4篇
您的检索式：作者名="Luling Xia"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Food phenolics, pros and cons: a review显示文摘 | Lule SU Xia W | 2005 | Food Rev Inter2005，21，5： | 1 |
| 2 | Food phenolics,pros and cons:a review显示文摘 | LULE S U XIA W | 2005 | Food Reviews International2005，21，4： | 1 |
| 3 | Food phenolics, pros and cons: a review 显示文摘 | Lule SU Xia W | 2005 | Food Reviews Inte rluaiotud2005，21，4： | 1 |
| 4 | Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma显示文摘Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of cancer.However,conventional cell-SELEX technologies for aptamer discovery are time-consuming and laborious.Here we discovered a new aptamer BC-3 by using an improved rapid X-Aptamer selection process for human bladder carcinoma,for which there is no specific molecular probe yet.We show that BC-3 exhibited excellent affinity in bladder cancer cells but not normal cells.We demonstrate that BC-3 displayed high selectivity for tumor cells over their normal counterparts in vitro,in mice,and in patient tumor tissue specimens.Further endocytosis pathway analysis revealed that BC-3 internalized into bladder cancer cells via clathrin-mediated endocytosis.Importantly,we identified ribosomal protein S7(RPS7)as the binding target of BC-3 via an integrated methodology(mass spectrometry,colocalization assay,and immunoblotting).Together,we report that a novel aptamer BC-3 is discovered for bladder cancer and its properties in the disease are unearthed.Our findings will facilitate the discovery of novel diagnostic and therapeutic strategies for bladder cancer. | Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu Yi Xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu | 2023 | Genes & Diseases2023，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员