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| 1 | Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma显示文摘AIM: To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a casecontrol study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylorinegative patients.METHODS: H pylori CagA and parietal cell antibodies(PCAs), and serum pepsinogen Ⅰ (SPGI) levels were compared between patients with gastric cancer and controls who received endoscopic examination due to reasons other than gastrointestinal malignancy.RESULTS: The odds ratio (OR) for gastric cancer was2.9 (95% CI 1.4-5.8) in H pylori+ patients, and 2.4 (95%CI 1.2-4.9) in CagA+ patients. When results of H pylori and CagA antibodies were combined, OR increased to5.0 (95% CI 2.5-10.0). Furthermore, if cardia cancer patients were excluded, the OR increased to 6.8 (95% CI3.1-14.8). Among patients with a low SPGI level, the OR was 12.0 (95% CI 4.1-35.3). However, the risk was significant only in the older age group. The number of patients with low SPGI was significantly higher in H pylori-/CagA+ patients as compared to other cancer patients.CONCLUSION: Examination of both H pylori and CagA antibodies increases the OR for gastric cancer in our casecontrol study. CagA antibodies are important in detecting previous H pylori infection in advanced atrophic gastritis or cancer when spontaneous decline of H pylori antibodies occurs. SPGI may be helpful in screening elderly gastric cancer patients. | Arto Kokkola Johanna Louhimo Pauli Puolakkainen Henrik Alfthan Caj Haglund Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 2 | CEA, CA199 and CA724 improve the diagnostic accuracy in gastrointestinal cancers 显示文摘 | Carpelan- Holmstrom M Louhimo J Stenman UH | 2002 | Anticancer Res2002，22，4： | 1 |
| 3 | CEA,CA242,CA19-9,CA72-4 and hCGbeta in the diagnosis of recurrentcolorectal cance显示文摘 | Carpelan-Holmstrm M Louhimo J Stenman UH | 2004 | Tumour Biol2004，25，5： | 1 |
| 4 | The rectourogenital connection in anorectal malformations is an ectopic anal canal 显示文摘 | Rintala R Lindahl H Sariola H Rapola J Louhimo I | 1990 | J Pediatr Surg1990，25，6： | 1 |
| 5 | Immunohistochemical expression of Bcl-2, Ki-67, and p21 in patients with papillary thyroid cancer显示文摘 | Siironen P Nordling S Louhimo J | 2005 | Tumour Bio12005，26，1： | 1 |
| 6 | Preoperative hCG beta and CA72-4 are prognostic factors in gastric cancer显示文摘 | Louhimo J Kokkola A Alfthan H ctal | 2004 | Int J Cancer2004，111，6： | 1 |
| 7 | Cyclooxygenase--2 expres-sioncorrelates with poor prognosis in pancreatic cancer显示文摘 | Juuti A Louhimo J Nordling S | 2006 | J Clin Pathol2006，59，4： | 1 |
| 8 | Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer显示文摘 | JUUTI A LOUHIMO J NORDLING S | 2006 | J Clin Pathol2006，59，4： | 1 |
| 9 | CEA,CA242,CA 19-9,CA 72-4 and hCGbeta in the diagnosis of recurrent显示文摘 | Carpelan-Holmstrom M Louhimo J Stenman UH | 2004 | Tumour Biol2004，25，56： | 1 |
| 10 | The Novel WHO 2010 Classification for Gastrointestinal Neuroendocrine Tumours Correlates Well with the Metastatic Potential of Rectal Neuroendocrine Tumours显示文摘 | Jernman Juha V?lim?ki Matti J Louhimo Johanna Haglund Caj Arola Johanna | 2012 | Neuroendocrinology2012，，4： | 1 |
| 11 | CEA, CA 19-9 and CA 72-4 improve the diagnostic accu- racy in gastrointestinal cancers 显示文摘 | CARPELAN H M LOUHIMO J STENMAN U H | 2002 | Anticancer Res2002，22，4： | 1 |
| 12 | CEA,CA242, CA19-9, CA72 4 and hCGbeta in the diagnosis of recurrent colorectal cancer显示文摘 | Carpelan- Holmst rom M Louhimo J Stenman U H | 2004 | Tumour Biol2004，25，56： | 1 |
| 13 | Estimating the probability of cancer with several tumor markers in palients with colorectal disease显示文摘 | Carpelan Holmstrom M Louhimo J Stenman U H | 2004 | Oncology2004，66，4： | 1 |
| 14 | Gastric outlet obstruction in gastric cancer: A comparison of three palliative methods显示文摘 | Ilona Ker?nen Leena Kyl?np?? Marianne Udd Johanna Louhimo Anna Lepist? Jorma Halttunen Arto Kokkola | 2013 | Oncol2013，，8： | 1 |
| 15 | CEA,CA 19-9 and CA 72 -4 improve the diagnostic accuracy in gastrointestinal cancers显示文摘 | Carpelan-Holmstrom M Louhimo J Stenman UH | 2002 | Anticancer Res2002，22，4： | 1 |
| 16 | Does non-curative gas- trectomy improve survival in patients with metastatic gastric cancer?显示文摘 | Kokkola A Louhimo J Puolakkainen P | 2012 | J Surg Oncol2012，106，2： | 1 |
| 17 | The spectrum of Cantrell'ssyndrome 显示文摘 | Vanamo K Sairanen H Louhimo I | 1991 | Pediatr Surg Int1991，6，： | 1 |
| 18 | Prognostic factors in papillary thyroid cancer: an evaluation of 601 consecutive patients显示文摘 | Siironen P Louhimo J Nordling S | 2005 | Tumour Biol2005，26，2： | 1 |
| 19 | CEA,CA199 and CA72-4 improve the diagnostic accuracy in gastrointestinal cancers显示文摘 | Carpelan-Holm strom M Louhimo J Stenman UH | | 0，，04： | 1 |
| 20 | CEA, CA 19-9 and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers显示文摘 | CARPELAN H M LOUHIMO J STENMAN U H | 2002 | Anticancer Res2002，22，4： | 1 |
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