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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | On the nature of methane gas-hydrate dissociation during the Toarcian and Aptian oceanic anoxic events显示文摘 | BEERLING D J LOMAS M R GROCKE D R | 2002 | American Journal of Sciences2002，302，： | 1 |
| 3 | Vegetation-climate feedbacks in a greenhouse world显示文摘 | Woodward F I Lomas M R Betts R A | 1998 | Philosophical Transactions of the Royal Society1998，353，： | 1 |
| 4 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998, and 1999events 显示文摘 | Gilbert P M Magnien R Lomas M W | 2001 | Estuaries2001，24，： | 1 |
| 5 | Protecting poorly chosen secrets from guessing attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE J Selected Areas Commun1993，11，5： | 1 |
| 6 | Protecting Poorly Chosen Secrets from Guessing Attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE Journal on Selected Areas in Communications1993，11，5： | 1 |
| 7 | Protecting Poorly Cho-sen Secrets from Guessing Attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE Journal on Se-lected Areas in Communications1993，11，： | 1 |
| 8 | The Impact of System Effects on Esti mation of Faraday Rotation from SAR Measurements 显示文摘 | Quegan S Lomas M R | 2015 | IEEE Transactions on Geoscience and Remote Sensing2015，53，8： | 1 |
| 9 | The Interaction between Faraday Ro ration and System Effects in SAR Measurements of Backscat- ter and Biomass显示文摘 | Quegan S Lomas M R | 2015 | lEEE Transactions on Geoscience and Re- mote Sensing2015，53，8： | 1 |
| 10 | Potential controls on interannual partitioning of organic carbon during the winter/ spring phytoplankton bloom at the Bermuda Atlantic time-series study (BATS) site显示文摘 | Lomas M W Bates N R | 2004 | Deep-Sea Research I: Oceanographic Research Papers2004，51，11： | 1 |
| 11 | Environmental genome shotgun sequencing of the Sargasso sea显示文摘 | Venter J C Remington K Heidelberg J F Halpern A L Rusch D Eisen J A Wu D Paulsen I Nelson K E Nelson W Fouts D E Levy S Knap A H Lomas M W Nealson K White O Peterson J Hoffman J Parsons R Baden-Tillson H Pfannkoch C Rogers Y H Smith H O | 2004 | Science2004，304，5667： | 1 |
| 12 | A lpha 1 antitryp sin polymerisation and the serp inopath ies:pathobio logy and prospects for treatment显示文摘 | Lomas DA M ahadeva R | 2002 | JClin Invest2002，110，： | 1 |
| 13 | Spatial and sea- sonal variability of primary production on the Eastern Bering Sea shelf显示文摘 | LOMAS M W MORAN S B CASEY J R | 2012 | Deep Sea Research Part II:Topical Studies in Oceanog- raphy2012，65，6667： | 1 |
| 14 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland 显示文摘 | GLIBERT P M MAGNIEN R LOMAS M W | 2001 | Estuaries2001，24，： | 1 |
| 15 | Vegetation dynamics- simulating responses to climatic change显示文摘 | Woodward F I Lomas M R | 2004 | Biological Reviews2004，79，3： | 1 |
| 16 | Vegetation dynamics-simulating responses to climatic change 显示文摘 | Woodward F I Lomas M R | 2004 | Biological Reviews2004，79，3： | 1 |
| 17 | Protecting poorly chosen secrets from guessing attacks显示文摘 | Gong Li Lomas T M A Needham R M | 1993 | IEEE Journal on Selected Areas in Communication1993，11，5： | 1 |
| 18 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998, and 1999 events 显示文摘 | Gilbert P M Magnien R Lomas M W | 2001 | Estuaries2001，24，6： | 1 |
| 19 | Natural radiation exposure in UK dwellings显示文摘 | Wrixon AD Green B M R Lomas P R | 1988 | NRPB~R190 HMSO1988，，： | 1 |
| 20 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland,USA:Comparison of 1997,1998,and 1999 events显示文摘 | Glibert P M Magnien R Lomas M W Alexander J Tan C L Haramoto E Trice M Kana T M | 2001 | Estuaries2001，24，： | 1 |
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