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| 1 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 4 | On the Dynamic Response of a Suspended Cable显示文摘 | H M Irvine J H Griffin | 1974 | Earthquake Engineering and Structural Dynamics1974，4，： | 2 |
| 5 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 6 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 7 | Cable Structures Cambridge显示文摘 | Irvine H M | 1981 | The MIT Press1981，，： | 2 |
| 8 | Developmental analysis of elongation factor-1 expression in transgenic tobacco显示文摘 | URSIN V M IRVINE J M HIATT W R SHEWMAKER C K | 1991 | Plant Cell1991，3，6： | 1 |
| 9 | Suppression of avian influenza transmission in genetically modified chickens 显示文摘 | LYALL J IRVINE R M SHERMAN A | 2011 | Science2011，331，6014： | 1 |
| 10 | Hydrogen fertilizer bacteria or fungi?显示文摘 | IRVINE P SMITH M DONG Z | 2004 | Acta Hofliculturae2004，631，： | 1 |
| 11 | Pokeweed antiviral protein inactivates pokeweed ribosomes implications for the antiviral mechanism显示文摘 | BONNESS M S READY M P IRVIN J D | 1994 | Plant J1994，5，2： | 1 |
| 12 | Postmortem and perimortem caesarean section: what are the indications? 显示文摘 | Whitten M Irvine LM | 2000 | J R Soc Med2000，93，： | 1 |
| 13 | Regional citrate anticoagulation in continuous venovenous hemodiafiltration显示文摘 | Irvin M Wu Dat NC | 2000 | Am J Kidney Dis2000，35，5： | 1 |
| 14 | lmmunolgical aspects of premure ovarian failure associated with idiopathic Addison' s disease显示文摘 | Chan M W Scarth L | 1968 | Lancet1968，2，： | 1 |
| 15 | Noncoding RNAs and gene silencing 显示文摘 | Zaratiegui M Irvine DV Martienssen RA | 2007 | Cell2007，128，4： | 1 |
| 16 | Targeting hedgehog in hematologic malignancy显示文摘 | Irvine DA Copland M | | Blood0，119，10： | 1 |
| 17 | Free vibrations of inclined cables显示文摘 | Irvine H M | 1978 | Journal of the Structural Division1978，104，2： | 1 |
| 18 | Overex-pression of tumor necrosis factor -c prodces an increase inlung volumes and pulmonary hypertension显示文摘 | Fujita M Shannon JM Irvin CG | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，1： | 1 |
| 19 | Fire hazards and some common polymers 显示文摘 | IRVINE D J MCCLUSKEY J A ROBINSON I M | 2000 | Polym Degrad Stab2000，67，3： | 1 |
| 20 | Inositol trisphosphate, a novel second messenger in cellular signal transductiou 显示文摘 | Berridge M J Irvine RF | 1984 | Nature1984，312，5992： | 1 |
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