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| 1 | 从胚胎的干细胞塑造眼睛: 生物、医药的含意显示文摘 Organogenesis is regulated by a complex network of intrinsic cues, diffusible signals and cell/cell or cell/matrix interactions that drive the cells of a prospective organ to differentiate and collectively organize in three dimensions. Generating organs in vitro from embryonic stem (ES) cells may provide a simplified system to decipher how these processes are orchestrated in time and space within particular and between neighboring tissues. Recently, this field of stem cell research has also gained considerable interest for its potential applications in regenerative medicine. Among human pathologies for which stem cell-based therapy is foreseen as a promising therapeutic strategy are many retinal degenerative diseases, like retinitis pigmentosa and age-related macular degeneration. Over the last decade, progress has been made in producing ES-derived retinal cells in vitro, but engineering entire synthetic retinas was considered beyond reach. Recently however, major breakthroughs have been achieved with pioneer works describing the extraordinary self-organization of murine and human ES cells into a three dimensional structure highly resembling a retina. ES-derived retinal cells indeed assemble to form a cohesive neuroepithelial sheet that is endowed with the intrinsic capacity to recapitulate, outside an embryonic environment, the main steps of retinal morphogenesis as observed in vivo. This represents a tremendous advance that should help resolving fundamental questions related to retinogenesis. Here, we will discuss these studies, and the potential applications of such stem cell-based systems for regenerative medicine. | Gabriele Colozza Morgane Locker Muriel Perron | 2012 | World Journal of Stem Cells2012，4，8： | 2 |
| 2 | Ki67 immunoreactivity in breast carcinoma: relationships to prognostic variables and short term survival显示文摘 | Locker AP Birrell K Bell JA | 1992 | Eur J Surg Oncol1992，18，3： | 1 |
| 3 | ASCO 2006 update of recom- mendations for the use of tumor markers in gastrointestinal cancer显示文摘 | Locker GY Hamilton S Harris J | 2006 | J Clini Oncol2006，24，33： | 1 |
| 4 | Age of onset of dental anxiety显示文摘 | Locker D Liddell A Dempster L | 1999 | J Dent Res1999，78，3： | 1 |
| 5 | Low efficacy of serum levels CAI9 -9 in prediction of malignant diseases in asymptomatic population in Taiwan 显示文摘 | Locker G Y Huang S P Chiu H M | 2006 | Hepatogastro-enterology2006，53，67： | 1 |
| 6 | Factors influencing local recurrence after excision and radiotherapy far primary breast cancer 显示文摘 | Locker AP Ellis JO Morgan DAL | 1989 | Br J Surg1989，76，： | 1 |
| 7 | Disparities in oral health-related quality of life in a population of Canadian children 显示文摘 | Locker D | 2007 | Community Dent Oral Epidemiol2007，35，5： | 1 |
| 8 | Psychosocial consequences of dental tear and anxiety显示文摘 | Locker D | 2003 | Community Dent Oral Epidemiol2003，31，2： | 1 |
| 9 | Prostaglandin E( 1 ) does not influence plasmatic coagulation, hepatic synthesis, or postoperative blood loss in patients after coronary-artery bypass gra0ing显示文摘 | Locker G Grimm M Losert H | 2000 | Clin Anesth2000，12，5： | 1 |
| 10 | What do children's global ratings of oral health and well-being measure?显示文摘 | JOKOVIC A LOCKER D GUYATT G | 2005 | Commnity Dent Oral Epidemiol2005，33，3： | 1 |
| 11 | Label-free molecular imaging of atheroselerotie lesions using multimodal nonlinear optical microscopy显示文摘 | Le T T Langohr M I Locker M J | 2007 | Biomed Opt2007，12，05： | 1 |
| 12 | Self-reported dental and oral injuries in a population of adults aged 18-50 years显示文摘 | Locker D | 2007 | Dent Traumatol2007，23，5： | 1 |
| 13 | Increased serum concentration of soluble CD14 is a prognostic marker in gram-positive sepsis 显示文摘 | Burgmann H Winkler S Locker GJ | 1996 | Clinical Immunology and Immunopathology1996，80，3： | 1 |
| 14 | Femoral nerve infusion after primary total knee arthroplasty:aprospective,doubleblind,randomised and placebo-controlled trial显示文摘 | Wyatt M C Wright T Locker J | 2015 | Bone Joint Res2015，4，2： | 1 |
| 15 | A CroSS--cultural studyof oral health values 显示文摘 | Allison P Locker D Jokovic A | 1999 | J-Dent Res1999，78，2： | 1 |
| 16 | ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer显示文摘 | Locker G Y Hamilton S Harris J | 2006 | J Clini Oncol2006，33，： | 1 |
| 17 | Multiple arterial grafts improve late survival of patients undergoing coronary artery bypass graft surgery:analysis of 8622 pa- tients with multivessel disease 显示文摘 | LOCKER C SCHAFF H V DEARANI J A | 2012 | Circulation2012，126，9： | 1 |
| 18 | Prognostic value of hemodynamic vs big endothelin measurements during long-term Ⅳ therapy in advanced heart failure patients显示文摘 | Frey B Pacher R Locker G | | 0，，06： | 1 |
| 19 | GAL3 receptor KO mice exhibit an anxiety-like phenotype显示文摘 | Brunner SM Farzi A Locker F | 2014 | Proe Natl Acad Sci USA2014，111，19： | 1 |
| 20 | Applying high-resistance neutral grounding in medium-voltage systems显示文摘 | Kingrey L J Painter R D Locker A S | 2011 | IEEE Transactions on Industry Applications2011，47，3： | 1 |
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