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| 1 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 2 | Impaired CTLA-4 responses in COPD are associated with systemic inflammation显示文摘 | Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 3 | Electrodeposited and selenized (CuInSe2) (CIS) thin films for photovoltaic applications显示文摘 | Fernandez A M Calixto M E Sebastian P J | 1998 | Solar Energy Materials &Solar Cells1998，52，34： | 2 |
| 4 | Study of the calcification of bovine pericardium: Analysis of the implication of lipids and proteogly cans显示文摘 | Herrero E J Fernandez P Gutierrez M | 1991 | Biomaterials1991，12，： | 1 |
| 5 | Closed-loop adaptive optics in the human eye显示文摘 | FERNANDEZ E J IGLESIAS I ARTAL P | 2001 | Optics Letters2001，26，10： | 1 |
| 6 | Evaluation of tile effect of training using auditory stimulation on rhythmic movement in Parkinsonian patients - a combined motor and -FDG PET study 显示文摘 | Fernandez M Arias P Furio MC | 2006 | Parkinsonism Relat Disord2006，12，3： | 1 |
| 7 | Investigation on the role played by fermentation esters in the aroma of young Spanish wines by multivariate analysis显示文摘 | FERREIRA V FERNANDEZ P PENA C ct al | 1995 | J Sci Food Agr1995，67，3： | 1 |
| 8 | Apexification of a replanted tooth us- ingmineral trioxide aggregate 显示文摘 | Villa P Fernandez R | 2005 | Dent Tranmatol2005，21，5： | 1 |
| 9 | Cramer-Rao bound analysis of positioning approaches in the GNSS receivers显示文摘 | Closas P Fernandez-Prades C Fernandez'Rubio J A | 2009 | IEEE Transactions on Signal Pro- cessing2009，57，10： | 1 |
| 10 | Characterisation of an unbound granular mixture with waste tyre rubber for subballast layers显示文摘 | SIGNES C H FERNANDEZ P M PERALLON E M | 2015 | Materials and Structures2015，48，12： | 1 |
| 11 | Nonlinear I-V electrical behaviour of doped CaCu3Ti4O12 ceramics 显示文摘 | LERET P FERNANDEZ J F FRUROS J | 2007 | J Eur Ceram Soc2007，27，： | 1 |
| 12 | Availability of phosphorus in a Brazilian Oxisol cultivated with Eucalyptus after nine years as influenced by phosphorus-fertilizer source,rate and placement显示文摘 | DIAS L E FERNANDEZ J Q P BARROS N F | 2001 | Communications in soil science and plant analysis2001，32，78： | 1 |
| 13 | Proximal migration of a Double J catheter:case report and review of the literature显示文摘 | Garrido Abad P Fernandez Arjona M Fernández González I | 2008 | Arch Esp Urol2008，61，3： | 1 |
| 14 | Influence of ultra high pressure processing on fruit and vegetable products显示文摘 | Butz P Fernandez Garcia A Lindauer R | 2003 | Journal of Food Engineering2003，56，23： | 1 |
| 15 | Influence of high pressure processing on fruit and vegetable products显示文摘 | Butz P Fernandez G Lindauer R | 2003 | Journal of Food Engineering2003，，56： | 1 |
| 16 | Characterization of co-electrodeposited and selenized CIS (CuInSe2) thin films显示文摘 | Fernandez A M Sebastian P J Calixto M E | 1997 | Thin Solid Films1997，298，12： | 1 |
| 17 | Acute respiratory distress syndrome in trauma patients : ICU mortality and prediction factors 显示文摘 | Navarrete - Navarro P Ruiz -Bailen M Rinera Fernandez R | 2000 | Intensive Care Med2000，26，： | 1 |
| 18 | Struggling and flumazenil effects in the swimming test are related to the level of anxiety in mice显示文摘 | Ferre P Fernandez Teruel A Escorihuela RM | 1994 | Neuropsychobiology1994，29，1： | 1 |
| 19 | Eeto - 5' - nueleotidase ( CD73 ) - mediated extraeellular adenosine production plays a eritical role in hepatic fibrosis 显示文摘 | Peng Z Fernandez P Wilder | 2008 | FASEB J2008，8，： | 1 |
| 20 | PBDEs and PBBs in the adipose tissue of women from Spain 显示文摘 | FERNANDEZ M F ARAQUE P KIVIRANTA H | 2007 | Chemosphere2007，66，： | 1 |
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