|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 预测研究揭示肝硬化急性失代偿具有三个不同病理生理学特征的临床病程显示文摘【据Journal of Hepatology 2020年10月报道】题:预测研究揭示肝硬化急性失代偿具有三个不同病理生理学特征的临床病程(作者Trebicka J等)肝硬化急性失代偿(AD)是指代偿期肝硬化发展至出现腹水、消化道出血、肝性脑病、感染或前述并发症合并发生,需要住院治疗。如AD患者出现器官衰竭,则定义为慢加急性肝衰竭(ACLF)。 | TREBICKA J FERNANDEZ J PAPP M 高沿航 | 2020 | 临床肝胆病杂志2020，36，11： | 25 |
| 2 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 3 | Food groups, diet quality and colorectal cancer risk in the Basque Country显示文摘BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study populations.AIM To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as controls.During recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was collected.Adherence to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the MedDietScore.Conditional logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC risk.RESULTS The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC risk.While the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for CRC.Moreover,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern. | Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo Garcia-Etxebarria Ana MªRocandio Marta Arroyo-Izaga | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 4 | Electrodeposited and selenized (CuInSe2) (CIS) thin films for photovoltaic applications显示文摘 | Fernandez A M Calixto M E Sebastian P J | 1998 | Solar Energy Materials &Solar Cells1998，52，34： | 2 |
| 5 | Hepatic pseudolesion: appearance of focal low attenuation in the medial segment of the left lobe at CT arterial portography显示文摘 | del Fernandez M Pilar Bernardino M E | 1991 | Radiology1991，181，3： | 2 |
| 6 | Epidemiological link between obesity,type 2 diabetes mellitus and cancer显示文摘There exists a complex interaction between obesity,type 2 diabetes mellitus(T2DM)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic.The association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal cancer.Moreover,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors.In this review,we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and T2DM.Additionally,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis. | Cornelius J Fernandez Annu Susan George Nikhila A Subrahmanyan Joseph M Pappachan | 2021 | World Journal of Methodology2021，11，3： | 2 |
| 7 | Occurrence of Organochlorine Insecticides, PCBs and PCB Congeners in waters and Sediments of the Ebro River (Spain) 显示文摘 | Fernandez M A Alonso C Gonzalez M J | 1999 | Chemosphere1999，38，： | 2 |
| 8 | Cadmium inhibition of a structural wheat peroxidase显示文摘 | Converso D A Fernandez M E Tomaro M L | 2000 | J Enzy Inhib2000，15，： | 2 |
| 9 | Developing a Marker of exposure to xenoestrogen mixtures in human serum显示文摘 | Soto A M Fernandez M F Luizzi M F | 1997 | Environ Health Perspect1997，105，3： | 2 |
| 10 | Urinary cadmium levels during pregnancy and postpartum:a longitudinal study 显示文摘 | Hernandez M Schuhmacher M Fernandez JD | 1996 | Biol Trace Elem Res1996，53，： | 2 |
| 11 | Discrepancies in the clinical and radiological profiles of COVID-19:A case-based discussion and review of literature显示文摘The current gold standard for the diagnosis of coronavirus disease-19(COVID-19)is a positive reverse transcriptase polymerase chain reaction(RT-PCR)test,on the background of clinical suspicion.However,RT-PCR has its limitations;this includes issues of low sensitivity,sampling errors and appropriate timing of specimen collection.As pulmonary involvement is the most common manifestation of severe COVID-19,early and appropriate lung imaging is important to aid diagnosis.However,gross discrepancies can occur between the clinical and imaging findings in patients with COVID-19,which can mislead clinicians in their decision making.Although chest X-ray(CXR)has a low sensitivity for the diagnosis of COVID-19 associated lung disease,especially in the earlier stages,a positive CXR increases the pre-test probability of COVID-19.CXR scoring systems have shown to be useful,such as the COVID-19 opacification rating score which helps to predict the need of tracheal intubation.Furthermore,artificial intelligence-based algorithms have also shown promise in differentiating COVID-19 pneumonia on CXR from other lung diseases.Although costlier than CXR,unenhanced computed tomographic(CT)chest scans have a higher sensitivity,but lesser specificity compared to RT-PCR for the diagnosis of COVID-19 pneumonia.A semi-quantitative CT scoring system has been shown to predict short-term mortality.The routine use of CT pulmonary angiography as a first-line imaging modality in patients with suspected COVID-19 is not justifiable due to the risk of contrast nephropathy.Scoring systems similar to those pioneered in CXR and CT can be used to effectively plan and manage hospital resources such as ventilators.Lung ultrasound is useful in the assessment of critically ill COVID-19 patients in the hands of an experienced operator.Moreover,it is a convenient tool to monitor disease progression,as it is cheap,non-invasive,easily accessible and easy to sterilise.Newer lung imaging modalities such as magnetic resonance imaging(MRI)for safe imaging among children,adolescents and pregnant women are rapidly evolving.Imaging modalities are also essential for evaluating the extra-pulmonary manifestations of COVID-19:these include cranial imaging with CT or MRI;cardiac imaging with ultrasonography(US),CT and MRI;and abdominal imaging with US or CT.This review critically analyses the utility of each imaging modality to empower clinicians to use them appropriately in the management of patients with COVID-19 infection. | Hemant Kumar Cornelius James Fernandez Sangeetha Kolpattil Mohamed Munavvar Joseph M Pappachan | 2021 | World Journal of Radiology2021，13，4： | 2 |
| 12 | Study of the calcification of bovine pericardium: Analysis of the implication of lipids and proteogly cans显示文摘 | Herrero E J Fernandez P Gutierrez M | 1991 | Biomaterials1991，12，： | 1 |
| 13 | Postpartum hemolytic uremic syndrome:a rare entity and a treatment challenge 显示文摘 | Alsina Segui E Martin Conde M Craver Hospital L Fernandez Oiraldez E | 2008 | Nefrologia2008，28，： | 1 |
| 14 | Comparison of solid-phase microextraction and stir bar sorptive extraction for determining six organophosphorus insecticides in honey by liquid chromatography-mass spectrometry显示文摘 | BLASCO C FERNANDEZ M PICO Y | 2004 | Journal of Chromatography A2004，1030，12： | 1 |
| 15 | Incidence on power system dynamics of high penetration of fixed speed and doubly fed wind energy systems-study of the spanish case显示文摘 | Fernandez J L Beato D | 2002 | IEEE Transactions on Power Systems2002，17，4： | 1 |
| 16 | Bacterial infections in cirrhosis:epidemiological changes with invasive procedures and norfloxacin prophylaxis显示文摘 | Fernandez J Navasa M Gomez J | 2002 | Hepatology2002，35，1： | 1 |
| 17 | Determinants of innovation through a knowledge -based theory lens显示文摘 | Aranda D A Molina- Fernandez L M | 2002 | Industrial Management Data Systems2002，102，56： | 1 |
| 18 | Effect of chromium tripicolinate on growth, glucose tolerance, insulin sensitivity, plasma metabolites, and growth hormone in pigs 显示文摘 | AMOIKON E K FERNANDEZ J M SOUTHERN L L | 1995 | Journal of Animal Science1995，73，： | 1 |
| 19 | Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/pheno- type to thriftiness显示文摘 | Fernandez Real J M Ricart W | 1999 | Diabetologia1999，42，11： | 1 |
| 20 | Depressive symptoms in Parkinson disease correlate with impaired global and specific cognitive performance 显示文摘 | Fernandez H H See R H Gary M F | 2009 | J Geriatr Psychiatry Neurol2009，22，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员