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| 1 | Effect of Huqian Wan on liver-Yin and kidney-Yin deficiency patterns in patients with knee osteoarthritis显示文摘OBJECTIVE: To observe the curative effect of Huqian Wan on liver and kidney-Yin deficiency knee osteoarthritis(KOA).METHODS: One hundred patients were randomly divided into a treatment(50 patients) and control group(50 patients). In the treatment group, patients orally took the Chinese medicine Huqian Wan. Control group patients orally took Votalin, 75 mg, once a day, for 8 weeks. The visual analog scale(VAS), Western Ontario and Mc Master University Osteoarthritis Index(WOMAC), and Medical Outcomes Study Short Form 36-Item Health Survey(SF36) were used to evaluate the curative effect before treatment and after 8 and 16 weeks of treatment.RESULTS: VAS and WOMAC scores significantly decreased and SF 36 scores significantly increased after treatment in both groups compared with before treatment(P < 0.05). There were significant differences in VAS, WOMAC, and SF 36 score changes between the two groups at week 16(P < 0.05).There was a significant increase in VAS and WOMAC scores in the control groups(P < 0.05) between weeks 8 and 16, but no significant difference was found in the treatment group(P > 0.05).CONCLUSION: Huqian Wan could effectively improve the clinical symptoms and quality of life in patients with KOA. It could also have a better and longer lasting curative effect without obvious adverse events compared with Votalin. | Chen Qiqing Jin Hongting He Bin Wang Liang Xiao Luwei Tong Peijian | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 8 |
| 2 | Copper as a single metal atom based photo-,electro-,and photoelectrochemical catalyst decorated on carbon nitride surface for efficient CO_(2) reduction:A review显示文摘The processes of photocatalytic CO_(2) reduction(pCO_(2)R)and electrochemical CO_(2) reduction(ECO_(2)R)have attracted considerable interest owing to their high potential to address many environmental and energy-related issues.In this aspect,a single Cu atom decorated on a carbon nitride(CN)surface(Cu-CN)has gained increasing popularity because of its unique advantages,such as excellent atom utilization and ultrahigh catalytic activity.CN-particularly graphitic CN(g-C_(3)N_(4))-is a photo-and electrocatalyst and used as an important support material for single Cu atom-based catalysts.These key functions of Cu-CN-based catalysts can improve the catalytic performance and stability in the pCO_(2)R and ECO_(2)R during the application process.In this review,we focus on Cu as a single metal atom decorated on CN for efficient photoelectrochemical CO_(2) reduction(pECO_(2)R),where ECO_(2)R increases the electrocatalytic active area and promotes electron transfer,while pCO_(2)R enhances the surface redox reaction by efficiently using photogenerated charges and offering integral activity as well as an active interface between Cu and CN.Interactions of single Cu atom-based photo-,electro-,and photoelectrochemical catalysts with g-C_(3)N_(4) are discussed.Moreover,for a deeper understanding of the history of the development of pCO_(2)R and ECO_(2)R,the basics of CO_(2) reduction,including pCO_(2)R and ECO_(2)R over g-C_(3)N_(4),as well as the structural composition,characterization,unique design,and mechanism of a single atom site are reviewed in detail.Finally,some future prospects and key challenges are discussed. | Lulu Li Israr Masood ul Hasan Farwa Ruinan He Luwei Peng Nengneng Xu Nabeel Khan Niazi Jia-Nan Zhang Jinli Qiao | 2022 | Nano Research Energy2022，1，2： | 7 |
| 3 | Changes and correlation of microorganism and flavor substances during persimmon vinegar fermentation显示文摘To investigate the microbial diversity and the change of the flavor substances during the traditional natural persimmon vinegar fermentation,two group samples from alcohol fermentation stage(A)and acetic acid fermentation stage(B)were analyzed.The results showed that Burkholderia,Lactobacillus,Acetobacter,Komagataeibacter were the main bacteria,and the major fungi were Saccharomyces,Hanseniaspora,Hortaea,and Cladosporium at the genus level.The contents of flavonoids and polyphenols in B increased by 17.91%and 26.59%compared with A,respectively.The superoxide anion scavenging activity significantly increased by 20.15%.The contents of total free amino acids were 5709.99±410.36 mg/L and 5736.16±472.02 mg/L,and the total contents of 9 organic acids were 19.89±1.20 g/L and 33.77±2.49 g/L in samples A and B,respectively.Pearson correlation analysis showed that 11 flavor compounds were related to Lactobacillus and Leuconostoc;8 and 10 compounds were respectively related to Komagataeibacter and Acetobacter;13 and 19 flavor compounds were respectively associated with Saccharomyces and Monascus.Orthogonal Partial Least Square(OPLS)model showed that the contents of Leu,Lys,and lactic acid were mainly associated with fungi,andγ-aminobutyric acid(GABA)content was correlated with Lactobacillus,Acetobacter,Leuconostoc,and Saccharomyces.This study revealed the relationship between microbial diversity and flavor compounds in persimmon vinegar produced by spontaneous fermentation.The results can provide a theoretical support for the safety and health assessment of persimmon vinegar. | Dahong Wang Mengyang Wang Luwei Cao Xiaotong Wang Jianrui Sun Jiangfeng Yuan Shaobin Gu | 2022 | Food Bioscience2022，46，2： | 4 |
| 4 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling显示文摘Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a hallmark of cancer.Targeting dysregulated metabolic features has become an important direction for modern anticancer therapy.In this study,we aimed to identify a new metabolic enzyme that promotes proliferation of CRC and to examine the related molecular mechanisms.Methods:We performed RNA sequencing and tissue microarray analyses of human CRC samples to identify new genes involved in CRC.Squalene epoxidase(SQLE)was identified to be highly upregulated in CRC patients.The regulatory function of SQLE in CRC progression and the therapeutic effect of SQLE inhibitors were determined by measuring CRC cell viability,colony and organoid formation,intracellular cholesterol concentration and xenograft tumor growth.Themolecularmechanism of SQLE functionwas explored by combining transcriptome and untargeted metabolomics analysis.Western blotting and realtime PCR were used to assess MAPK signaling activation by SQLE.Results:SQLE-related control of cholesterol biosynthesis was highly upregulated in CRC patients and associated with poor prognosis.SQLE promoted CRC growth in vitro and in vivo.Inhibition of SQLE reduced the levels of calcitriol(active form of vitamin D3)and CYP24A1,followed by an increase in intracellular Ca2+concentration.Subsequently,MAPK signaling was suppressed,resulting in the inhibition of CRC cell growth.Consistently,terbinafine,an SQLE inhibitor,suppressed CRC cell proliferation and organoid and xenograft tumor growth.Conclusions:Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling,highlighting SQLE as a potential therapeutic target for CRC treatment. | Luwei He Huaguang Li Chenyu Pan Yutong Hua Jiayin Peng Zhaocai Zhou Yun Zhao Moubin Lin | 2021 | Cancer Communications2021，41，8： | 4 |
| 5 | Performance analysis of a single-stage scroll compressor used in a drying heat pump over a wide condensing temperature range(30–80°C)显示文摘This study presents the performance of a new single-stage scroll compressor used for the heat pump drying of thermally sensitive materials over a wide temperature range.The performance of the new compressor was predicted by an ARI standard 540map-based compressor model and verified by a semi-open drying heat pump system constructed for this purpose.A comparison of the experimental data with the predicted data proved that the new scroll compressor used in the drying heat pump works well,can supply a wide range of condensing temperatures(30–80°C)(without auxiliary heating),and has a minimum coefficient of performance(COP)above 2.0,even in the worst condition. | WEI Juan YANG LuWei ZHANG ZhenTao LIN XueJun ZHANG Chong LI Bo | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 6 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China显示文摘Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor prognosis.Thus,global institutions have been working to develop mIDH2 inhibitors.SH1573 is a novel mIDH2 inhibitor that we independently designed and synthesised.We have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and safety.First,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal model.It could also promote the differentiation of mutant AML cell lines and granulocytes in PDX models.Then,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue distribution.Finally,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically safe.This research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe. | Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 3 |
| 7 | Assessment of biological changes in wheat seedlings induced by ^(12)C^(6+)-ion irradiation显示文摘The present study was designed to evaluate the effect of 12 6+ C ion beam (10~80 Gy) on biological changes of wheat seedlings. Reactive oxygen species (ROS)-related biomarkers and the quantification of plant survival and growth were examined at 10 day after carbon ions irradiation (LET: 30.8 keV/μm). The results showed that heavy ions obviously enhanced ROSs reflected by the production of O2 and H2O2 as well as TBARS, and - treatment with 20 Gy achieved the peak value, suggesting that higher mutagenic potential may occur at 20 Gy. Simultaneously, increase of SOD activity was induced by heavy ions to counteract ROS accumulation. On the other hand, higher doses at 40 and 80 Gy inhibited wheat growth and survival in comparison with the control, and reversely lower doses at 10 or 20 Gy stimulated wheat growth and survival. In conclusion, the above observations imply that a dose range of 20~40 Gy is likely promised for wheat mutation breeding. | ZHANG Luwei ZHANG Hong ZHANG Xiaofu ZHU Jianlan | 2008 | Nuclear Science and Techniques2008，19，3： | 2 |
| 8 | Shell powder as a novel bio-filler for thermal insulation coatings显示文摘The feasibility of employing shell powder as a novel bio-filler to prepare fluorocarbon coating is demonstrated.According to the relevant Chinese standards, the thermal and mechanical properties of the shell powder-filled fluorocarbon coating were evaluated, and compared with those filled by commercial calcium carbonate. All the shell powder-filled coatings can meet the requirements stated in the relevant standards, and with decreasing the particle size of the shell powders, the performance of the thermal insulation coating is enhanced. The coating(SC3) filled by shell powders with an average particle size of 2.81 μm possesses a better thermal insulation performance than the coating(CC) filled by commercial calcium carbonate. The coating SC3 has comparable adhesive force and washing resistance with the coating CC, and in the washing resistance test, after 2000 cycles, the coating SC3 was still able to cover totally their substrates. This work demonstrates a high value-added disposal method for the aquacultural wastes. | Peigen Zhang Jingwen Tang Qiang Tang Minzhao Zhang Luwei Shen Wubian Tian Yamei Zhang Zhengming Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 9 | Orthodontic simulation system with force feedback for training complete bracket placement procedures显示文摘Background A virtual system that simulates the complete process of orthodontic bracket placement can be used for pre-clinical skill training to help students gain confidence by performing the required tasks on a virtual patient.Methods The hardware for the virtual simulation system is built using two force feedback devices to support bi-manual force feedback operation.A 3D mouse is used to adjust the position of the virtual patient.A multi-threaded computational methodology is adopted to satisfy the requirements of the frame rate.The computation threads mainly consist of the haptic thread running at a frequency of>1000Hz and the graphic thread at>30Hz.The graphic thread allows the graphics engine to effectively display the visual effects of biofilm removal and acid erosion through texture mapping.Using the haptic thread,the physics engine adopts the hierarchy octree collision-detection algorithm to simulate the multi-point and multi-region interaction between the tools and the virtual environment.Its high efficiency guarantees that the time cost can be controlled within 1 ms.The physics engine also performs collision detection between the tools and particles,making it possible to simulate paint and removal of colloids.The surface-contact constraints are defined in the system;this ensures that the bracket will not divorce from or embed into the tooth during the adjustment of the bracket.Therefore,the simulated adjustment is more realistic and natural.Results A virtual system to simulate the complete process of orthodontic bracket bonding was developed.In addition to bracket bonding and adjustment,the system simulates the necessary auxiliary steps such as smearing,acid etching,and washing.Furthermore,the system supports personalized case training.Conclusions The system provides a new method for students to practice orthodontic skills. | Fan YE Luwei LIU Bin YAN Xiaohan ZHAO Aimin HAO | 2021 | Virtual Reality & Intelligent Hardware2021，3，4： | 2 |
| 10 | Two-Phase Critical Discharge of Initially Saturated or Subcooled Water Flowing in Sharp-Edged Tubes at High Pressure显示文摘Two-PhaseCriticalDischargeofInitiallySaturatedorSubcooledWaterFlowinginSharp-EdgedTubesatHighPressureXuJinliang(InstitueofNuc... | Jinliang Xu Tingkuan Chen Luwei Yang | 1995 | Journal of Thermal Science1995，4，3： | 2 |
| 11 | 埃塞俄比亚医疗卫生 挑战与机遇并存显示文摘埃塞俄比亚卫生体系面临的挑战
2011年,埃塞俄比亚人口总数为9100万人,而国内生产总值318亿美元,人均国民收入仅为387美元。尽管较前几年卫生总体情况有所好转,但该国相关卫生指标仍不容乐观。2010年,埃塞俄比亚人均寿命为54岁, | Luwei Pearson 季煦 Lucy Chen | 2013 | 中国卫生人才2013，，2： | 2 |
| 12 | Synthesis, adsorption and selectivity of inverse emulsion Cd(Ⅱ) imprinted polymers显示文摘Inverse emulsion polymerization was employed to synthesize inverse emulsion Cd(II) imprinted polymers(IEII P). The morphology and functional groups of IEIIP were characterized by SEM,FTIR and TG. Static adsorption experiments and competitive adsorption test were used to evaluate the adsorption ability of IEIIP. The adsorption capacity of polymers could reach 86.7 mg·g^(-1) under the optimal adsorption conditions. The pseudo second order kinetic model and Langmuir isotherm model could be used to analyze the experimental data well. The adsorption process of IEIIP was chemical adsorption process and monomolecular type. Thermodynamic parameters showed that the adsorption process was endothermic and could occur spontaneously. The selectivity coefficients k of Cd^(2+)/Pb^(2+), Cd^(2+)/Zn^(2+) and Cd^(2+)/Cu^(2+) were 2.4998, 1.2437 and 4.6882, respectively. The proposed method provides a new thought for removing Cd(II) in water samples. | Luwei Li Fang Zhu Yanhong Lu Jian Guan | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 2 |
| 13 | Carbon‐based metal‐free catalysts for electrochemical CO2 reduction: Activity, selectivity, and stability显示文摘Zero or negative emissions of carbon dioxide(CO2)is the need of the times,as inexorable rising and alarming levels of CO2 in the atmosphere lead to global warming and severe climate change.The electrochemical CO2 reduction(eCO2R)to value‐added fuels and chemicals by using renewable electricity provides a cleaner and more sustainable route with economic benefits,in which the key is to develop clean and economical electrocatalysts.Carbon‐based catalyst materials possess desirable properties such as high offset potential for H2 evolution and chemical stability at the negative applied potential.Although it is still challenging to achieve highly efficient carbon‐based catalysts,considerable efforts have been devoted to overcoming the low selectivity,activity,and stability.Here,we summarize and discuss the recent progress in carbon‐based metal‐free catalysts including carbon nanotubes,carbon nanofibers,carbon nanoribbons,graphene,carbon nitride,and diamonds with an emphasis on their activity,product selectivity,and stability.In addition,the key challenges and future potential approaches for efficient eCO2R to low carbon‐based fuels are highlighted.For a good understanding of the whole history of the development of eCO2R,the CO2 reduction reactions,principles,and techniques including the role of electrolytes,electrochemical cell design and evaluation,product selectivity,and structural composition are also discussed.The metal/metal oxides decorated with carbon‐based electrocatalysts are also summarized.We aim to provide insights for further development of carbon‐based metal‐free electrocatalysts for CO2 reduction from the perspective of both fundamental understanding and technological applications in the future. | Israr Masood ul Hasan Luwei Peng Jianfeng Mao Ruiman He Yongxia Wang Jing Fu Nengneng Xu Jinli Qiao | 2021 | Carbon Energy2021，3，1： | 2 |
| 14 | Thermal Performance Analysis of PCM Capsules Packed-Bed System with Biomimetic Leaf Hierarchical Porous Structure显示文摘As an efficient natural selection nutrient transport system,biomimetic leaf hierarchical porous structure has unique advantages in material transportation and energy transfer.Biomimetic leaf hierarchical porous structure has been widely used in solar thermochemical reactions,photocatalysis,and energy storage.To improve the thermal efficiency and reduce the power consumption,the authors introduce the idea of bionic leaf hierarchical porous structure packed-bed latent heat thermal energy storage(LHTES)system.Under the same porosity,the diameter of the PCM capsules is designed to change along the flow direction to optimize the thermal performance.The effects of velocity on temperature distribution,pressure drop,liquid fraction,and thermal storage capacity of the conventional uniform model and bionic leaf hierarchical porous model are analyzed.The results show that the bionic leaf hierarchical porous structure can thin the thickness of the thermocline,reduce the pressure drop,increase the heat transfer area,and improve the thermal response of the packed-bed compared with the conventional uniform model.The maximum increases of liquid fraction and completion rate are 36.6%and 20.3%with pressure drop reduction of 25 Pa,respectively.The maximum decrease of the above-melting point(MP)thermocline is 51.7%as well.These results provide suggestions to optimize the packed-bed LHTES system and improve its thermal performance under practical conditions. | DONG Yan WANG Fuqiang YANG Luwei SHI Xuhang ZHANG Guoliang SHUAI Yong | 2021 | Journal of Thermal Science2021，30，5： | 2 |
| 15 | Study on molecular interac-tion between NifA and NifL of Pseudomonas stutzeri A1501 by using the yeast two-hybrid system显示文摘 | XIEZhihong YANGYi PINGShuzheng CHENMing ZHANGwei LUWei XUYuquan LIUHongjuan WANGGuoying E.Claudine LINMin | 2005 | Chinese Science Bulletin2005，50，2： | 2 |
| 16 | Optimization of environmental maintenance system used in a refuge chamber显示文摘 | Junling Yang Luwei Yang Chong Zhang Zhentao Zhang Xiaojiang Li | 2015 | International Journal of Coal Science & Technology2015，2，4： | 2 |
| 17 | RRVPE:A Robust and Real-Time Visual-Inertial-GNSS Pose Estimator for Aerial Robot Navigation显示文摘Self-localization and orientation estimation are the essential capabilities for mobile robot navigation.In this article,a robust and real-time visual-inertial-GNSS(Global Navigation Satellite System)tightly coupled pose estimation(RRVPE)method for aerial robot navigation is presented.The aerial robot carries a front-facing stereo camera for self-localization and an RGB-D camera to generate 3D voxel map.Ulteriorly,a GNSS receiver is used to continuously provide pseudorange,Doppler frequency shift and universal time coordinated(UTC)pulse signals to the pose estimator.The proposed system leverages the Kanade Lucas algorithm to track Shi-Tomasi features in each video frame,and the local factor graph solution process is bounded in a circumscribed container,which can immensely abandon the computational complexity in nonlinear optimization procedure.The proposed robot pose estimator can achieve camera-rate(30 Hz)performance on the aerial robot companion computer.We thoroughly experimented the RRVPE system in both simulated and practical circumstances,and the results demonstrate dramatic advantages over the state-of-the-art robot pose estimators. | ZHANG Chi YANG Zhong XU Hao LIAO Luwei ZHU Tang LI Guotao YANG Xin ZHANG Qiuyan | 2023 | Wuhan University Journal of Natural Sciences2023，28，1： | 2 |
| 18 | Treatment of Chromite Ore Processing Residue by pyrolysis with rice straw显示文摘 | Dalei Zhang Shengbing He Luwei Dai Xiaofang Hu Deyi Wu Kangjin Peng Guanhuan Bu Hao Pang Hainan Kong | 2009 | Chemosphere2009，，8： | 1 |
| 19 | 显示文摘 | GUPei-fu CHENHai-xing LUWei etal(顾培夫 陈海星 陆巍 等) | 2004 | 光学学报2004，24，1： | 1 |
| 20 | cobalt catalysts显示文摘 | Luwei C Weng K Let aLHydrogen orsynthesis gas production via the partial oxidation ofmethane over supported nickel | 2007 | Int J Hydrogen Energy2007，32，6： | 1 |
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