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| 1 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 2 | Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes显示文摘AIM: To investigate the quality of life following lapa-roscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients under-went laparoscopic Nissen fundoplication. Short-term outcome data including symptom response, side effects of surgery, endoscopy, and patient's perception of over-all success were collected prospectively. Long-term out-comes were investigated retrospectively in patients witha median follow-up of 10 years by assessment of reflux symptoms, side effects of surgery, durability of antire-flux surgery, need for additional treatment, patient's perception of success, and quality of life. Antireflux sur-gery was considered a failure based on the following criteria: moderate to severe heartburn or regurgitation; moderate to severe dysphagia reported in combination with heartburn or regurgitation; regular proton pump inhibitor medication use; endoscopic evidence of erosive esophagitis Savary-Miller grade 1-4; pathological 24-h pH monitoring; or necessity to undergo an additional surgery. The main outcome measures were short-and long-term cure rates and quality of life, with patient sat-isfaction as a secondary outcome measure. RESULTS: Conversion from laparoscopy to open sur-gery was necessary in 2.4% of patients. Mortality was zero and the 30-d morbidity was 7.6% (95%CI: 4.7%-11.7%). The median postoperative hospital stay was 2 d [interquartile range (IQR) 2-3 d]. Two hundred and forty-seven patients were interviewed for short-term analysis following endoscopy. Gastro-esophageal reflux disease was cured in 98.4% (95%CI: 95.9%-99.6%) of patients three months after surgery. New-onset dysphagia was encountered postoperatively in 13 patients (6.7%); 95% reported that the outcome was better after antireflux surgery than with preopera-tive medical treatment. One hundred and thirty-nine patients with a median follow-up of 10.2 years (IQR 7.2-11.6 years) were available for a long-term evalu-ation. Cumulative long-term cure rates were 87.7% (81.0%-92.2%) at 5 years and 72.9% (64.0%-79.9%) at 10 years. Gastrointestinal symptom rating scores and RAND-36 quality of life scores of patients with treatment success were similar to those of the general population but significantly lower in those with failed antireflux surgery. Of the patients available for long-term follow-up, 83% rated their operation a success. CONCLUSION: For the long-term, our results indicate decreasing effectiveness of laparoscopic antirefluxsurgery, although most of the patients seem to have an overall quality of life similar to that of the general population. | Ilmo Kellokumpu Markku Voutilainen Caj Haglund Martti Frkkil Peter J Roberts Hannu Kautiainen | 2013 | World Journal of Gastroenterology2013，19，24： | 7 |
| 3 | Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma显示文摘AIM: To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a casecontrol study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylorinegative patients.METHODS: H pylori CagA and parietal cell antibodies(PCAs), and serum pepsinogen Ⅰ (SPGI) levels were compared between patients with gastric cancer and controls who received endoscopic examination due to reasons other than gastrointestinal malignancy.RESULTS: The odds ratio (OR) for gastric cancer was2.9 (95% CI 1.4-5.8) in H pylori+ patients, and 2.4 (95%CI 1.2-4.9) in CagA+ patients. When results of H pylori and CagA antibodies were combined, OR increased to5.0 (95% CI 2.5-10.0). Furthermore, if cardia cancer patients were excluded, the OR increased to 6.8 (95% CI3.1-14.8). Among patients with a low SPGI level, the OR was 12.0 (95% CI 4.1-35.3). However, the risk was significant only in the older age group. The number of patients with low SPGI was significantly higher in H pylori-/CagA+ patients as compared to other cancer patients.CONCLUSION: Examination of both H pylori and CagA antibodies increases the OR for gastric cancer in our casecontrol study. CagA antibodies are important in detecting previous H pylori infection in advanced atrophic gastritis or cancer when spontaneous decline of H pylori antibodies occurs. SPGI may be helpful in screening elderly gastric cancer patients. | Arto Kokkola Johanna Louhimo Pauli Puolakkainen Henrik Alfthan Caj Haglund Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 4 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 5 | Single lamellar mechanics of the human lumbar anulus fibrnsus显示文摘 | Holzapfel GA Schulze-Bauer CAJ Feigl G | 2005 | Biomechanics and Modeling in Mechanobiology2005，3，： | 1 |
| 6 | Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer显示文摘 | Anna Sivula Anne Talvensaari-Mattila Johan Lundin Heikki Joensuu Caj Haglund Ari Ristim?ki Taina Turpeenniemi-Hujanen | 2005 | Breast Cancer Research and Treatment2005，，3： | 1 |
| 7 | Isobyakangelicin Angelate; A Novel Furanocoumarin from Peucedanum palustre显示文摘 | Vuorelat H Erdelmeier CAJ Nyiredy S | 1988 | Planta Medica1988，54，： | 1 |
| 8 | Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin Ⅰ/angiotensin Ⅱ conversion in patients with chronic heart failure显示文摘 | FARQUHARSON CAJ STRUTHERS AD | 2000 | Circulation2000，101，6： | 1 |
| 9 | Measurement of blood volume in surgical and intensive care practice 显示文摘 | Jones JG Wardrop CAJ | 2000 | Br J Anaesth2000，84，2： | 1 |
| 10 | Determination of propofol in low-volume samples by high-performanc liquid chromatography with fluorescence detection显示文摘 | Knibbe CAJ Koster VA Deneer VHM | 1998 | J Chrom Biomed Sci Appl1998，706，： | 1 |
| 11 | Contrast-enhanced fluid-attenuated inversion recovery imaging for leptomeningeal disease in children显示文摘 | Griffiths PD Coley SC Romanowski CAJ | 2003 | AJNR2003，24，4： | 1 |
| 12 | A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depres-sion显示文摘 | Zarate CAJ Singh JB Carlson PJ | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 13 | Liquid chromatographic determination of mebendazole and its metablites, aminomebendazole and hydroxy-mebendazole in eel muscle tissue 显示文摘 | Hajee CAJ Haagsma N | 1996 | J AOAC Int1996，79，3： | 1 |
| 14 | The Novel WHO 2010 Classification for Gastrointestinal Neuroendocrine Tumours Correlates Well with the Metastatic Potential of Rectal Neuroendocrine Tumours显示文摘 | Jernman Juha V?lim?ki Matti J Louhimo Johanna Haglund Caj Arola Johanna | 2012 | Neuroendocrinology2012，，4： | 1 |
| 15 | Axial dispersion in single-phase flow in a pulsed packed column containing structured packing显示文摘 | Koning Caj Hamersma | 1991 | Chemical Engineering Science1991，46，3： | 1 |
| 16 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity 显示文摘 | Medzhitov R Preston-Hurlburt P Janeway CAJ | 1997 | Nature1997，388，： | 1 |
| 17 | Coventional and surrogate light chains differentially regulate Igμ and Dμ heavy chain maturation and surface expression显示文摘 | Smith BP Roman CAJ | 2001 | J Immunol2001，167，7： | 1 |
| 18 | Decreased fibrinolytic poten-tial inbsouth women with ischaemic cerebrovascular disease 显示文摘 | Kain K Asian CAJ Carter AM | 2001 | British Journal of Haematology2001，114，： | 1 |
| 19 | Vascular remodeling and altered protein expression during growth of coronary collateral arteries显示文摘 | Wolf C Caj WJ Vosschulte R | 1998 | J Mol Cell Cardiol1998，30，11： | 1 |
| 20 | High performance liquid chromatographic determination of the anthelmintic mebendazole in eel muscle tissue显示文摘 | Steenbaar J G Hajee CAJ Haagsa N | 1993 | J Chromatogr1993，615，1： | 1 |
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