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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 3 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 4 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 5 | Distribution of ground - dwelling beetle assemblages (Coleoptera) across ecotones between Natural Oak Forests and Mature Pine Plantations in North China 显示文摘 | XD Luo TH Zhou HZ | 2010 | Journal of Insect Conservation2010，14，6： | 1 |
| 6 | Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study 显示文摘 | Shiao TH Liu C J Luo JC | 2013 | American Journal of Medicine2013，126，3： | 1 |
| 7 | The effect of perineural invasion on overall survival in patients with gastric carcinoma显示文摘 | Luo TH Fang GE Bi JW | | 0，，07： | 1 |
| 8 | Microarray analysis of gene expression in MEN1 knockout embryoid body reveals genetic events involved in early mouse embryonic development 显示文摘 | Zhang HL Luo TH Feng L | 2007 | Biochem Biophys Res Commun2007，352，2： | 1 |
| 9 | The Visfatin gene is associated with glucose and lipid metabolism in a Chinese population显示文摘 | Jian WX Luo TH Gu YY | 2006 | Diabet Med2006，23，9： | 1 |
| 10 | Salubrinal protects against cigarette smoke extract-induced HBEpC apoptosis likely via regulating the activity of PERK-eIF2α signaling pathway显示文摘 | Yuan T Luo BL Wei TH | | 0，，： | 1 |
| 11 | Zunyi County,climate change and its impact on agricultural production显示文摘 | Luo TH 2001 | 2001 | Guizhou Weather2001，1，25： | 1 |
| 12 | The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes 显示文摘 | Luo TH Wang Y Lu ZM | 2009 | Critical Care2009，13，4： | 1 |
| 13 | A genome-wide search for Type II diabetes susceptible genes in Chinese Hans显示文摘 | Luo TH Zhao Y Li G | 2001 | Diabetologia2001，44，4： | 1 |
| 14 | A genome-wide search for type Ⅱ diabetes susceptibility genes in Chinese Hans显示文摘 | Zhao Y Li G | 2001 | Diabetologia2001，44，4： | 1 |
| 15 | Optimization of culture condi-tions for endothelial progenitor cells from porcine bone marrow in vitro显示文摘 | Wu JG Luo TH Zhou H | 2010 | Cell Prolif2010，43，4： | 1 |
| 16 | The visfatin gene is associated with glucose and lipid metabolism in a Chinese population显示文摘 | Jian WX Luo TH Gu YY | 2006 | Diabetic Med2006，23，9： | 1 |
| 17 | Sleep apnea and risk of peptic ulcerbleeding:a nationwide population-based study 显示文摘 | Shiao TH Liu CJ Luo JC | 2013 | Am J Med2013，126，55： | 1 |
| 18 | Salubrinal protects against cigarette smoke extract-induced HBEpC apoptosis likely via regulating the activity of PERK-eIF2α signaling pathway显示文摘 | Yuan T Luo BL Wei TH | | 0，，： | 1 |
| 19 | The change and effect of endo-thelial progenitor cells in pig with multiple organ dysfunction syn-dromes显示文摘 | Luo TH Wang Y Lu ZM | 2009 | Crit Care2009，13，4： | 1 |
| 20 | Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells显示文摘 | Chou TH Park KK Luo X | 2013 | Invest Ophthalmol Vis Sci2013，54，2： | 1 |
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