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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998, and 1999events 显示文摘 | Gilbert P M Magnien R Lomas M W | 2001 | Estuaries2001，24，： | 1 |
| 3 | The history of ecosystem services in economic theory and practice: from early notions to markets and payment schemes 显示文摘 | GOMEZ-BAGGETHUN E GROOT R D LOMAS P L | 2010 | Ecological economics2010，69，6： | 1 |
| 4 | The History of Ecosys- tem Services in Economic Theory and Practice : From Early Notions to Mar- kets and Payment Schemes显示文摘 | Gomez - Baggenthun E De Grot R Lomas P L | 2010 | Ecological Economics2010，，69： | 1 |
| 5 | Magnetic resonance elastography by direct visualization of propagating acoustic strain waves显示文摘 | Muthupillai R Lomas D J Rossman P J | | 0，，5232： | 1 |
| 6 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland 显示文摘 | GLIBERT P M MAGNIEN R LOMAS M W | 2001 | Estuaries2001，24，： | 1 |
| 7 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998, and 1999 events 显示文摘 | Gilbert P M Magnien R Lomas M W | 2001 | Estuaries2001，24，6： | 1 |
| 8 | Correlated evolution of fig size and color supports the dispersal syndromes hypothesis显示文摘 | LOMA′SCOLO S B SPERANZA P KIMBALL R T | 2008 | Oecologia2008，156，： | 1 |
| 9 | Natural radiation exposure in UK dwellings显示文摘 | Wrixon AD Green B M R Lomas P R | 1988 | NRPB~R190 HMSO1988，，： | 1 |
| 10 | The history of ecoa ystem services in economic theory and practice:From early notions to markets and payment schemes显示文摘 | Gómez-Baggethun E Groot R D Lomas P L | 2010 | Ecological Economics2010，69，6： | 1 |
| 11 | Inhibitory conformation of the reactive loop ofα1-antitrypsin显示文摘 | ELLIOTT P R LOMAS D A CARRELL R W | 1996 | Nat Struct Mol Biol1996，3，8： | 1 |
| 12 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland,USA:Comparison of 1997,1998,and 1999 events显示文摘 | Glibert P M Magnien R Lomas M W Alexander J Tan C L Haramoto E Trice M Kana T M | 2001 | Estuaries2001，24，： | 1 |
| 13 | Environmental accounting as a management tool in the Mediterranean context: The Spanish economy during the last 20 years显示文摘 | Lomas P L Sergio A Marta R | 2008 | Journal of Environmental Management2008，88，： | 1 |
| 14 | Mul- ticompartment particle assemblies for bioinspired encapsula- ted reaetion显示文摘 | Chandrawati R van Koeverden M P Lomas H | 2011 | J Phys Chem Lett2011，2，20： | 1 |
| 15 | Magnetic resonance elastography by direct visualization of propagating acoustic strain waves显示文摘 | Muthupillai R Lomas D J Rossman P J | | 0，，5232： | 1 |
| 16 | Solar radiation transport through slat-type blinds: A new model and its application for thermal simulation of buildings 显示文摘 | Pfrommer P Lomas K J Kupke C H R | 1996 | Solar Energy1996，57，2： | 1 |
| 17 | Magnetic resonance imaging of transverse acoustic strain waves显示文摘 | Muthupillai R Rossman P J Lomas D J | | 0，，： | 1 |
| 18 | The history of ecosystem services in economic theory and practice:From early notions to markets and payment schemes显示文摘 | Góez-Baggethun E de Groot R Lomas P L | 2010 | Ecological Economics2010，69，： | 1 |
| 19 | Harmful algal blooms in the chesapeake and coastal bays of Maryland, USA: Comparison of 1997,1998 ,and 1999 events显示文摘 | GLIBERT P M MAGNIEN R LOMAS M W | 2001 | Estuar- ies and Coasts2001，24，6： | 1 |
| 20 | Harmful algae blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998 and 1999 events显示文摘 | GILBERT P M MAGNIEN R LOMAS M W | 2001 | Estuaries2001，24，： | 1 |
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