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| 1 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 2 | Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease显示文摘AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease.METHODS Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/complications.RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population. | Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun | 2017 | World Journal of Gastroenterology2017，23，32： | 16 |
| 3 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 4 | Effects of captopril related to increased levels of prostacyclin and angiotensin-(1 - 7) in essential hypertension显示文摘 | LUQUE M MARTIN P MARTELL N | 1996 | J Hypertension1996，14，： | 1 |
| 5 | A feasibility study of the use of random amplified polymorphic DNA in the population genetics and systematics of grasshoppers显示文摘 | Chapco W Ashton NW Martel RK Antonishyn N Crosby WL | 1992 | Genome1992，35，4： | 1 |
| 6 | Triple negative breast cancer: current understanding of biology and treatment options 显示文摘 | KANG S P MARTEL M HARRIS L N | 2008 | Curt Opin Obstet Gynecol2008，20，1： | 1 |
| 7 | Effects of captopril related to increased levels of angiotensin-(1-7) in essential hypertension显示文摘 | Luque M Martin P Martell N | 1996 | Hypertension1996，14，： | 1 |
| 8 | Risk for heparin-indueed thromboeytopenia with unfraetionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis显示文摘 | Martel N Lee J Wells PS | 2005 | Blood2005，106，8： | 1 |
| 9 | PROMETHEE-MD-2T method for project selection显示文摘 | Halouani N Chabchoub H Martel J M | 2009 | European Journal of Operational Research2009，195，： | 1 |
| 10 | Gene amplicationat a locus encoding aputative Na+/H+antiporter conferssodium and lithium tolerance in fssion yeast显示文摘 | Jia Z P Mccullough N Martel R | 1992 | EMBOJ1992，11，： | 1 |
| 11 | Gaze characteristics of elite and near-elite athletes in ice hockey defensive tactics显示文摘 | Martell S G Vickers J N | 2004 | Human Movement Science2004，22，： | 1 |
| 12 | Behavioral activation for de- pression : returning to contextual roots 显示文摘 | Acobson N S Martell C R Dimidjian S | 2001 | Clinical psychology: sci- ence and practice2001，8，： | 1 |
| 13 | Risk for heparin-induced thrombocy-topenia with unfraetionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis 显示文摘 | Martel N Lee J Wells PS | 2005 | Blood2005，106，8： | 1 |
| 14 | Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular- weight heparin thromboprophylaxis: a meta-analysis 显示文摘 | Martel N Lee J Wells PS | 2005 | Blood2005，106，8： | 1 |
| 15 | Percutaneous radiofrequency ablation of benign bone tumors:osteoid osteoma,osteoblastoma,and chondroblastoma显示文摘 | Martel Villagrán J Bueno Horcajadas A Ortiz Cruz EJ | 2009 | Radiologia2009，51，6： | 1 |
| 16 | Characterization of Angiotensin(1-7) in the urine of normal and essential hypertensive subjects 显示文摘 | Ferrario CM Martell N Yunis C | 1998 | Am J Hypertens1998，11，2： | 1 |
| 17 | An application of a multicriteria approach to portfolio comparisons显示文摘 | Martel J M Khoury N T Bergeron M | 1988 | Journal of Operations Research Society1988，39，6： | 1 |
| 18 | Characterization of angiotensin(1~7)in the urine of normal and essential hypertensive subjects显示文摘 | Ferrario CM Martell N Yunis C | 1998 | Am J Hypertens1998，11，2： | 1 |
| 19 | Excess of metalloproteases over tissue inhibitor of metauoprottase may con - tribate to cartilage degradation in osteoarthritis in osteoarthritis and rheumatoid arthriti显示文摘 | Martel - pelletier J Mc Collum R Fujimoto N | 1994 | Lab Invest1994，70，： | 1 |
| 20 | Pdromethee-MD-2T method for project selection显示文摘 | Halouani N Chabchoub H Martel J M | 2009 | European Journal of Operational Research2009，195，3： | 1 |
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