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| 1 | Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer显示文摘Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.In this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of CRPC.By combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic effects.From nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and chemotherapy.Doxorubicin(DOX)was selected as the chemotherapeutic agent for cytotoxicity.In terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug delivery.The nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)irradiation.Through the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in vitro.This work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision. | Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu | 2023 | Nano Research2023，16，7： | 2 |
| 2 | Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression显示文摘A well-established role of cyclic GMP-AMP synthase(cGAS)is the recognition of cytosolic DNA,which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes(STING)-dependent innate immune response.Recent advance has also revealed that cGAS may be involved in several noninfectious contexts by localizing to subcellular compartments other than the cytosol.However,the subcellular localization and function of cGAS in different biological conditions is unclear;in particular,its role in cancer progression remains poorly understood.Here we show that cGAS is localized to mitochondria and protects hepatocellular carcinoma cells from ferroptosis in vitro and in vivo.cGAS anchors to the outer mitochondrial membrane where it associates with dynamin-related protein 1(DRP1)to facilitate its oligomerization.In the absence of cGAS or DRP1 oligomerization,mitochondrial ROS accumulation and ferroptosis increase,inhibiting tumor growth.Collectively,this previously unrecognized role for cGAS in orchestrating mitochondrial function and cancer progression suggests that cGAS interactions in mitochondria can serve as potential targets for new cancer interventions. | Shiqiao Qiu Xiuying Zhong Xiang Meng Shiting Li Xiaoyu Qian Hui Lu Jin Cai Yi Zhang Mingjie Wang Zijian Ye Huafeng Zhang Ping Gao | 2023 | Cell Research2023，33，4： | 2 |
| 3 | The Utilization and Application of Paraphrase in Basic College English Teaching in Zhejiang Province显示文摘Currently, colleges in China regard English as a compulsory course. It is necessary for both teachers and students to make efforts to develop their skills of English, such as paraphrase abilities during the teaching and learning of English. | Lu Shiting Li Xinyi | 2016 | 校园英语2016，，12： | 0 |
| 4 | Material patterning on substrates by manipulation of fluidic behavior显示文摘Patterned materials on substrates are of great importance for a wide variety of applications.In solution-based approaches to material patterning;fluidic flow is inevitable.Here we demonstrate not only the importance of fluidic behavior but also the methodology of engineering the flow pattern to guide the material crystallization and assembly.We show by both experiment and simulation that substrate heating;which is generally used to accelerate evaporation,produces irregular complex vortexes.Instead;a top-heating-bottom-cooling(THBC)set-up offers an inverse temperature gradient and results in a single Marangoni vortex,which is desired for ordered nanomaterial patterning near the contact line.We then realize the fabrication of large-scale patterns of iodide perovskite crystals on different substrates under THBC conditions.We further demonstrate that harnessing the flow behavior is a general strategy with great feasibility to pattern various functional materials ranging from inorganic;organic,hybrid to biological categories on different substrates,presenting great potential for practical applications. | Yitan Li Hao Wang Henglu Xu Shiting Wu Xuemei Li Jiapeng Yu Chaoyu Huang Zeyao Zhang Hao Sun Lu Han Meihui Li Anyuan Cao Zhenhai Pan Yan Li | 2019 | National Science Review2019，6，4： | 0 |
| 5 | Hierarchical TiO2 Flower-spheres with Large Surface Area and High Scattering Ability: an Excellent Candidate for High Efficiency Dye Sensitized Solar Cells显示文摘 | MA Jian YAO Shiting CHENG Pengfei DU Sisi SUN Yanfeng LIU Fengmin LU Geyu | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
| 6 | Lacanian Interpretation of Dorian Gray’s Self-Identifying under the Influence of Others显示文摘In Oscar Wilde's only novel The Picture of Dorian Gray,the protagonist Dorian Gray undergoes the psychological journey from ignorance to self-realization under the influence of Others including Lord Henry Wotton,artist Basil Hallward,and the magic portrait.It is due to the profound impact from the outside world that Dorian Gray alienates from his original self and remolds himself into an entity that is guided by Others.In interacting with Others,especially the intrusive patriarchal signifier,Dorian Gray acquires his self-identity through accepting and modulating his various images reflected in others'discourses,which can be interpreted in relation to the progression of three phases of Jacques Lacan's Mirror Stage Theory and three levels of semiotic complexity.A Lacanian reading of the early mirror stage of ego formation can be extended to better understand Dorian Gray's self-construction process on both a psychoanalytical and semiotic level,with an emphasis that Dorian Gray's journey to search for self is based on the powerful influence of the Others.The paper suggests that characters around Dorian Gray are playing respective roles of mother,father,and the mirror that dominate an infanfs seilf-identification between Lacanian Imaginary and Symbolic orders. | Shiting Lu | 2021 | Language and Semiotic Studies2021，7，2： | 0 |
| 7 | Random Terpolymer Based on Simple Siloxane-functionalized Thiophene Unit Enabling High-performance Non-fullerene Organic Solar Cells显示文摘Incorporation of siloxane-functionalized units into polymers backbone has proven to be an efficient strategy to improve photovoltaic performance. In this work, a low-cost siloxane-containing unit was developed to construct a series of terpolymers, and the effects of siloxane on the polymer performance were systematically studied. Different contents of thiophene containing siloxane-functionalized side chain were introduced into PM6 to obtain a series of polymers(PM6, PM6-SiO-10, PM6-SiO-20 and PM6-SiO-30). The siloxane-functionalized side chains in polymers have only a slight effect on the absorption behavior and frontier molecular orbitals. However, when the siloxane content increased, the terpolymers' aggregation property decreased and the temperature-dependency increased, leading to improved donor-acceptor compatibility. The power conversion efficiency(PCE) based on PM6:Y6, PM6-SiO-20:Y6 and PM6-SiO-30:Y6 devices was 15.64%, 16.03% and 15.82%, respectively. In comparison, the active layer based on PM6-SiO-10:Y6 exhibits the most appropriate phase separation morphology, resulting in effective exciton dissociation, more balanced hole-electron transport and less recombination. Consequently, the highest PCE of 16.69% with an outstanding shortcircuit current density of 26.96 mA·cm-2 was obtained, which are one of the highest values for siloxane-functionalized polymer-based devices.This work demonstrates that finely controlling the content of siloxane-functionalized thiophene is beneficial for obtaining high-performance terpolymer donors and provides a novel and low-cost method to improve photovoltaic performance. | Fuliang Cheng Shiting Lai Yihan Zhang Ling Xue Xinxin Xia Peipei Zhu Xinhui Lu Xunfan Liao Yiwang Chen | 2024 | Chinese Journal of Polymer Science2024，42，3： | 0 |
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