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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | PHOTOELECTROCHEMICAL STUDY OF PASSIVE LAYERS ON COPPER ELECTRODES IN SOME ALKALINE MEDIA显示文摘PHOTOELECTROCHEMICALSTUDYOFPASSIVELAYERSONCOPPERELECTRODESINSOMEALKALINEMEDIA①A.Kamkina,1,ZhouGuodinga,XuQunjiebandB.H.cLooaE... | A. Kamkina,1, Zhou Guodinga, Xu Qunjieb and B. H.c Loo a Electrochemical Research Group, Shanghai Institute of Electric Power, Shanghai 200090, P. R. China b Corrosion Prevention Center, East China University of | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 2 |
| 3 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 4 | Curing of epoxy matrix composites 显示文摘 | LOOS A C SPRINGER G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 5 | Streptococcus gordonii biofilm formation: identification of genes that code for biofilm phenotypes显示文摘 | LOO C Y CORLISS D A GANESHKUMAR N | 2000 | Journal of Bacteriology2000，182，5： | 1 |
| 6 | Curing of Epoxy Matrix Composites显示文摘 | Loos A C Springer G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 7 | Low-cost fabrication of advanced polymeric composites by resin infusion process 显示文摘 | Loos A C | 2001 | Advanced Composite Materials2001，10，23： | 1 |
| 8 | The Effects of Fluid Type and Viscosity on the Steady-state and Advancing Front Permeability Behavior of Textile Performs显示文摘 | Hammond V H Loos A C | 1997 | Journal of Reinforcement Plastics and Composites1997，16，1： | 1 |
| 9 | Notes on free-living and plant-parasitic nematodes of Ceylon 4显示文摘 | Loos C A | 1949 | Journal of the Zoological Society of India1949，，1： | 1 |
| 10 | Curing of epoxy matrix composites显示文摘 | LOOS A C SPRINGER G S | 1983 | Joumal of Composite Materials1983，17，2： | 1 |
| 11 | Thermal-oxidative aging effects on the properties of a carbon fiber-reinforced phenylethynyl-terminated poly ( etherimide ) 显示文摘 | Bullions T A McGrath J E Loos A C | 2003 | Composites Science and Technology2003，63，12： | 1 |
| 12 | Heat of reaction,degree of cure,and viscosity of Hercules 3501-6 resin显示文摘 | LEE W I LOOS A C SPRINGER G S | 1982 | Journal of Composite Materials1982，16，6： | 1 |
| 13 | A chemiluminescence enzyme immunoassay (CLEIA) for the determination of medroxyprogesterone acetate in buman serum显示文摘 | KIM J K ADAM A LOO J C | 1995 | Journal of Pharmaceutical and Biomedical Analysis1995，13，： | 1 |
| 14 | Curing of epoxy matrix composites显示文摘 | Loos A C Springer G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 15 | Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells显示文摘 | Wenzel A Franz C Breous E Loos U | 2005 | Mol Cell Endocrinol2005，244，12： | 1 |
| 16 | Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | van der WAL A C BECKER A E van der LOOS C M | 1994 | Circulation1994，89，3： | 1 |
| 17 | Fnumeration of 2,4-D degrading microorganisms in soils and crop plant rhizosphere using indication media:High populations associated with sugarcane(Saccharuw officinaruw)显示文摘 | SANDMANN I C LOOS M A | 1984 | Chemosphere1984，13，： | 1 |
| 18 | Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses 显示文摘 | Houtkamp M A de Boer O J van der Loos C M | 2001 | J Pathol2001，193，2： | 1 |
| 19 | Experimental and simulation investigation of RFID blind spots 显示文摘 | LOO C H ELSHERBENI A Z YANG F | 2009 | Journal of Electromagnetic Waves and Applications2009，，23： | 1 |
| 20 | Amino-functionalized nanoparticles as inhibitors of mTOR and inducers of cell cycle arrest in leukemia cells显示文摘 | Loos C Syrovets T Musyanovych A | 2014 | Biomaterials2014，35，6： | 1 |
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