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| 1 | Depletion of activated hepatic stellate cell correlates with severe liver damage and abnormal liver regeneration in acetaminophen-induced liver injury显示文摘肝的星形的房间(HSC ) 是为肝的祖先房间(HPC ) 和 hepatocytes 的本地干细胞壁龛的重要部分。然而,它至于激活的 HSC 的产品是否被要求稀释 hepatocyte 损害是不清楚的,提高肝新生,或两个。在这研究,我们由弄空执行了功能研究的损失有 gliotoxin 的激活的 HSC。显著地严重的肝损坏和拒绝的幸存率与激活的 HSC 的弄空被相关,这被表明。而且,减少 HSC 激活导致了增殖的 hepatocytes 的数字的 hepatocyte apoptosis 和 66% 减少的 3 褶层增加。这被戏剧的减少在知道在 hepatocyte 复制期间起来调整的五基因的表示层次伴随。特别地,激活的 HSC 的弄空禁止了被 Pank 积极的房间的减少的数字在道和降低的基因表示 cytokeratin 铺平的门附近证实的卵形的房间反应,这被发现 19 (CK19 ) 在对待 gliotoxin 的肝。这些数据提供激活的 HSC 涉及 hepatocyte 死亡和 hepatocytes 的增长,在 acetaminophen (APAP ) 的 HPC 导致了尖锐的肝损害的清楚的证据。 | Kuntang Shen Wenju Chang Xiaodong Gao Hongshan Wang Weixin Niu Lujun Song Xinyu Qin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 13 |
| 2 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 3 | Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR: simultaneous removal of nitrogen and antibiotics显示文摘 | Xiaoyan Song Rui Liu Lujun Chen Tomoki Kawagishi | 2017 | Frontiers of Environmental Science & Engineering2017，11，2： | 5 |
| 4 | Comparative study on microbial community in intermittently aerated sequencing batch reactors (SBR) and a traditional SBR treating digested piggery wastewater显示文摘 | Xiaolin Sheng Rui Liu Xiaoyan Song Lujun Chen Kawagishi Tomoki | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 3 |
| 5 | Proliferation and differentiation potential of mouse adult hepatic progenitor cells cultured in vitro显示文摘,这研究试图孤立干细胞或祖先存在,从正常成年老鼠肝并且调查他们增长和区别的潜力。Hepatocytes 被修改二拍子的圆舞肝灌注方法和 centrifugation 孤立,然后在为观察的修改包含浆液的 DMEM 有教养超过 60 天。Immunofluorescence 技术被使用检查 hepatocytes 并且与白朊, -fetoprotein (法新社) 和 cytokeratin 检验殖民地的形成 19 (CK19 ) 。结果显示出为 hepatocyte 是强烈积极的那一些 hepatocytes 在文化的白天 1 上的特定的标记白朊,能在天被激活 23,由殖民地的快速的增长和形成列在后面。殖民地能不断地膨胀超过 60 天。在白天 5 上,在殖民地的所有房间表示了肝的干细胞(HSC ) 标记法新社。与文化的时间,在殖民地的一些房间失去了能力在天划分 1315,并且区分了进有大细胞质和大约二个原子核的房间,类似于成熟 hepatocytes 的外观词法上。这些区分的房间表明了白朊的强壮的表示。在白天 30 附近,一些大房间在殖民地出现了并且表示了胆汁管房间标记 CK19。因此,老鼠 hepatocytes 的这 subpopulation 能获得不成熟的 hepatocytes 的一些特征并且与区别的一个高增殖能力和双性人潜力显示出肝的祖先房间的侧面。他们从因此,成年人老鼠说出成年肝的祖先房间(AHPC ) 的正常被孤立。老鼠 AHPC 可以为 hepatocytes 移植和 hepatopathy 学习被用作一个 HSC 模型。 | Lujun Song Hongshan Wang Xiaodong Gao Kuntang Shen Weixin Niu Xinyu Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 3 |
| 6 | Immunohistochemical expression of mTOR negatively correlates with PTENexpression in gastric carcinoma显示文摘 | Min Li Huawen Sun Lujun Song Xiaodong Gao Wenju Chang Xinyu Qin | 2012 | Oncology Letters2012，，6： | 2 |
| 7 | Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice显示文摘 | Xiaodong Gao Lujun Song Kuntang Shen Hongshan Wang Weixin Niu Xinyu Qin | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 8 | Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice 显示文摘 | Gao Xiaodong Song Lujun Shen Kuntang | 2008 | Biochem Biophys Res Commun2008，371，： | 1 |
| 9 | Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment of digested piggery wastewater显示文摘 | Xiaoyan Song Rui Liu Lujun Chen Baogang Dong Tomoki Kawagishi | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 1 |
| 10 | Chirality Inversion of Assemblies of Bio-based Surfactant Triggered by Metal Ions显示文摘 | ZHANG Lujun ZHANG Pei ZHANG Xiudong SONG Jinliang YANG Guanying JIANG Long HAN Buxing | 2018 | Chemical Research in Chinese Universities2018，34，2： | 0 |
| 11 | Simultaneous integrated dose reduction intensity-modulated radiotherapy effectively reduces cardiac toxicity in limited-stage small cell lung cancer显示文摘Objective:To assess the clinical outcomes and toxicities of once daily(QD)simultaneous dose reduction intensity-modulated radiotherapy(SDR-IMRT-QD;SDR-QD)versus conventional QD IMRT(C-QD)and twice daily(BID)IMRT in patients with limited-stage small cell lung cancer(LS-SCLC).Methods:After propensity score matching(PSM),a retrospective analysis involving 300 patients with LS-SCLC treated using SDR-QD,C-QD,or BID was performed from January 1,2014 to December 31,2019.The prescribed irradiation dose in the SDR-QD cohort was 60 Gy/PGTV and 54 Gy/PTV QD.The radiation dose was 60 Gy for both PGTV and PTV QD in the C-QD cohort.The radiation dose was 45 Gy for both PGTV and PTV in the BID cohort.Toxicities,short-term effects,and survival outcomes were recorded.A meta-analysis on the protective effects of pharmaceuticals for cardiac toxicities induced by anti-tumor therapy was performed.Results:The median overall survival time(MST)in the 3 cohorts were 32.7 months(SDR-QD),26.3 months(C-QD),and 33.6 months(BID);the differences between groups were statistically significant.Lower toxicities and doses to organs-at-risk(OARs)occurred in the SDR-QD and BID cohorts.Further,the cardiac dose dosimetric parameter Vheart40 was negatively associated with survival(r=-0.35,P=0.007).A Vheart40 value of 16.5%was recommended as a cut-off point,which yielded 54.7%sensitivity and 85.7%specificity for predicting negative survival outcomes.The meta-analysis indicated that pharmaceuticals significantly reduced the cardiac toxicities induced by chemotherapy,but not radiotherapy.Conclusions:SDR-QD was shown to have similar toxicities and survival compared with BID,but fewer toxicities and better survival than C-QD.In addition,cardiac dose exposure was negatively associated with survival.Thus,16.5%of the cardiac dosimetric parameter Vheart40 is recommended as the cut-off point,and a Vheart40>16.5%predicts poor survival. | Jing Luo Jiawei Song Li Xiao Jiajia Zhang Yipeng Cao Jun Wang Ping Wang Lujun Zhao Ningbo Liu | 2023 | Cancer Biology & Medicine2023，20，6： | 0 |
| 12 | Transient axonal glycoprotein-1 induces apoptosisrelated gene expression without triggering apoptosis in U251 glioma cells显示文摘Previous studies show that transient axonal glycoprotein-1, a ligand of amyloid precursor protein, increases the secretion of amyloid precursor protein intracellular domain and is involved in apoptosis in Alzheimer's disease. In this study, we examined the effects of transient axonal glycoprotein-1 on U251 glioma cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that transient axonal glycoprotein-1 did not inhibit the proliferation of U251 cells, but promoted cell viability. The terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that transient axonal glycoprotein-1 did not induce U251 cell apoptosis. Real-time PCR revealed that transient axonal glycoprotein-1 substantially upregulated levels of amyloid precursor protein intracellular C-terminal domain, and p53 and epidermal growth factor receptor mRNA expression. Thus, transient axonal glycoprotein-1 increased apoptosis-related gene expression in U251 cells without inducing apoptosis. Instead, transient axonal glycoprotein-1 promoted the proliferation of these glioma cells. | Haigang Chang Shanshan Song Zhongcan Chen Yaxiao Wang Lujun Yang Mouxuan Du Yiquan Ke Ruxiang Xu Baozhe Jin Xiaodan Jiang | 2014 | Neural Regeneration Research2014，9，5： | 0 |
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