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| 1 | 晚新生代岷江下蚀速率及其对青藏高原东缘山脉隆升机制和形成时限的定量约束显示文摘青藏高原东缘具有青藏高原地貌、龙门山高山地貌和山前冲积平原三个一级地貌单元 ,本文以岷江作为切入点 ,研究了该地区河流下蚀速率与山脉的隆升作用之间的相互关系。在建立岷江阶地序列的基础上 ,利用阶地高程和热释光年代学测年资料分别定量计算了岷江在川西高原、龙门山和成都盆地的下蚀速率 ,结果表明岷江各河段的下蚀速率明显不同 ,分别为 1.0 7~ 1.6 1mm / a、1.81m m/ a和 0 .5 9mm / a;在龙门山地区岷江的下蚀速率最高 ,约为川西高原地区的 1.5倍 ,约为成都平原地区的 3倍 ;而同一河段不同时期岷江的下蚀速率基本是连续的 ,具有很好的线性关系 ,可作为该河段整个河谷的下蚀速率。基于龙门山的表面隆升速率 (0 .3~ 0 .4 mm / a) ,在约束局部侵蚀基准面和气候变化对阶地形成的控制作用的基础上 ,本文建立了青藏高原东缘岷江下蚀速率与龙门山表面隆升速率之间的线性关系 ,结果表明河流下蚀速率约为山脉表面隆升速率的 5倍。根据龙门山表面在隆升速率和下切速率等方面均大于川西高原 ,并结合龙门山活动构造以走滑作用为主 ,笔者认为青藏高原东缘的边缘山脉以剥蚀隆升为主 ,兼有构造隆升作用。最后 ,根据岷江最大切割深度所需的时间 (3.4 8Ma)和成都盆地最古老的岷江冲积扇大邑砾岩的时间 (3.6 | 李勇 曹叔尤 周荣军 AL DENSMORE M A ELLIS | 2005 | 地质学报2005，79，1： | 70 |
| 2 | 青藏高原东缘龙门山晚新生代走滑挤压作用的沉积响应显示文摘成都盆地位于青藏高原东缘,夹于龙门山与龙泉山之间,盆地的长轴方向平行于龙门山,呈现为北东—南西向展布的线性盆地。盆地中充填了3.6Ma以来的半固结—松散堆积物,最大厚度为541m,在垂向上由下部的大邑砾岩、中部的雅安砾石层和上部的上更新统至全新统砾石层组成,其与下覆地层均为不整合接触,显示该盆地是一个单独的成盆期,并非是在中生代前陆盆地基础上形成的继承性盆地。在垂直于龙门山造山带方向上,成都盆地具不对称的楔形结构,沉积基底面整体向西呈阶梯状倾斜,盆地中充填的碎屑物质均来源于盆地西侧的龙门山,具横向水系和单向充填的特征;而且盆地的沉降中心具有逐渐向远离造山带方向迁移的特征,显示盆地的挤压方向垂直于龙门山主断裂,造成了成都盆地在垂直于造山带方向上的构造缩短。在平行于龙门山造山带方向上,成都盆地具有一系列的北东向延伸的次级凸起和凹陷,凹陷和凸起相间分布,且在空间上呈斜列形式展布于盆地的底部,其中次级凹陷(沉降中心)和冲积扇具有向平行龙门山造山带方向迁移的特征,表明成都盆地西缘的龙门山断裂具有右旋走滑的特征。鉴于以上特征,认为成都盆地是在龙门山造山带晚新生代走滑与逆冲的联合作用下形成的走滑挤压盆地。 | 李勇 周荣军 Densmore A L Ellis M A 黎兵 | 2006 | 沉积学报2006，24，2： | 65 |
| 3 | 青藏高原东缘晚新生代成都盆地物源分析与水系演化显示文摘成都盆地位于青藏高原东缘,夹于龙门山与龙泉山之间,盆地中充填了3.6M a以来的大邑砾岩、雅安砾石层和晚更新世—全新世砾石层,其物源均来源于盆地西侧的龙门山,具横向水系和单向充填的特征。本次以物源区分析作为切入点,以岷江和青衣江水系为重点,采用砾岩成分分析、砂岩岩屑成分分析、重矿物分析和砾石的地球化学分析等基本方法,开展青藏高原东缘晚新生代以来的古水系重建工作,研究结果表明,成都盆地主要有两个物源区,其中成都盆地北部的都江堰街子场、崇州白塔山、大邑白岩沟、大邑氮肥厂、彭州丁家湾、彭州葛仙山等剖面中的砾石层在碎屑成分、重矿物和花岗岩砾石的地球化学成分等方面相似,应为古岷江的产物,而其与现代岷江在砾岩成分和重矿物特征等方面的差异性则表明古岷江可能存在改道的现象;成都盆地南部的庙坡剖面和熊坡东剖面中的砾石层在碎屑成分、重矿物和花岗岩砾石的地球化学成分等方面相似,应为古青衣江的产物,但其流向却与现代青衣江的流向不同,表明熊坡背斜是在大邑砾岩沉积之后隆起的,它的隆起迫使古青衣江改道。 | 李勇 黎兵 Steffen D DensmoreAL RichardsonNJ 周荣军 Ellis M A 张毅 | 2006 | 沉积学报2006，24，3： | 38 |
| 4 | 龙门山断裂带走滑方向的反转及其沉积与地貌标志显示文摘根据龙门山前陆盆地西缘沉降中心、冲积扇侧向迁移、活动构造地貌和古地磁等标志及龙门山在中生代以来的走滑作用和走滑方向的标定研究,结果表明:龙门山断裂带具有走滑性质,走滑方向曾发生过反转,在反转之前以左行走滑作用为特征,在反转之后以右行走滑作用为特征。根据地层记录和古地磁证据,认为龙门山走滑方向反转的时间应介于43 M a^3.6 M a之间,即由中生代至早新生代时期的左行走滑作用反转为晚新生代时期的右行走滑作用。然对龙门山断裂带走滑方向反转的成因初步分析认为晚新生代龙门山右行走滑作用是印-亚碰撞后构造作用的产物,晚三叠世至早新生代左行走滑作用是青藏高原自晚三叠世以来大陆碰撞作用导致松潘-甘孜褶皱带北东-南西向缩短的产物。 | 李勇 周荣军 A L Densmore M A Ellis | 2006 | 矿物岩石2006，26，4： | 32 |
| 5 | 青藏高原东缘龙门山晚新生代剥蚀厚度与弹性挠曲模拟显示文摘龙门山是青藏高原东缘边界山脉,具有青藏高原地貌、龙门山高山地貌和山前冲积平原三个一级地貌单元。利用数字高程模式图像和裂变径迹年代测定方法研究和计算龙门山晚新生代剥蚀厚度与剥蚀速率,结果表明:3.6 Ma以来龙门山的剥蚀厚度介于1.91-2.16 km之间,剥蚀速率介于0.53-0.60 mm/a之间。在此基础上,开展了该地区岩石圈的弹性挠曲模拟,结果表明龙门山的隆升机制具有以构造缩短隆升和剥蚀卸载隆升相叠合的特点。3.6 Ma之前,龙门山的隆升与逆冲推覆构造负载有关,以构造缩短驱动的构造隆升为特色;3.6 Ma之后,龙门山的隆升与剥蚀卸载驱动的抬升有关,并以剥蚀卸载隆升为特色,进而提出了龙门山晚新生代以来的隆升机制以剥蚀成山作用为主的认识。 | 李勇 A L DENSMORE 周荣军 M A ELLIS | 2005 | 地质学报2005，79，5： | 21 |
| 6 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 7 | 全球数字平台劳动者就业研究显示文摘国际劳工组织于2015年和2017年开展了两次问卷调查,样本覆盖全球75个国家的3500名劳动者。这些劳动者在全球运作的5家大型微任务平台工作。基于问卷调查结果,本文阐述了劳动者的基本特点及其从事这类工作任务的动机,分析了微任务平台的工作条件,介绍了鼓励平台和平台用户遵守最低标准的做法与实践,并提出了改善数字就业平台工作条件的一系列原则。 | Janine Berg Marianne Furrer Ellie Harmon Uma Rani M Six Silberman 孟彤 | 2019 | 中国劳动2019，，4： | 3 |
| 8 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 9 | Penetration of solids and biological activity into slow sand filters显示文摘 | Ellis K V Aydin M E | 1995 | Water Research1995，29，： | 2 |
| 10 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 11 | Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution显示文摘AIM:To optimize a xeno-free cryopreservation protocol for primary human hepatocytes.METHODS:The demand for cryopreserved hepatocytes is increasing for both clinical and research purposes.Despite several hepatocyte cryopreservation protocols being available,improvements are urgently needed.We first compared controlled rate freezing to polystyrene box freezing and did not find any significant change between the groups.Using the polystyrene box freezing,we compared two xeno-free freezing solutions for freezing of primary human hepatocytes:a new medium(STEM-CELLBANKER,CB),which contains dimethylsulphoxide(DMSO) and anhydrous dextrose,both permeating and non-permeating cryoprotectants,and the frequently used DMSO-University of Wisconsin(DMSOUW) medium.The viability of the hepatocytes was assessed by the trypan blue exclusion method as well as a calcein-esterase based live-dead assay before and after cryopreservation.The function of the hepatocytes was evaluated before and after cryopreservation by assessing enzymatic activity of 6 major cytochrome P450 isoforms(CYPs):CYP1A2,CYP2C9,CYP2C19,CYP2D6,CYP3A4 and CYP3A7.RESULTS:The new cryoprotectant combination preserved hepatocyte viability significantly better than the standard DMSO-UW protocol(P < 0.01).There was no significant difference in viability estimation between both the trypan blue(TB) and the Live-Dead Assay methods.There was a correlation between viability of fresh hepatocytes and the difference in cell viability between CB and DMSO protocols(r 2 = 0.69) using the TB method.However,due to high within-group variability in the activities of the major CYPs,any statistical between-group differences were precluded.Cryopreservation of human hepatocytes using the cryoprotectant combination was a simple and xeno-free procedure yielding better hepatocyte viability.Thus,it may be a better alternative to the standard DMSO-UW protocol.Estimating CYP activities did not seem to be a relevant way to compare hepatocyte function between different groups due to high normal variability between different liver samples.CONCLUSION:The cryoprotectant combination may be a better alternative to the standard DMSO-UW protocol in primary human hepatocyte cryopreservation. | Mohammed Saliem Frida Holm Rosita Bergstrm Tengzelius Carl Jorns Lisa-Mari Nilsson Bo-Gran Ericzon Ewa Ellis Outi Hovatta | 2012 | World Journal of Hepatology2012，4，5： | 2 |
| 12 | SOX2,a persistent marker for multipotential neural stem cells derived from embryonic stem cells,the embryo or the adult显示文摘 | Ellis P Fagan B M Magness S T | | 0，，24： | 2 |
| 13 | Joining of aluminium based metal matrix composites显示文摘 | ElliS M B D | 1996 | International Materials Reviews1996，41，2： | 2 |
| 14 | Formation of micronuclei in erythrocytes of the fathead minnow (Pimcphales promelas) after acute treatment with mitomycin C or cyclophosphamide 显示文摘 | WINTER M J ELLIS L C HUTCHINSON T H | 2007 | Mut Res2007，629，2： | 1 |
| 15 | Effect of osmotic stress on yield and polyolcontent of dicarboximide sensitive and resistant strains of Neurospora crassa 显示文摘 | Ellis S W Grindle M | 1981 | Mycol Res1981，95，： | 1 |
| 16 | Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy显示文摘 | Riley SC Crossley JA Ritoe SC Horne A Shade M Ellis PM Aitken DA Groome NP | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 17 | Fuel cell systems efficient,flexible energy conversion for the 21st century显示文摘 | Von Spakovsky M R Nelson D J | 2001 | Proc IEEE2001，89，12： | 1 |
| 18 | Scmidwarf(sd-1),'green revolution'rice,contains a defective gibberellin 20-oxidase gene显示文摘 | Ellis M H Chandler P M | 2002 | PNAS2002，99，13： | 1 |
| 19 | Calibration of a calorimeter for thermal resisitance measurements of advanced insulation panels显示文摘 | Ellis M W Davis A H | 2000 | HVACR research2000，6，3： | 1 |
| 20 | 1-year survival in a randomized trial of facilitated reperfusion; results from the FINESSE (Facilitated Intervention With Enhanced Reperfusion Speed to Stop Events) trial显示文摘 | Ellis SG Tendera M de Belder MA | 2009 | J Am Coll Cardiol Intv2009，2，： | 1 |
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