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| 1 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-l(27-35)显示文摘 | Castelli C Clayfi TM | 1996 | J Exp Med1996，184，： | 1 |
| 3 | Correlation of C - reactive protein with clinical, endoscopic, histologic, and radiographic activity in innammatory Bowel disease 显示文摘 | Solem C A Loftus E V Jr Tremaine W J et aJ | 2005 | Inflamm Bowel Dis2005，11，： | 1 |
| 4 | Influence of bone quality on stress distribution for endosseous implants显示文摘 | Holmes D C Loftus J T | 1997 | J Oral Implantol1997，23，3： | 1 |
| 5 | Correlation of C-reactive protein with clinical, endo- scopic, histologic and radiographic activity in inflamma- tory bowel disease显示文摘 | SOLEM C A LOFTUS E V JR TREMAINS W J | 2005 | Inflam Bowel Dis2005，11，： | 1 |
| 6 | Determination of plasma nefopam by liquid chromatography and electrochemical detection显示文摘 | Linda C Burton N J Loftus D | 1990 | J Chromatorgr1990，526，： | 1 |
| 7 | A simplified pathway for total knee arthroplasty improves outcomes显示文摘 | Loftus T Agee C Jaffe R | 2014 | J Knee Surg2014，27，3： | 1 |
| 8 | Hypertonic saline: a clinical review 显示文摘 | Tyagi R Donaldson K Loftus C M | 2007 | Neurosurgical review2007，30，4： | 1 |
| 9 | Effects of etomidate administration on cerebral collateral flow显示文摘 | Robertson S C Brown P Loftus C M | 1998 | Neurosurgery1998，43，2： | 1 |
| 10 | Transanal irrigation in the management of neurogenic bowel dysfunction 显示文摘 | Loftus C Wallace E McCaughey M | 2012 | Ir Med J2012，105，7： | 1 |
| 11 | Identification of Seniors at Risk (ISAR) Screening Tool in the emergency department: implementation using the plan-do-study-act model and validation results显示文摘 | Asomaning N Loftus C | 2014 | J Emerg Nurs2014，40，4： | 1 |
| 12 | Adipocyte differentiationand leption expression显示文摘 | Hwang C S Loftus T M Mandrup S | 1997 | Annu Rev Dev Biol1997，13，： | 1 |
| 13 | A β3 integrins mutation abolishes ligand binding and alters divalent cation-dependent conformation显示文摘 | Loftus J C O'Toole T E Plow E F | | 0，，： | 1 |
| 14 | Community structure of fishes inhabiting aquatic refuges in a threatened karst wetland and its implications for ecosystem management显示文摘 | Kobza R M Trexler J C Loftus W F | 2004 | Biological Conservation2004，116，2： | 1 |
| 15 | Management of ra- diation - induced accelerated carotid atherosclerosis 显示文摘 | LOFTUS C M BILLER J HART M N | 1987 | Arch Neurol1987，44，7： | 1 |
| 16 | Locked plates combined with minimal y invasive insertion technique for the treatment of periprosthetic supracondylar femur fractures above a total knee arthroplasty显示文摘 | Ricci WM Loftus T Cox C | | 0，，03： | 1 |
| 17 | Bilateral (mirror-image)aneurysms at the origin of the posteroinferlor eerebellar artery: casereport显示文摘 | WELLMAN B J LOFTUS C M | 1998 | Neurosurgery1998，42，： | 1 |
| 18 | Locked plates combined with minimally invasive insertion technique for the treatment of periprosthetic supracondylar femur fractures above a total knee arthroplasty 显示文摘 | Ricci W M Loftus T Cox C | 2006 | Orthop Trauma2006，20，3： | 1 |
| 19 | Locked plates combined with minimally invasive insertion technique for the treatment of periprosthetic supracondylar femur fractures above a total knee arthroplasty显示文摘 | Ricci WM Loftus T Cox C | 2006 | J Orthop Trauma2006，20，3： | 1 |
| 20 | Alethal perinatal cardiac phenotype resulting from al-tered integrin function in cardiomyocytes 显示文摘 | Valencik M L Keller R S Loftus J C McDonald J A | 2002 | J CardFail2002，8，： | 1 |
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