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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 3 | Weighing the options in the pharmacotherapy of obesity 显示文摘 | Wieland H A Hamilton B S | 2001 | Int J Clin Pharmacol Therapeut2001，39，9： | 2 |
| 4 | Do inflammatory processes contribute to radiation-induced erythema observed in the skin of humans? 显示文摘 | Simonen P Hamilton C Ferguson S | 1998 | Radiother Oncol J1998，46，1： | 1 |
| 5 | Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinis acetycholine receptor显示文摘 | ZHANG Y DYCK R H HAMILTON S E | 2005 | Hear Res2005，201，： | 1 |
| 6 | A study of quality of life inprimigravidae with urinary incontinence显示文摘 | Dolan LM Walsh D Hamilton S | 2004 | Int Urogynecol J PelvicFloor Dysfunct2004，15，3： | 1 |
| 7 | Retroprosthetic membranes in AlphaCor patients,risk factors and prevention显示文摘 | Hicks CR Hamilton S | 2005 | Cornea2005，24，6： | 1 |
| 8 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 9 | Physical modeling of the step recovery diode for pulse and harmonic generation circuits显示文摘 | Moll J L Hamilton S A | 1969 | Proc of the IEEE1969，57，7： | 1 |
| 10 | C-2 neurec-tomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome 显示文摘 | Hamilton D K Smith J S Sansur C A | 2011 | J Neurosurg Spine2011，15，1： | 1 |
| 11 | Effect of pH on glucose and starch fermentation in batch and sequenced batch mode with a recently isolated strain of hydrogen-producing Clostridium butyricum CWBI1009 显示文摘 | Masset J Hiligsmann S Hamilton C | 2010 | International Journal of Hydrogen Energy2010，35，8： | 1 |
| 12 | Influenza virus-mediated membrane fusion:determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion显示文摘 | Hamilton BS Whittaker GR Daniel S | 2012 | Viruses2012，4，7： | 1 |
| 13 | ASCO 2006 update of recom- mendations for the use of tumor markers in gastrointestinal cancer显示文摘 | Locker GY Hamilton S Harris J | 2006 | J Clini Oncol2006，24，33： | 1 |
| 14 | The effect of published reports of unethical conduct on stock prices显示文摘 | RAO S M HAMILTON J B | 1996 | Journal of Business Ethics1996，，12： | 1 |
| 15 | The increasing linkage between US technology and public science 显示文摘 | Narin F Hamilton K S Olivastro D | 1997 | Research Policy1997，26，3： | 1 |
| 16 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 17 | Redox, pH and SP variation over mineralization in thick gla eial overburden显示文摘 | Hamilton S M Cameron E M McClenaghan M B | 2004 | Geochemistry: Exploration Environ ment AnaLysis2004，4，： | 1 |
| 18 | REACH:Clinicalfeasibility of a rural telestroke network显示文摘 | Hess DC Wang S Hamilton W | 2005 | Stroke2005，36，： | 1 |
| 19 | First Paper:Measurementof the Oil-film Thickness between the Piston Ringsand Liner of a Small Diesel Engine显示文摘 | Hamilton G M Moore S L | 1974 | Proceedings ofthe Institution of Mechanical Engineering1974，188，1： | 1 |
| 20 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
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