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| 1 | Non-invasive diagnosis of liver fibrosis in chronic hepatitis C显示文摘Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision making.Although liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability.Over the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable performance.Besides the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy.In addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk.However,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions.These methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve accuracy.In this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice. | Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon Roberto José de Carvalho-Filho | 2014 | World Journal of Gastroenterology2014，20，11： | 11 |
| 2 | Autoantibodies in chronic hepatitis C: A clinical perspective显示文摘Non-organ-specific autoantibodies and thyroid autoantibodies have been frequently found in chronic carriers of hepatitis C virus(HCV). With respect to endomysial antibodies and tissue transglutaminase, it is controversial whether the prevalence of glutenrelated seromarkers is higher in patients with HCV. In such cases, in addition to acknowledging any currently existing autoimmune disease, recognizing the risk of the patient developing an autoimmune disease during interferon(IFN)-based treatment must be a principle concern. From a clinical point-of-view, the presence of autoantibodies arouses suspicion that an autoimmunedisease may be present or may be precipitated by IFNbased HCV treatment. In this paper, we review the prevalence of autoantibodies in individuals with hepatitis C, the clinical significance of these autoantibodies, and the approach recommended for such situations. | Janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon | 2015 | World Journal of Hepatology2015，7，8： | 11 |
| 3 | To screen or not to screen? Celiac antibodies in liver diseases显示文摘Celiac disease(CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, hepatitis B, hepatitis C, portal hypertension and liver cirrhosis. We evaluate recommendations for active screening for CD in patients with liver diseases, and the effect of a gluten-free diet in these different settings. Active screening for CD is recommended in patients with liver diseases, particularly in those with autoimmune disorders, steatosis in the absence of metabolic syndrome, noncirrhotic intrahepatic portal hypertension, cryptogenic cirrhosis, and in the context of liver transplantation. In hepatitis C, diagnosis of CD can be important as a relative contraindication to interferon use. Gluten-free diet ameliorates the symptoms associated with CD; however, the associated liver disease may improve, remain the same, or progress. | Janaína Luz Narciso-Schiavon Leonardo Lucca Schiavon | 2017 | World Journal of Gastroenterology2017，23，5： | 2 |
| 4 | Fighting iron deficiency anemia with iron-rich rice 显示文摘 | Lucca P Hurrell R Potrykus I | 2002 | Am Coll Nutr2002，21，3： | 1 |
| 5 | Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor alpha (TNFα) release in a rat brain显示文摘 | Dalle Lucca JJ Chavko M Dubick MA | | 0，，1： | 1 |
| 6 | Approaches to improving the bioavailability and level of iron in rice seeds显示文摘 | Lucca P Hurrell R Potrykus I | 2001 | Journal of the Science of Food and Agriculture2001，81，： | 1 |
| 7 | Comparison of endovenous treatment with an 810 nm laser versus conventional stripping of the great saphenous vein in patients with primary varicose veins显示文摘 | DE MEDEIROS CA LUCCAS GC | 2005 | Dermatol Surg2005，31，12： | 1 |
| 8 | Effect of different doses of hexavalent chromium on mandibular growth and tooth eruption in juvenile Wistar rats显示文摘 | De Lucca RC Dutrey PL Villarino ME | 2009 | Exp Toxicol Patho12009，61，： | 1 |
| 9 | Associazione di re- boxetine nella depressione resistente a SSRI: effect of re- boxetine augmentation in SSRI resistant patients 显示文摘 | Serretti A Lucca A Cusin C | 2001 | J Psy: Giorn di Psieopatol2001，7，1： | 1 |
| 10 | Surface characteristics of micro-ultrasonically machined (100) silicon显示文摘 | Klopfstein M J Ghisleni R Lucca D A | 2008 | International Journal of Machine Tools & Manufacture2008，48，34： | 1 |
| 11 | Emerging targets for the development of novel antifungal therapeutics显示文摘 | Groll AH Lucca AJD Walsb TJ | 1998 | Trend Microb1998，6，3： | 1 |
| 12 | Inflammatory markers in Alzheimer's disease and multi-infarct dementia显示文摘 | De Luigi A Fragiacomo C Lucca U | 2001 | Mech Ageing Dev2001，122，16： | 1 |
| 13 | Pattern of cell proliferation in the early stages of arm regeneration in the feather star Antendon mediterranea 显示文摘 | Candia-Carnevali M D Bonasom F Lucca E | 1995 | Exp Zool1995，272，： | 1 |
| 14 | Photocatalytic activity of nanoneedles, nanospheres, and polyhedral shaped ZnO powders in organic dye degradation processes显示文摘 | Felipe Antonio Lucca Sánchez Antonio Shigueaki Takimi Fabiano Severo Rodembusch Carlos Pérez Bergmann | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 15 | Nanoindentation: Measuring Methods and Applications 显示文摘 | LUCCA D A HERRMANN K KLOPFSTEIN M J | 2010 | ManufacturingTechnology2010，，59： | 1 |
| 16 | Genetic engineering approaches to improve the bioavailibility and the level of iron in rice grains显示文摘 | LUCCA P HURRELL R POTRYKUS I | 2001 | Theor Appl Genet2001，102，： | 1 |
| 17 | Ameloblastic carcino- ma of the maxilla: a report of 2 cases显示文摘 | Lucca M D'Innocenzo R Kraus J A | 2010 | J Oral Maxillofac Surg2010，68，10： | 1 |
| 18 | Per unit length parameters of a multiconductor line with earth return inside a tunnel显示文摘 | Giovanni Lucca | 2000 | IEEE Transactions on Electromagnetic Compatibility2000，42，1： | 1 |
| 19 | Flow injection spectrophotometric, determination of A1 in hemodialysis solutions显示文摘 | RODRIGUES J L DE MAGALNAES C S LUCCAS P O | 2005 | J Pharm Biomed Anal2005，36，5： | 1 |
| 20 | Antifungal peptides:novel therapeutic compounds against emerging pathogens显示文摘 | Anthony J De Lucca Thimas JW | 1999 | Antimicrob Agents Chemother1999，43，1： | 1 |
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