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| 1 | Large bowel injuries during gynecological laparoscopy显示文摘Laparoscopy is one of the most frequently preferred surgical options in gynecological surgery and has advantages over laparotomy, including smaller surgical scars, faster recovery, less pain and earlier return of bowel functions. Generally, it is also accepted as safe and effective and patients tolerate it well. However, it is still an intra-abdominal procedure and has the similar potential risks of laparotomy, including injury of a vital structure, bleeding and infection. Besides the wellknown risks of open surgery, laparoscopy also has its own unique risks related to abdominal access methods,pneumoperitoneum created to provide adequate operative space and the energy modalities used during the procedures. Bowel, bladder or major blood vessel injuries and passage of gas into the intravascular space may result from laparoscopic surgical technique. In addition, the risks of aspiration, respiratory dysfunction and cardiovascular dysfunction increase during laparoscopy. Large bowel injuries during laparoscopy are serious complications because 50% of bowel injuries and60% of visceral injuries are undiagnosed at the time of primary surgery. A missed or delayed diagnosis increases the risk of bowel perforation and consequently sepsis and even death. In this paper, we aim to focus on large bowel injuries that happen during gynecological laparoscopy and review their diagnostic and management options. | Kahraman ülker Turgut Anuk Murat Bozkurt Yetkin Karasu | 2014 | World Journal of Clinical Cases2014，2，12： | 9 |
| 2 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 3 | Using a web-based orthopaedic clinic in the curricular teaching of a German university hospital: Analysis of learning effect, student usage and reception显示文摘 | Markus Wünschel Ulf Leichtle Nikolaus Wülker Torsten Kluba | 2010 | International Journal of Medical Informatics2010，，10： | 2 |
| 4 | WRKY transcription factors: from DNA binding towards biological function显示文摘 | Bekir ülker Imre E Somssich | 2004 | Current Opinion in Plant Biology2004，，5： | 2 |
| 5 | Extracellular laccase in ascomycetes Trichoderma atroviride and Trichoderma harzianum显示文摘 | H(o)lker U Dohse J H(o)fer M | 2002 | Folia Microbiologica2002，47，2： | 1 |
| 6 | Colour Doppler ultrasonography to detect pannus in knee joint synovitis显示文摘 | Schmidt WA V(o)lker L Zacher J | | 0，，04： | 1 |
| 7 | Alveolar macrophage phagocytic activity is enhanced with LPS priming,and combined stimulation of LPS and lipoteichoic acid synergistically inducepro-inflammatory cytokines in pigs显示文摘 | Islam M A Prll M Hlker M | 2013 | Innate Immun2013，19，6： | 1 |
| 8 | Effects of temperature, swimming speed and body mass on standard and active metabolic rate in vendace (Coregonus albula) 显示文摘 | Ohlberger J Staaks G H?lker F | 2007 | Comparative Biochemistry and Physiology2007，177，8： | 1 |
| 9 | Exercise- induced apoptosis of lymphocytes depends on train- ing status 显示文摘 | Mooren F C Lechtermann A V? lker K | 2004 | Med Sci Sports Exerc2004，36，9： | 1 |
| 10 | Cytotoxicity testing of temporary luting cements with two-and three-dimensional cultures of bovine dental pulp-derived cells显示文摘 | lker HE lker M GümüH | 2013 | Biomed Res Int2013，2013，91： | 1 |
| 11 | Analysis of proximal radial nerve injury in the arm显示文摘 | DUZ B)LENT SOLMAZ LKER CIVELEK ERDIN | 2011 | Neurology India2011，58，2： | 1 |
| 12 | Cytotoxicity evaluation of dentin bonding agents by dentin barrier test on 3-dimensional pulp cells显示文摘 | Sengün A Yaln M lker HE | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，112，3： | 1 |
| 13 | Failures of hallux valgus surgery显示文摘 | Wülker N | 2011 | Orthopade2011，40，5： | 1 |
| 14 | Thromboeytosis after major lower extremity trauma:mechanism and possible role in free flap failure显示文摘 | Choe E I Kasabian A K Ko lker A R | 1996 | Ann Plast Surg1996，36，5： | 1 |
| 15 | A systematic review of the epidemiology and interaction ofherpes simplex virus types 1 and 2显示文摘 | Lker KJ Garnett GP | 2005 | Sex Transm Infect2005，81，2： | 1 |
| 16 | Laboratory for power quality analysis显示文摘 | Julio Barros Daniel Cando Lker Durana | 2001 | International Journal of Electrical Engineering Education2001，38，3： | 1 |
| 17 | An Electromagnetism-like Mechanism for Global Optimization显示文摘 | ? ?lker Birbil Shu-Chering Fang | 2003 | Journal of Global Optimization2003，，3： | 1 |
| 18 | Biotechnological advantages of laboratory-scale solid-state fermentation with fungi显示文摘 | U. H?lker M. H?fer J. Lenz | 2004 | Applied Microbiology and Biotechnology2004，，2： | 1 |
| 19 | Hydrological modeling of Seydi Suyu watershed (Turkey) with HSPF显示文摘 | Mine Albek U¨ lker Bakir O¨ gˇu¨tveren Erdem Albek | 2004 | Journal of Hydrology2004，285，： | 1 |
| 20 | Lexikon der Romanistischen Linguistik显示文摘 | H·lker K.Franzosisch Partikelforschung | | 0，，： | 1 |
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