示文摘 | Pallija G Mondozzi M Webb AA | 1999 | J Pediatr Nurs1999，14，2： | 1 |
| 13 | Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease显示文摘 | O'Donnell DE Lam M Webb KA | 1998 | Am J Respir Grit Care Med1998，158，51： | 1 |
| 14 | Recent advances in stream and river temperature research显示文摘 | Webb B W Hannah D M Moore R D | 2008 | Hydrological Processes2008，22，： | 1 |
| 15 | Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14显示文摘 | Board PG Webb GC Coggan M | | 0，，： | 1 |
| 16 | Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas 显示文摘 | Webb SM Rigla M Wagner A | 1999 | J Clin En- docrinol Metab1999，84，10： | 1 |
| 17 | A propective randomised comparison of the dynamic hip screw and the gamma locking nail 显示文摘 | Radford PJ Needoff M webb JK | 1993 | J Bone Joint Sury Br1993，75，5： | 1 |
| 18 | Constrained customization of non-coplanar beam orientations in radiotherapy of brain turnouts 显示文摘 | Rowbottom CG Oldham M Webb S | 1999 | Phys Med Biol1999，44，2： | 1 |
| 19 | Cell migration at a glance显示文摘 | Vicente-Manzanares M Webb D J Horwitz A R | 2005 | J Cell Sci2005，118，21： | 1 |
| 20 | Advanced heat exchange technology for thermoelectric cooling devices显示文摘 | GILLY M D | 1998 | Trans ASME1998，120，3： | 1 |
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