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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Problem-based learning and larger student groups:mutually exclusive or compatible concepts-a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，8，35： | 1 |
| 3 | Problem-based-learning and larger student groups:mutually exclusive or compatible concepts a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，8，： | 1 |
| 4 | Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID 显示文摘 | Kasner SE Lymn M J Chimowitz MI | 2006 | Neurology2006，67，7： | 1 |
| 5 | Problem-based learning and larger student groups:mutually exclusive or compatible concepts-a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | Bmc Med Educ2008，8，1： | 1 |
| 6 | Differential expression of phospholipase C δ1 in Wistar Kyoto compared to spontaneously hypertensive rats显示文摘 | Hodson EAM Lymn JS | 1998 | Biochem Soci Trans1998，26，2： | 1 |
| 7 | Problem based learning and larger student groups:mutually exclusive or compatible concepts a pilot study显示文摘 | Kingsbury M P Lymn J S | 2008 | BMC Med Educ2008，，8： | 1 |
| 8 | Problem-based learning and larger student groups: mutually exclusive or compatible concepts-a pilot study显示文摘 | KINGSBURY M P LYMN J S | 2008 | BMC Med Educ2008，8，： | 1 |
| 9 | Problem-based learning and larger student groups:mutually exclusive or compatible concepts-a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，18，8： | 1 |
| 10 | Problem-based-learning and larger stud- ent groups: mutually exclusive or compatible concepts a pilot study显示文摘 | Kingsnury MP Lymn JS | 2008 | BMC Med Educ2008，8，： | 1 |
| 11 | Problem-based learning and larger student groups:mutually exclusive or compatible concepts-a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | Bmc Med Educ2008，188，1： | 1 |
| 12 | Problem-based learning and larger student groups:mutually exclusive or compatible concepts-a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | Bmc Med Educ2008，8，1： | 1 |
| 13 | Problem-based learning and lar- ger student groups : mutually exclusive or compatible concrpts-a pilot study 显示文摘 | Martyn P Kingsbury Joanne S Lymn | 2008 | BMC Medical Education2008，8，35： | 1 |
| 14 | Spectrum of disease in familial focal and segmental glomerulosclerosis显示文摘 | Conlon PJ Lymn K Winn MP | 1999 | Kidney Int1999，56，11： | 1 |
| 15 | Use and evaluation of a mentoringscheme to promote integration of non-medical prescribing in a clini-cal context显示文摘 | Bowskill D Meade 0 Lymn JS | 2014 | BMC Med Educ2014，25，14： | 1 |
| 16 | Effect of inhibition of tyrosine phosphatases on voltage-operated calcium channel currents in rabbit isolated ear artery cells显示文摘 | Wijetunge S Lymn JS Hughes AD | 1998 | Br J Pharmacol1998，124，2： | 1 |
| 17 | Problem-based learning and larger student groups: mutually exclusive or compatible concepts - a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，8，： | 1 |
| 18 | problem - based - learning and larger student groups : mutually exclusive or compatible concepts a pilot study显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，8，： | 1 |
| 19 | The herbal extract Iberogast? improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis显示文摘 | Tessa H. Wright Roger Yazbeck Kerry A. Lymn Eleanor J. Whitford Ker Y. Cheah Ross N. Butler Christine Feinle-Bisset Amelia N. Pilichiewicz Suzanne Mashtoub Gordon S. Howarth | 2009 | Cancer Biology & Therapy2009，，10： | 1 |
| 20 | Problem - based learing and larger studentgroups: mutually exclusive or compatible concepts to a pilot study 显示文摘 | Kingsbury MP Lymn JS | 2008 | BMC Med Educ2008，8，： | 1 |
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