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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | PHOTOELECTROCHEMICAL STUDY OF PASSIVE LAYERS ON COPPER ELECTRODES IN SOME ALKALINE MEDIA显示文摘PHOTOELECTROCHEMICALSTUDYOFPASSIVELAYERSONCOPPERELECTRODESINSOMEALKALINEMEDIA①A.Kamkina,1,ZhouGuodinga,XuQunjiebandB.H.cLooaE... | A. Kamkina,1, Zhou Guodinga, Xu Qunjieb and B. H.c Loo a Electrochemical Research Group, Shanghai Institute of Electric Power, Shanghai 200090, P. R. China b Corrosion Prevention Center, East China University of | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 2 |
| 3 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 4 | Variability of QT dispersion measurements in the surface electrocardiogram in patients with acute myocardial infarction and in normal subjects 显示文摘 | Van de Loo A Arendts W Hohnloser SH | 1994 | Am J Cardiol1994，74，11： | 2 |
| 5 | Variability of QT dispersion measurements in the surface electrocardiograms in patients with acute myocardial infarction and normal subjects 显示文摘 | Arendts W Hohnloser SH | 1994 | Am J Cardiol1994，74，11： | 1 |
| 6 | Electroless copper plating on aglass substrate coated with ZnO lm under UV illumination显示文摘 | Yang Y A Wei Y B Loo B H | 1999 | ElectroanalyticalChemistry1999，，462： | 1 |
| 7 | Results of a phase I dose - escala- tion study using single - fraction stereotactie radiotherapy for lung tumors 显示文摘 | Le QT Loo BW Ho A | 2006 | J Thorac 0ncol2006，1，： | 1 |
| 8 | Variability of QT dispersion measurements in the surface electrocardiogram in patients with acute myocardial infarction and in normal subjects显示文摘 | Van de Loo A Arendts W Hohnloser S H | 1994 | Am J Cardiol1994，74，11： | 1 |
| 9 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 10 | Dis- ease-specific quality-of-life questionnaires in rhinitis and rhinosinusitis 显示文摘 | Dietz de Loos DA Segboer CL Gevorgyan A | 2013 | Curr Allergy Asthma Rep2013，13，2： | 1 |
| 11 | Curing of epoxy matrix composites 显示文摘 | LOOS A C SPRINGER G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 12 | Technical note visible -light photochromism in electrolytically pretreated WO3 thin films 显示文摘 | Yang Y A Cao Y W Loo B H | 1998 | J Phys Chem Solids1998，59，9： | 1 |
| 13 | Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging 显示文摘 | Alfons S K de Hooqe Fons A J van de Loo | 2005 | Osteoarth Cartilage2005，13，1： | 1 |
| 14 | Streptococcus gordonii biofilm formation: identification of genes that code for biofilm phenotypes显示文摘 | LOO C Y CORLISS D A GANESHKUMAR N | 2000 | Journal of Bacteriology2000，182，5： | 1 |
| 15 | Gas-phase coordination properties of Zn^2+ Cu^2+ Ni^2+ and Co^2+ with histidine-eontaining peptides显示文摘 | Hu P Loo J A | 1995 | J Am Chem Soc1995，117，11： | 1 |
| 16 | A double-blind, randomized comparative trail of amisulpride versus olanzapine for 6 months in the treatment of schizophrenzia显示文摘 | Mortimer A Martin S Loo HH | 2004 | Int Clin Psychopharmacol2004，19，2： | 1 |
| 17 | A novel HSP90 modulator with selective activity against thyroid cancers in vitro显示文摘 | Sainadi A Loo P Mukelji R | 2009 | Surgely2009，146，： | 1 |
| 18 | Activity of Candida rugosa lipase immobilized on γ-Fe2O3 magnetic nanoparticles显示文摘 | DYAL A LOOS K NOTO M | | 0，，07： | 1 |
| 19 | Curing of Epoxy Matrix Composites显示文摘 | Loos A C Springer G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 20 | Interleukin-17 acts independently of TNF-alpha under arthritic conditions显示文摘 | Koenders M I Lubberts E van de Loo F A | 2006 | J Immunol2006，176，10： | 1 |
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