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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Interactions between NH4 and NO3 uptake and assimilation: Comparison of diatoms and dinoflagellates at several growth temperature显示文摘 | LOMAS M W GLIBERT P M | 1999 | Mar Biol1999，133，： | 2 |
| 3 | Organic nitrogen uptake and growth by the chrysophyte Aureococcus anophagefferens during a brown tide event显示文摘 | BERG G M GLIBERT P M LOMAS M W | 1997 | Marine Biology1997，129，： | 1 |
| 4 | Organic nitrogen up take and growth by the chrysophyte Aureococcus anophageens during a brown tide event显示文摘 | BERG G M GLIBERT P M LOMAS M W | 1997 | Marine Biology1997，129，： | 1 |
| 5 | On the nature of methane gas-hydrate dissociation during the Toarcian and Aptian oceanic anoxic events显示文摘 | BEERLING D J LOMAS M R GROCKE D R | 2002 | American Journal of Sciences2002，302，： | 1 |
| 6 | Light intensity regulation of cab gene transcription is signaled by the redox state of the plastoquinone pool 显示文摘 | Escoubas J M Lomas M LaRoche J | 1995 | Proceedings of the National Academy of Sciences of the United States of America1995，92，10： | 1 |
| 7 | Elevated organic nutrient ratios associated with brown tide blooms of Aureococcus anophagefferens (Pelagophyceae)显示文摘 | LOMAS M W GLIBERT P M CLOUGHERTY D A | 2001 | Journal of Plankton Research2001，23，： | 1 |
| 8 | Ahered hierarchy of protective re- sponses against severe hypoglycemia in normal ageing in healthy men显示文摘 | Matyka K Evans M Lomas J | 1997 | Diabetes Care1997，，20： | 1 |
| 9 | Mediation ofbenthic -pelagic coupling by microphytobenthos ; an energy- andmaterial-based model for initiation of blooms of Aureococcusanophagefferens 显示文摘 | MACINTYRE H L LOMAS M W Cornwell J | 2004 | Harmful Algae2004，3，40： | 1 |
| 10 | Dynamic simulation of human heat transfer and thermal comfort 显示文摘 | FIALA D LOMAS K J STOHRER M | | Environmental Ergonomics )ill 13iomed ldublJana0，，： | 1 |
| 11 | Ele-vated organic nutrient ratios associated with brown tide algalblooms of Aureococcus anophagefferens ( Pelagophyceae) 显示文摘 | LOMAS M W GILBERT P M CLOUGHERTY D A | 2001 | Journal of Plankton Research2001，23，12： | 1 |
| 12 | Vegetation-climate feedbacks in a greenhouse world显示文摘 | Woodward F I Lomas M R Betts R A | 1998 | Philosophical Transactions of the Royal Society1998，353，： | 1 |
| 13 | Interactions between NH4 and NO3 uptake and assimilation: Comparison of diatoms and dinoflagellates at several growth temperature 显示文摘 | Lomas M W Glibert P M | 1999 | Mar Biol1999，133，： | 1 |
| 14 | Aberrant methylation of multiple genes in neuroblastic tumors:relationship with MYCN amplification and allelic status atlp显示文摘 | Gonzalez-Gomez P Bello M J Lomas J | 2003 | European Jounal of Cancer2003，39，10： | 1 |
| 15 | Orgaic nitrogen uptake and growth by the chrysophyte Aureococcus anophagefferens during a brown tide event显示文摘 | Berg G M Glibert P M Lomas M W | 1997 | Marine Biology1997，129，： | 1 |
| 16 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland, USA: Comparison of 1997, 1998, and 1999events 显示文摘 | Gilbert P M Magnien R Lomas M W | 2001 | Estuaries2001，24，： | 1 |
| 17 | Organic nitrogen uptake and growth by the chrysophyte Aureococcus anophagefferens during a brown tide event显示文摘 | BERG G M GILBERT P M LOMAS M W | 1997 | Marine Biology1997，129，： | 1 |
| 18 | Protecting poorly chosen secrets from guessing attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE J Selected Areas Commun1993，11，5： | 1 |
| 19 | Interannualvariability of Aureococcus anophagefferens in Quantuck Bay, LongIsland :natural test of the DON hypothesis 显示文摘 | LOMAS M W KANA T M MACINTYRE HL | 2004 | Harmful Algae2004，3，38： | 1 |
| 20 | Total dissolved nitrogen anglysis:Comparisons between persulfate,UV,and high temperature oxidation methods显示文摘 | Bronk D A Lomas M W Glibert P M | 2000 | Marine Chemistry2000，69，： | 1 |
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