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| 1 | Potential role of nutraceutical compounds in inflammatory bowel disease显示文摘Conventional therapies for inflammatory bowel diseases(IBD) involve combinations of pharmacologic agents such as aminosalicylates, azathioprine, and corticosteroids. Recently, the therapeutic scenario has been heavily increased by the introduction of agents including monoclonal antibodies targeted to specific proinflammatory cytokines, to adhesion molecules, and the induction of anti-inflammatory cytokines and T-cell activation. However, the use of these drugs is accompanied by a certain number of side effects, with some of them being quite severe, rising concerns about the safety profile. Furthermore, the cost of these emerging therapeutic strategies is significant, considering the increasing incidence and the chronic trend of IBD. Nutraceuticals is a broad term used to describe any product derived from food sources claiming extra health benefits beyond the intrinsic nutritional value found in foods. The beneficial effects of nutraceutical compounds in human health have been emerging in the last decades. Although few clinical trials have been performed in IBD patients, nutraceuticals, such as herbal products or vitamins, are generally accepted as safer alternative/supplementation to conventional therapy. In vitro and IBD-animal models studies have shown their involvement in several biological processes, including antioxidant defenses, cell proliferation, gene expression, which could account for a role in the maintenance of the mucosal barrier integrity, the control of the inflammatory pathways and the modulation of the immune response. These data suggest a wide spectrum of positive effects exerted by nutraceuticals, with a high potential for a therapeutic use in humans. In the present review, the beneficial effects of the most investigated nutraceutical compounds in the setting of human IBD are discussed. | Tiziana Larussaa Maria Imeneoa Francesco Luzza | 2017 | World Journal of Gastroenterology2017，23，14： | 5 |
| 2 | Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study显示文摘瞄准:评估兰伯氏贾第虫的流行(G。兰氏鞭毛虫属) 在有急躁的肠症候群(IBS ) 和消化不良并且到的病人的感染证实哪个是最精确的测试在这个背景诊断感染。方法:连续地由于 IBS 或消化不良的症状在 2002 年 1 月和 2003 年 12 月之间第一次出席了门诊病人肠胃病学诊所的 137 个病人被招募。所有病人经历了临床的评估,第一步的 haematology 和化学测试,为乳糜泻的血清学试金, lactose-H (2 ) 呼吸测试,腹的 ultrasonography,和 esophagogastroduodenoscopy。Helicobacter pylori 地位被评估。在有比 45 年旧的 IBS 的症状的病人,结肠镜检查也被执行。在所有病人,十二指肠的活体检视和凳子样品为 G 的 trophozoites 和包囊被检验。由几个方法的兰氏鞭毛虫属。结果:G。兰氏鞭毛虫属在 9 个病人被识别。下列诊断也被做:IBS (100/137, 73%) ,机能性消化不良(62/137, 45%) ,器官的消化不良(33/137, 24%) ,并且乳糖不耐(75/137, 55%) 。一个重要协会在贾第虫病和 H pylori 感染之间被发现(c2=6.632, OR=12.4, CI=1.5-68.1 ) 。没有症状,可靠地允许贾第虫病的识别。当十二指肠的活体检视的组织学的检查显示了低敏感时,在十二指肠的活体检视和凳子样品考试的寄生虫的直接搜索在所有情况中给了一致结果(例如, 22.2%) 。结论:在这个连续系列, G 的诊断。兰氏鞭毛虫属感染与 IBS 和消化不良说明了 6.5% 病人。如果凳子样品检查被执行,为贾第虫病的诊断的十二指肠的活体检视可能是不必要的。 | Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Lansoprazole-basedtriple therapy versus ranitidine bismuth citrate-based dual therapyin the eradication of Helicobacter pylori in patients with duodenalulcer:a multicenter,randomized,double-dummy study显示文摘 | LUZZA F GIGLIO A CILIBERTO E | 2001 | ClinTher2001，23，5： | 1 |
| 4 | Supraventricular tachycardia in infants: epidemiology and clinical management 显示文摘 | Calabr5 MP Cerrito M Luzza F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 5 | Hypertrophic cardiomyopathy with persistent ST segment elevation simulating acute myocardial infarction显示文摘 | Luzza F Carerj S Oreto G | | 0，，04： | 1 |
| 6 | Supraventricular tachycardia in infants: Epidemiology and clinical management 显示文摘 | Calabrb MP Cerrito M Luzza F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 7 | Helicobacter pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance显示文摘 | Tiziana Larussa Isabella Leone Evelina Suraci Maria Imeneo Francesco Luzza Muhammad Atif Zahoor | 2015 | Journal of Immunology Research2015，，： | 1 |
| 8 | Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa显示文摘 | Luzza F Parrello T Monteleone G | 2000 | J Immunol2000，165，9： | 1 |
| 9 | Pathophysiology of congestive heart failure显示文摘 | LUZZA F BRUNI F RIZZO F | 2002 | Minerva Cardioangiol2002，50，3： | 1 |
| 10 | Response of human intestinal lamina propria T lymphcytes to interleukin-12:additive effects of interleukin-15 and 7显示文摘 | Monteleone G Parrello T Luzza F | 1998 | Gut1998，43，： | 1 |
| 11 | Salivary -specific immunoglobulin G in the diagnosis of Helicobacter pylofi infection in dyspeptic patients 显示文摘 | Luzza F Maletta M Imeneo M | 1995 | Am J Gastroenterol1995，90，5： | 1 |
| 12 | Expression of proinflammatory and Thl but not Th2 cytokines is enhanced in gastric mucosa of Helicobacter pylori infected children显示文摘 | Luzza F Parrello T Sebkova L | 2001 | Dig Liver Dis2001，33，1： | 1 |
| 13 | Pathophysiology of congestive heart failure显示文摘 | Luzza F Bruni F Rizzo F | 2002 | Minerva Cardioangiol2002，50，3： | 1 |
| 14 | Supraventricular tachy?cardia in infants: epidemiology and clinical management显示文摘 | CALABRO MP CERRITO M LUZZA F | 2008 | Curr Pharm Des2008，14，8： | 1 |
| 15 | Hypertrophic cardiomyopathy with persistent ST segment elevation simulating acute myocardial infarction显示文摘 | Luzza F Carerj S Oreto G | 2004 | Heart2004，90，4： | 1 |
| 16 | Salivary Immunoglobulin G Assay to diagnose Helicobacter pylori infection in children显示文摘 | Luzza F Oderda G Maria M | 1997 | Journal of clinical microbiology1997，3358，： | 1 |
| 17 | Wide QRS complex tachycardia:an old and new problem显示文摘 | Oreto G Luzza F Satullo G | | 0，，09： | 1 |
| 18 | Pathophysiology of congestive heartfailure显示文摘 | Luzza F Bruni F Rizzo F | 2002 | Minerva Cardioangiol2002，50，3： | 1 |
| 19 | Up-regulation of IL-17 is as- sociated with bioactive IL-8 expression in Helicobacter pylori infected human gastric mucosa显示文摘 | Luzza F Parrello T Monteleone G | 2000 | J Immunol2000，165，9： | 1 |
| 20 | Tilt-induced pseudosyncope显示文摘 | Luzza F Pugliatti P di Rosa S | 2003 | Int J Clin Pratt2003，57，5： | 1 |
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