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| 1 | Ribosome Biogenesis Factor Bmsl-like Is Essential for Liver Development in Zebrafish显示文摘Ribosome biogenesis in the nucleolus requires numerous nucleolar proteins and small non-coding RNAs.Among them is ribosome biogenesis factor Bmsl,which is highly conserved from yeast to human.In yeast,Bmsl initiates ribosome biogenesis through recruiting Rcll to pre-ribosomes.However,little is known about the biological function of Bmsl in vertebrates.Here we report that Bmsl plays an essential role in zebrafish liver development.We identified a zebrafish bms1l^(sq163) mutant which carries a T to A mutation in the gene bmsl-like(bms1l).This mutation results in L^(152) to Q^(152) substitution in a GTPase motif in Bmsll.Surprisingly,bmsll^(sq163) mutation confers hypoplasia specifically in the liver,exocrine pancreas and intestine after 3 days post-fertilization(dpf).Consistent with the bmsll^(sq163) mutant phenotypes,whole-mount in situ hybridization(WISH) on wild type embryos showed that bmsll transcripts are abundant in the entire digestive tract and its accessory organs.Immunostaining for phospho-Histone 3(P-H3) and TUNEL assay revealed that impairment of hepatoblast proliferation rather than cell apoptosis is one of the consequences of bms1l^(sq163) giving rise to an under-developed liver.Therefore,our findings demonstrate that Bmsll is necessary for zebrafish liver development. | Yong Wanga,Yue Luoa,Yunhan Hong(b,),Jinrong Peng(a,),Lijan Lo(a,b,) a College of Animal Sciences,Zhejiang University,Hangzhou 310058,China b Department of Biological Sciences,National University of Singapore,Science Drive 4,Singapore 117543,Singapore | 2012 | Journal of Genetics and Genomics2012，39，9： | 4 |
| 2 | Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells显示文摘MYC is a potent oncoprotein that modulates multiple cellular processes including proliferation,apoptosis, differentiation, stemness, senescence, and migration. Functioning primarily as a transcriptional factor, MYC interacts with a large number of proteins, and identification and characterization of MYC-interacting proteins are important for understanding how MYC functions. In this study, we used different systems to demonstrate that a novel zinc finger transcription factor, ZNF121, physically interacted with MYC, and the interaction involved their N-terminal regions. Overexpression of ZNF121 increased, while its knockdown decreased, the expression of MYC in multiple epithelial cell lines, and MYC had similar effects on ZNF121 expression. An expression correlation was also detectable in a panel of epithelial cell lines and a cohort of human breast cancer tissues. Functionally, knockdown of ZNF121 in several breast epithelial cell lines attenuated the expressions of MYC and its target genes(e.g., EGR1,CDC2, and nucleolin) and slowed cell proliferation, accompanied by cell cycle arrest in the G1 phase and expression alteration of cell cycle regulators(cyclin D1, p14 and p21). Analysis of publically available databases showed that ZNF121 expression is up-regulated in human breast cancer, and the up-regulation significantly associates with worse patient survival in the luminal A subtype of breast cancer. These findings establish ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation. | Ang Luoa Xuan Zhanga Liya Fua Zhengmao Zhua Jin-Tang Dong | 2016 | Journal of Genetics and Genomics2016，43，12： | 2 |
| 3 | Accuracy assessment of four cloud-free snow cover products over the Qinghai-Tibetan Plateau显示文摘Four up-to-date daily cloud-free snow products–IMS(InteractiveMultisensor Snow products),MOD-SSM/I(combination of the MODIS andSSM/I snow products),MOD-B(Blending method basing on the MODISsnow cover products)and TAI(Terra–Aqua–IMS)–with high-resolutionsover the Qinghai-Tibetan Plateau(QTP)were comprehensively assessed.Comparisons of the IMS,MOD-SSM/I,MOD-B and TAI cloud-free snowproducts against meteorological stations observations over 10 snowseasons(2004–2013)over the QTP indicated overall accuracies of 76.0%,89.3%,92.0%and 92.0%,respectively.The Khat values of the IMS,MODSSM/I,MOD-B and TAI products were 0.084,0.463,0.428 and 0.526,respectively.The TAI products appear to have the best cloud-removalability among the four snow products over the QTP.Based on theassessment,an I-TAI(Improvement of Terra–Aqua–IMS)snow productwas proposed,which can improve the accuracy to some extent.However,the algorithms of the MODIS series products show instabilitywhen identifying wet snow and snow under forest cover over the QTP.The snow misclassification is an important limitation of MODIS snowcover products and requires additional improvements. | Xiaohua Hao Siqiong Luoa Tao Che Jian Wang Hongyi Li Liyun Dai Xiaodong Huang Qisheng Feng | 2019 | International Journal of Digital Earth2019，12，4： | 2 |
| 4 | Use of Schmid factors to select extension twin variants in extruded magnesium alloy tubes 显示文摘 | Godet S JiangL LuoA A JonasJJ | 2006 | Scripta Materialia2006，55，11： | 1 |
| 5 | Calmodulin kinase Ⅱ and protein kinase c mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes显示文摘 | MaJ LuoA WuL | 2012 | Am J Physiol Cell Physiol2012，302，： | 1 |
| 6 | Inhibition of message for FceRI a chainblocks mast cell IL-4 production induced by coculture with Mycoplasma pneumoniae显示文摘 | Luoa D Daia Y Duffy LB | 2008 | Microbial Pathogenesis2008，44，2： | 1 |
| 7 | Statistical modeling and conceptualization of natural images显示文摘 | Jianping Fan Yuli Gaoa Hangzai Luoa | 2005 | Pattern Recognition2005，38，： | 1 |
| 8 | HPLC-ESI-MS analysis of Vitamin B12 in food products and in multivitamins-multimineral tablets显示文摘 | XUBIAO LUOA B CHENB BO DING LI | 2006 | Analytica Chimica Acta2006，，562： | 1 |
| 9 | Field induced spin transitions and large magneto-resistance in the quasi-one-dimensional magnet Ca3Co2O6显示文摘 | YAMADA K HONDA Z LUOA J | 2006 | J Alloy Compd2006，423，12： | 1 |
| 10 | Photo-induced Alignment Behavior of Azobenzene-containing Polymer Films with Different Cross-linking Degree显示文摘与各种各样的取代者和交叉连接的某些数量包含偶氮苯组的非结晶的共聚物的三个系列有能力的丙烯酸的组被准备。cross-linked 聚合物电影被丙烯酸的组的热聚合在共聚物,由控制 cross-linking 反应的时间,这些电影能与不同 cross-linking 度在期间被做获得(从 0 ~ 32% ,它被英尺红外系列测量监视) 。这些电影的导致相片的排列过程在 442 nm 与线性地极化的光在照耀下面被执行,并且导致相片的排列率上的 cross-linking 度的效果被调查。导致相片的排列的动力学与双性人一起被分析指数的曲线试穿。因为 cross-linking,导致相片的排列率和这些电影的最大的发射度减少了。为 cross-linked 样品,在重复了“写”并且“擦掉”周期以后,而且,他们发射度的浸透的价值保持不变,这被发现。调查结果表明电影罐头的 cross-linking 有效地由极化的光在照耀期间制止偶氮的聚合物的趋光性的集体运输。在 cross-linking 度和偶氮的聚合物的导致相片的排列行为之间的关系详细被讨论。 | Jing Shena Jin-tang Huang Yan-hua Luoa Qi-jin Zhang Ke-yi Wang | 2008 | Chinese Journal of Chemical Physics2008，21，5： | 1 |
| 11 | Application of ANN with extracted parameters from an electronic nose in cigarette brand identification显示文摘 | Luoa D Hosseini H G Stewart J R | 2004 | Sensors and Actuators B2004，99，： | 1 |
| 12 | Application of ANN with extracted parameters from an electronic nose in cigarette brand identification显示文摘 | Luoa D Hosseini H G Stewart J R | 2004 | Sensors and Actuators B2004，99，： | 1 |
| 13 | A fixed clustering protocol based on random relay strategy for EHWSN显示文摘In Energy Harvesting Wireless Sensor Networks(EHWSN),the communication protocol will directly affect the final performance of the network,so it is necessary to study the communication protocol based on EHWSN.In this paper,for the low-cost fixed clustering problem,a fixed clustering protocol RRCEH is based on random relaying.Our proposed RRCEH abandons the inefficient inter-cluster communication method of the traditional fixed clustering protocol.To coordinate the data upload of the cluster head,RRCEH allocates different random relay vectors to each ring area of the network,and combines all the random relay vectors into a random relay matrix of RRCEH.In each communication round,the cluster head node randomly selects its relay target node to send data according to the probability distribution in the random relay vector in the area.For two different cluster head configuration scenarios,by optimizing the random relay matrix,RRCEH can effectively reduce the network's configuration requirements for cluster head energy harvesting capability,thus reducing the deployment cost of EHWSN. | Xianquan Luoa Chunjiong Zhang Longju Bai | 2023 | Digital Communications and Networks2023，9，1： | 1 |
| 14 | MicroRNA-10bpromotesmigrationandinvasionthroughKLF4inhumanesophagealcancercelllines显示文摘 | TianY LuoA CaiY etal | 2010 | Thejournalofbiologicalchemistry2010，285，： | 1 |
| 15 | Liquid phase hydrogenation of furfural to furfuryl alcohol over the Fe-promoted Ni-B amorphous alloy catalysts显示文摘 | Hexing Li Hongshan Luoa Li Zhuang | 2003 | Journal of Molecular Catalysis A2003，203，： | 1 |
| 16 | High-speed ESPI and related techniques : overview and its application in the automotive industry显示文摘 | Chen F Luoa W D Daleb M | 2003 | Optics and Lasers in Engineering2003，40，： | 1 |
| 17 | Sequence analysis of six enterovirus 71 strains with different virulences in humans 显示文摘 | Guo -hui Chang Lei Lina Yan-jun Luoa | 2010 | Virus Research2010，151，1： | 1 |
| 18 | Design of double freeform - surface lens for LED uniform illumination with min- imum Fresnel losses 显示文摘 | Run Hua Zhiqiang Gane Xiaobing Luoa | 2013 | Optik2013，，124： | 1 |
| 19 | Global Salient Information Maximization for Saliency De- tection 显示文摘 | LUOA Wang LIA Hongliang LIUA Guanghui | 2012 | Signal Processing: Image Communication2012，27，： | 1 |
| 20 | High-speed ESPI and related techniques:overview and its application in the automotive industry显示文摘 | Chen F Luoa WD Daleb M | 2003 | Optics and Lasers in Engineering2003，40，： | 1 |
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