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| 1 | Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies显示文摘The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the brain.Among the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results.In addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc delivery.This review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain delivery.Based on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal administration.The results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried out.Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the brain.These systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years. | Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 2 | Alterations of the bloodretinal barrier and retinal thickness in preclinical retinopathy in subjects with type 2 diabetes显示文摘 | Lobo CL Bernardes RC Cunha-Vaz JG | 2000 | Arch Ophthalmol2000，118，10： | 1 |
| 3 | Virulence traits and antibiotic resistance among enterococci isolated from Eurasian otter ( Lutra lutra )显示文摘 | Teresa Semedo-Lemsaddek Cláudia Silva Nóbrega Tania Ribeiro Nuno M. Pedroso Teresa Sales-Luís Abdelhak Lemsaddek Rogério Tenreiro Luís Tavares Cristina Lobo Vilela Manuela Oliveira | 2013 | Veterinary Microbiology (-)2013，，3： | 1 |
| 4 | Macular alterations after small-incision cataract surgery显示文摘 | Lobo CL Faria PM Soares MA Bernardes RC Cunha-Vaz JG | 2004 | JCataract Refract Surg2004，30，4： | 1 |
| 5 | Macular alterations after small-incision cataract surgery显示文摘 | Lobo CL Faria PM SoaresMA | | 0，，： | 1 |
| 6 | Three-year follow-up study of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative diabetic retinopathy显示文摘 | Lobo CL Bernardes RC Figueira JP | 2004 | Arch Ophthalmol2004，122，： | 1 |
| 7 | Alteration of the blood-retinal barrier and retinal thickness in preclinical retinopathy in subjects with type 2 diabetes显示文摘 | Lobo CL Bernades RC Cunha-Vaz JG | 2000 | Arch ophthalmol2000，118，10： | 1 |
| 8 | Reti- nal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus: comparison of measure- ments obtained by retinal thickness analysis and optical coher- ence tomography 显示文摘 | Pires I Bernardes RC Lobo CL Soares MA Cunha-Vaz JG | 2002 | Arch Ophthalmol2002，120，0： | 1 |
| 9 | Alterations of the blood-reti- nal barrier and retinal thickness in preelinieal retinopathy in subjects with type 2 diabetes 显示文摘 | Lobo CL Bemardes RC Cunha-Vaz JG | 2000 | Arch Ophthalmol2000，118，10： | 1 |
| 10 | Mapping retinal fluorescein leakage with confocal scanning laser fluorometry of the human vitreous 显示文摘 | Lobo CL Bemardes RC Santos FJ at al | 1999 | Arch Ophthalmol1999，117，5： | 1 |
| 11 | Deep venous thrombosis in children with sickle cell disease 显示文摘 | Boechat Tde O do Naseimento EM Lobo CL | 2015 | Pediatr Blood Caneer2015，62，5： | 1 |
| 12 | Macular alterations after small- incision cataract surgery显示文摘 | Lobo CL Faria PM SoaresMA | 2004 | J Cataract Refract Surg2004，30，： | 1 |
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