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| 1 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 3 | Thymosin alpha 1: isolation and sequence analysis of an immunologically active thymic polypeptide显示文摘 | GOLDSTEIN A L LOW T L MCADOO M | 1977 | Proc Natl Acad Sci USA1977，74，2： | 2 |
| 4 | Nutrient removal from eutrophic lake water by wetland filtration显示文摘 | Stites D L Lowe E F | 2002 | Ecological Engineering2002，19，2： | 1 |
| 5 | Industrial ecology and industrial ecosystems显示文摘 | LOWE E A EVANS L K | 1995 | Journal of Cleaner Production1995，3，1： | 1 |
| 6 | Lymph node status influences follow-up thyroglobulin levels in papillary thyroid cancer 显示文摘 | Low TH Delbridge L Sidhu S | 2008 | Ann Surg Oncol2008，15，10： | 1 |
| 7 | Coronary in-stent restenosis:current status and future strategies显示文摘 | LOWE H C OESTERLE S N KHACHIGIAN L M | 2002 | J Am Coll Cardiol2002，39，2： | 1 |
| 8 | The ecology of the European rabbit (Oyctolagus cuniculus) in coastal southwestern Australia显示文摘 | Twigg L E Lowe T J Martin G R | 1998 | Wildl Res1998，25，： | 1 |
| 9 | Pattern analysis with two dimensional spectral localization: application of two dimensional S-transform 显示文摘 | Mansinha L Stockwell R G Lowe R P | 1997 | Physic A1997，239，3： | 1 |
| 10 | Evaluation, Calibration and Verification of a Reinforced Concrete Beam-Column Joint Model 显示文摘 | Mitra N Lowes L N | 2007 | Journal of Structural Engineering ASCE2007，133，： | 1 |
| 11 | The SOMANZ Guidelines for the Management of Hypertensive Disorders of Pregnancy 2014 显示文摘 | Lowe SA Bowyer L Lust K | 2015 | Aust N Z J Obstet Gynaecol2015，55，1： | 1 |
| 12 | Fundamental impor- tance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node显示文摘 | Sanders L Rakovic S Lowe M | 2006 | J Physiol2006，571，3： | 1 |
| 13 | microRNAs join the p53 network--another piece in the tumour-suppression puzzle显示文摘 | He L He X Lowe SW | 2007 | Nat Rev Cancer2007，7，11： | 1 |
| 14 | Thermal cycling analysis of flip-chip solder joint reliability 显示文摘 | Pang J H L Chong D Y R Low T H | 2001 | Components and Packaging Technologies2001，24，4： | 1 |
| 15 | Localization ofthe complex spectrum: The S transform显示文摘 | Stockwell R G Mansinha L Lowe R P | 1996 | IEEE Transactions on Signal Processing1996，44，4： | 1 |
| 16 | Synthetic polyaspartic acid and its uses显示文摘 | Low K C Koskan L P | 1993 | Polym Mater Sci Eng1993，69，： | 1 |
| 17 | Morphological and Electrical Properties of Indium Tin Oxide Films Prepared at a Low Processing Temperature for Flexible Organic Light Emitting Devices显示文摘 | Zhu F R Zhang K Low B L | 2001 | Materials Science and Engineering B2001，85，： | 1 |
| 18 | Localization of the complex spectrum: the S transform显示文摘 | Stockwell R G Mansinha L Lowe R P | 1996 | IEEE Trans on Sig- nal Processing1996，44，4： | 1 |
| 19 | Preparation of mixed-matrix membranes for micellar enhanced ultrafiltration based on response surface methodology显示文摘 | Ngang H P Ahmad A L Low S C | 2012 | Desalination2012，293，： | 1 |
| 20 | CD117(KIT Receptor)expression in merkel cell carcinoma显示文摘 | Su LD Fullen DR Lowe L | 2002 | Am J Dermatopathol2002，24，4： | 1 |
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