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| 1 | A hydrophilic poly(methyl vinyl ether-alt-maleic acid) polymer as a green, universal, and dual-functional binder for high-performance silicon anode and sulfur cathode显示文摘Binders could play crucial or even decisive roles in the fabrication of low-cost, stable and high-capacity electrodes. This is especially the case for the silicon (Si) anodes and sulfur (S) cathodes that undergo large volume change and active material loss in lithium-ion batteries during prolonged cycles. Herein, a hydrophilic polymer poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was explored as a dual-functional aqueous binder for the preparation of high-performance silicon anode and sulfur cathode. Benefiting from the dual functions of PMVEMA, i.e., the excellent dispersion ability and strong binding forces, the as-prepared electrodes exhibit improved capacity, rate capability and long-term cycling performance. In particular, the as-prepared Si electrode delivers a high initial discharge capacity of 1346.5 mAh g^(−1) at a high rate of 8.4 A/g and maintains 834.5 mAh g^(−1) after 300 cycles at 4.2 A/g, while the as-prepared S cathode exhibits enhanced cycling performance with high remaining discharge capacities of 663.4 mAh g^(−1) after 100 cycles at 0.2 C and 487.07 mAh g^(−1) after 300 cycles at 1 C, respectively. These encouraging results suggest that PMVEMA could be a universal binder to facilitate the green manufacture of both anode and cathode for high-capacity energy storage systems. | Hao Chen Zhenzhen Wu Zhong Su Luke Hencz Su Chen Cheng Yan Shanqing Zhang | 2021 | Journal of Energy Chemistry2021，30，11： | 5 |
| 2 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 3 | Preparation and Characterization of MWCNTs/E44显示文摘环氧树脂被多围的碳 nanotubes (MWCNT ) 修改与一在原处方法。合成用扫描电子显微镜学(SEM ) 被观察, X-raydiffraction (XRD ) ,和它的磨料穿抵抗,张力的性质被测试。基于 MWCNT 的表面的功能组帮助改进树脂的裂缝抵抗的结果表演,和裂缝被发现显著地减少了在合成。尽管树脂 andMWCNTs 身体上被结合,张力的性质并且穿抵抗合成当 MWCNT 的最佳数量被填时,显著地被改进 Epikote-44 (E44 ) 。当 5 wt % 酸化时, MWCNT 被填 E44,有弹性的模量,断裂强度并且穿合成增加的抵抗到 226.7% , 303.3% 和 272.55%(153.29%) 分别地。 | Yan GAO Zhenjia WANG Rui WANG Ji LIANG Luke WANG | 2006 | Journal of Materials Science & Technology2006，22，1： | 1 |
| 4 | 20S-Protopanaxadiol Inhibits P-Glycoprotein in Multidrug Resistant Cancer Cells显示文摘 | Yan Zhao Luke Bu Hang Yan William Jia | 2009 | Planta Med2009，，10： | 1 |
| 5 | Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy显示文摘Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer patients.However,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic disease.Recent insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy resistance.Specialized immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune homeostasis.Despite the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy resistance.To improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer immunotherapy.Improved knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer. | Laura A.Huppert Michael D.Green Luke Kim Christine Chow Yan Leyfman Adil I.Daud James C.Lee | 2022 | Cellular & Molecular Immunology2022，19，1： | 1 |
| 6 | 50 W CW visible laser source at 589 nm obtained via frequency doubling of three coherently combined narrow-band Raman fiber amplifiers显示文摘 | Luke R T Yan Feng Domenico B C | 2010 | Opt Express2010，18，8： | 1 |
| 7 | Application of a new modified epoxy adhesive for bonding fuorine rubber to metal显示文摘 | Yan Luke Kou Kaichang Ji Tiezher~g | 2007 | Journal of Adhesion Science & Technology2007，21，15： | 1 |
| 8 | 结核分枝杆菌PknI激酶通过胞外传感器结构域二聚化被激活的结构研究显示文摘文章简介蛋白激酶对于宿主内结核分枝杆菌的存活起中心作用。课题组解析了丝氨酸/苏氨酸蛋白激酶(STPKs)家族里的跨膜蛋白成员Pkn I的传感器域(单体和二聚体形式)以及激酶域的高分辨率晶体结构。 | Qiaoling Yan Dunquan Jiang Lanfang Qian Qingqing Zhang Wei Zhang Weihong Zhou Kaixia Mi Luke Guddat Haitao Yang 饶子和 | 2018 | 科学新闻2018，0，4： | 0 |
| 9 | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB显示文摘The adenosine 5'-triphosphate(ATP)-binding cassette(ABC)transporter,IrtAB,plays a vital role in the replication and viability of Mycobacterium tuberculosis(Mtb),where its function is to import iron-loaded siderophores.Unusually,it adopts the canonical type IV exporter fold.Herein,we report the structure of unliganded Mtb IrtAB and its structure in complex with ATP,ADP,or ATP analogue(AMP-PNP)at resolutions ranging from 2.8 to 3.5Å.The structure of IrtAB bound ATP-Mg2+shows a“head-to-tail”dimer of nucleotide-binding domains(NBDs),a closed amphipathic cavity within the transmembrane domains(TMDs),and a metal ion liganded to three histidine residues of IrtA in the cavity.Cryo-electron microscopy(Cryo-EM)structures and ATP hydrolysis assays show that the NBD of IrtA has a higher affinity for nucleotides and increased ATPase activity compared with IrtB.Moreover,the metal ion located in the TM region of IrtA is critical for the stabilization of the conformation of IrtAB during the transport cycle.This study provides a structural basis to explain the ATP-driven conformational changes that occur in IrtAB. | Shan Sun Yan Gao Xiaolin Yang Xiuna Yang Tianyu Hu Jingxi Liang Zhiqi Xiong Yuting Ran Pengxuan Ren Fang Bai Luke WGuddat Haitao Yang Zihe Rao Bing Zhang | 2023 | Protein & Cell2023，14，6： | 0 |
| 10 | Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2显示文摘Inhibition of Mycobacterium tuberculosis(Mtb)cell wall assembly is an established strategy for anti-TB chemotherapy.Arabinosyltransferase EmbB,which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose(DPA)to its arabinosyl acceptor is an essential enzyme for Mtb cell wall synthesis.Analysis of drug resistance mutations suggests that EmbB is the main target of the front-line anti-TB drug,ethambutol.Herein,we report the cryo-EM structures of Mycobacterium smegmatis EmbB in its'resting state'and DPA-bound'active state'.EmbB is a fifteen-transmembrane-spanning protein,assembled as a dimer.Each protomer has an associated acyl-carrier-protein(AcpM)on their cytoplasmic surface.Confor-mational changes upon DPA binding indicate an asym-metric movement within the EmbB dimer during catalysis.Functional studies have identified critical residues in substrate recognition and catalysis,and demonstrated that ethambutol inhibits transferase activity of EmbB by competing with DPA.The structures represent the first step directed towards a rational approach for anti-TB drug discovery. | Lu Zhang Yao Zha Ruogu Gao Jun Li Xiuna Yang Yan Gao Wei Zhao Sudagar S.Gurcha Natacha Veerapen Sarah M.Batt Kajelle Kaur Besra Wenqing Xu Lijun Bi Xian'en Zhang Luke W.Guddat Haitao Yang Quan Wang Gurdyal S.Besra Zihe Rao | 2020 | Protein & Cell2020，11，7： | 0 |
| 11 | Molecular cytogenetic map visualizes the heterozygotic genome and identifies translocation chromosomes in Citrus sinensis显示文摘Citrus sinensis is the most cultivated and economically valuable Citrus species in the world,whose genome has been assembled by three generation sequencings.However,chromosome recognition remains a problem due to the small size of chromosomes,and difficulty in differentiating between pseudo and real chromosomes because of a highly heterozygous genome.Here,we employ fluorescence in situ hybridization(FISH)with 9 chromosome painting probes,30 oligo pools,and 8 repetitive sequences to visualize 18 chromosomes.Then,we develop an approach to identify each chromosome in one cell through single experiment of oligo-FISH and Chromoycin A3(CMA)staining.By this approach,we construct a high-resolution molecular cytogenetic map containing the physical positions of CMA banding and 38 sequences of FISH including centromere regions,which enables us to visualize significant differences between homologous chromosomes.Based on the map,we locate several highly repetitive sequences on chromosomes and estimate sizes and copy numbers of each site.In particular,we discover the translocation regions of chromosomes 4 and 9 in C.sinensis“Valencia.”The high-resolution molecular cytogenetic map will help improve understanding of sweet orange genome assembly and also provide a fundamental reference for investigating chromosome evolution and chromosome engineering for genetic improvement in Citrus. | Shipeng Song Hui Liu Luke Miao Li He Wenzhao Xie Hong Lan Changxiu Yu Wenkai Yan Yufeng Wu Xiao-peng Wen Qiang Xu Xiuxin Deng Chunli Chen | 2023 | Journal of Genetics and Genomics2023，50，6： | 0 |
| 12 | An advanced 2D/3D g-C_(3)N_(4)/TiO_(2)@MnO_(2) multifunctional membrane for sunlight-driven sustainable water purification显示文摘Graphitic carbon nitride(g-C_(3)N_(4))nanosheets have attracted widespread interest in the construction of advanced separation membranes.However,dense stacking and a single functionality have limited the membrane development.Here,an advanced two-/three-dimensional(2D/3D)g-C_(3)N_(4)/TiO_(2)@MnO_(2) membrane is constructed by intercalating 3D TiO_(2)@MnO_(2) nanostructures into g-C_(3)N_(4) nanosheets.The 3D flower-like nanostructures broaden the transport channels of the composite membrane.The membrane can effectively separate five oil-in-water(O/W)emulsions,with a maximum flux of 3265.67±15.01 L·m^(-2)·h^(-1)·bar^(-1) and a maximum efficiency of 99.69%±0.45%for toluene-in-water emulsion(T/W).Meanwhile,the TiO_(2)@MnO_(2) acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes(e^(-)–h^(+)).The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap(2.10 eV).These photoelectric properties give the membrane good degradation of three different pollutants,with about 100%degradation for methylene blue(MB)and malachite green(MG).The photocatalytic antibacterial efficiency of the membrane is also about 100%.After cyclic experiment,the membrane maintains its original separation and photocatalytic capabilities.The remarkable multifunctional and self-cleaning properties of the g-C_(3)N_(4) based membrane represent its potential value for complex wastewater treatment. | Fan Yu Chunjia Luo Xiaohan Niu Min Chao Pengfei Zhang Luke Yan | 2024 | Nano Research2024，17，4： | 0 |
| 13 | Cryo-EM structures of a prokaryotic heme transporter CvdDC显示文摘DearEditor,Heme is an essential cofactor required across all kingdoms of life utilized in numerous biological processes,including cellular respiration.CydDC is a prokaryotic ATP-binding cassette(ABC)transporter required for heme assembling in respiratory cytochrome bd oxidase(Georgiou et al.,1987;Poole et al.,1989),a promising target for drug discovery(Borisov et al.,2011).CydDC is thought to play a role in maintaining an optimum periplasmic redox poise that is required for the incorporation of heme cofactors(Yamashita et al.,2014).It also suggested that CydDC is involved in heme processing by mediating glutathione/cysteine translocation(Cook and Poole,2000;Cook et al.,2002),although a role in heme translocation seems unlikely(Yamashita et al.,2014).To date,CydDC has been shown to be important for disulfide bond formation,motility,respiration,and tolerance to nitric oxide and antibiotics(Poole et al.,2019). | Chen Zhu Yanfeng Shi Jing Yu Wenhao Zhao Lingqiao Li Jingxi Liang Xiaolin Yang Bing Zhang Yao Zhao Yan Gao Xiaobo Chen Xiuna Yang Lu Zhang Luke W.Guddat Lei Liu Haitao Yang Zihe Rao Jun Li | 2023 | Protein & Cell2023，14，12： | 0 |
| 14 | 沃尔巴克氏菌(Wolbachia)结合放射线的应用现场清除白纹伊蚊种群显示文摘《自然》杂志近期发表论文介绍中国、美国、国际原子能机构和澳大利亚科学家通过合作于2014—2017年在中国广东省广州市南沙区和番禺区2个江中沙洲岛屿,开展清除白纹伊蚊即登革病毒主要传播蚊虫的现场研究。该研究结合昆虫绝育技术(sterile insect technique,SIT),通过释放携带沃尔巴克氏菌(Wolbachia)的白纹伊蚊雄蚊,而达到靶向消灭现场野生白纹伊蚊的目的。研究结果显示,此项技术可年平均消灭现场白纹伊蚊83%~94%雌性成蚊和94%蚊卵,在部分区域实现了野生白纹伊蚊种群的灭绝。 | Xiaoying Zheng Dongjing Zhang Yongjun Li Cui Yang Yu Wu Xiao Liang Yongkang Liang Xiaoling Pan Linchao Hu Qiang Sun Xiaohua Wang Yingyang Wei Jian Zhu Wei Qian Ziqiang Yan Andrew GParker jeremie r.l.Gilles Kostas Bourtzis Jeremy Bouyer Moxun tang Bo Zheng Jianshe Yu Julian Liu Jiajia Zhuang Zhigang Hu Meichun Zhang Juntao Gong Xiaoyue Hong Zhoubing Zhang Lifeng Lin Qiyong Liu Zhiyong Hu Zhongdao Wu Luke Anthony Baton Ary AHoffmann Zhiyong Xi 毛伟(编译) 曾琴(编译) 潘晓玲(编译) 梁国栋(审校) | 2019 | 中华实验和临床病毒学杂志2019，33，5： | 0 |
| 15 | Poly(thiourea triethylene glycol) as a multifunctional binder for enhanced performance in lithium-sulfur batteries显示文摘A mechanically strong binder with polar functional groups could overcome the dilemma of the large volume change during charge/discharge processes and poor cyclability of lithium-sulfur batteries(LSBs).In this work,for the first time,we report the use of poly(thiourea triethylene glycol)(PTTG)as a multifunctional binder for sulfur cathodes to enhance the performance of LSBs.As expected,the PTTG binder facilitates the high performance and stability delivered by the Sulfur-PTTG cathode,including a higher reversible capacity of 825 mAh g^(-1) at 0.2 C after 80 cycles,a lower capacity fading(0.123%per cycle)over 350 cycles at 0.5 C,a higher areal capacity of 2.5 mAh cm^(-2) at 0.25 mA cm^(-2),and better rate capability of 587 mAh g^(-1) at 2 C.Such superior electrochemical performances could be attributed to PTTG's strong chemical adsorption towards polysulfides which may avoid the lithium polysulfide shuttle effect and excellent mechanical characteristics which prevents electrode collapse during cycling and allows the Sulfur-PTTG electrode to maintain robust electron and ion migration pathways for accelerated redox reaction kinetics. | Luke Hencz Hao Chen Zhenzhen Wu Xingxing Gu Meng Li Yuhui Tian Su Chen Cheng Yan Abdulaziz S.R.Bati Joseph G.Shapter Milton Kiefel Dong-Sheng Li Shanqing Zhang | 2022 | Green Energy & Environment2022，7，6： | 0 |
| 16 | Supramolecular fabrication of hyperbranched polyethyleneimine toward nanofiltration membrane for efficient wastewater purification显示文摘Nanofiltration technology has opened an efficient pathway to addressing the grand issue of wastewater purification.Polyethyleneimine(PEI),as a hydrophilic polymer,is a promising material to manufacture separation membranes owing to its superiority.Here,we prepared a hyperbranched PEI-based separation mem-brane through the supramolecular hydrogen bond interaction for wastewater purification.The amino groups in the PEI molecule were partially oxidized to the nitro groups with sodium hypochlorite(NaClO).Moreover,the PEI molecu-lar chains can be regulated from the hyperbranched state to the internal nucle-ation state.Molecular dynamics simulation results further indicated the strong hydrogen bonds among the oxidized PEI(O-PEI)molecular chains and the decreased gyration radius of the O-PEI molecule due to the formation of the nitro groups.In addition,the wettability and zeta potential of O-PEI membranes can be controlled by adjusting the molecular weight and oxidation degree of the PEI molecules.Under the collective effect of size screening and charge repulsion,the O-PEI separation membrane displayed a wide range of purification capabilities for contaminations,such as dye molecules and salts.This work may offer a new strategy to fabricate hyperbranched O-PEI membranes for wastewater purifica-tion. | Junyuan Xia Jincui Gu Peng Xiao Chang Zhang Luke Yan Tao Chen | 2021 | SusMat2021，1，4： | 0 |
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