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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | 实验小鼠不是最好的动物模型?显示文摘实验小鼠作为研究人类疾病的动物模型,在生物、医学领域沿袭已久。而最近这个概念受到了挑战,在2016年4期的《自然》杂志上发表了一篇文章称,以无特定性病原体(SPF)级小鼠作为动物模型,可能并不是模拟成人免疫系统的最佳模型。 | Beura LK Hamilton SE Bi K 郑湃 贾光 | 2016 | 中华预防医学杂志2016，50，12： | 12 |
| 3 | 分形信号估计的最佳子波门限方法显示文摘本文提出了一种基于奈曼-皮尔逊(Neyman-Pearson)准则和最小均方误差准则的、估计淹没在加性白高斯噪声中的l/f类分形信号的最佳子波门限方法.计算机仿真结果证明了该方法的可行性和有效性. | 梅文博 Shar.,LK | 1998 | 电子学报1998，26，4： | 12 |
| 4 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 5 | 支气管收缩对支气管哮喘患者气道重塑的影响显示文摘背景和目的:支气管哮喘(简称哮喘)以气道结构改变为病理特征,即气道重塑。这些改变与长期临床转归较差相关,并且已被归因于嗜酸粒细胞性炎症。然而,体外研究结果表明,支气管收缩期间出现的压缩性机械力可能独立诱导气道重塑。本研究中评价了重复的实验诱导的支气管收缩对哮喘患者气道结构改变的影响。方法:将48例哮喘患者作为受试者,随机分入4种吸人激发方案之一, | Grainge CL Lau LK Ward JA 牟向东 迟春花 | 2012 | 中华结核和呼吸杂志2012，35，2： | 3 |
| 6 | SOME SUPERCONVERGENCE RESULTS OF WILSON-LIKE ELEMENTS显示文摘In this paper, the superconvergence of a class of Wilson-like elements is considered. A superconvergent estimate on the centers of elements and some superconvergence recoveries on the four ventices and the four midpoints of edges of elements are also obtained for piecewise strongly regular quadrilateral subdivisions. | Zhang, L Li, LK | 1998 | Journal of Computational Mathematics1998，16，1： | 3 |
| 7 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 8 | Interface Characterization of the SiCp/Al Composites Made by Powder Metallurgy显示文摘The interface of the SiCp/Al composites produced by powder metallurgy processing involving hotpressing above the matrix solidus temperature has been investigated by means of TEM. Several kinds of interfaces between the reinforcements and the matrix in the composite, including the clean interfaces, the faceted interfaces and the slight reaction intedeces, are presented. And most of interfaces belong to the slight reaction interfaces which are composed of the Al with different orientation from the Al matrix near the interface zone and particte-like substances produced by MgAl2O4 spinels and | Fan, JZ Zhang, K Shi, LK Zhang, SM | 1999 | Journal of Materials Science & Technology1999，15，2： | 2 |
| 9 | 老年冠心病危险程度评估指南显示文摘冠心病在临床上可有数种表现,医师应运用现代诊断方法,包括各种无创性及创伤性技术,对冠心病患者的预后及危险程度作出判断,以便为进行正确的治疗提供科学依据。本文将综述不同表现的冠心病患者危险程度的评估。 | Smith LK 钱方毅 | 1989 | 国外医学(老年医学分册)1989，10，6： | 2 |
| 10 | 在接受治疗的急性冠状动脉综合征患者中,肌钙蛋白峰值与长期缺血事件之间的关系显示文摘非ST段抬高急性冠状动脉综合征(acutecoro-narysyndromes,ACS)患者肌钙蛋白水平与结局的关系虽然已经明确,但接受抗血小板治疗管理的非ST段抬高ACS患者肌钙蛋白水平与长期结局的关系尚未明确。 | 刘莉 叶鹏 Goldstein SA Newby LK Cyr DD Neely M Lüscher TF Brown EB White HD Ohman EM Roe MT Hamm CW | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 11 | 人类巨细胞病毒感染显示文摘巨细胞病毒可引起免疫缺陷者和医源性免疫抑制的器官移植者多种类型的感染,也是引起艾滋病死亡的主要原因,为此对其进行广泛深入的研究。本文对巨细胞病毒的分子病毒学、免疫学,以及诊断和防治等方面的研究进行了较全面的综述. | Sissons JGP Borsiewicz LK 金玉怀 | 1990 | 国外医学(呼吸系统分册)1990，10，1： | 2 |
| 12 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 13 | Effect of total number of pulses of radial extracorporeal shock wave therapy (rESWT) on hamstring muscle spasticity in children with spastic type cerebral palsy: A randomized clinical trial显示文摘Purpose To evaluate the efficacy and safety of radial extracorporeal shock wave therapy (rESWT) according to total number of pulses on hamstring muscle spasticity in children with spastic type cerebral palsy (CP).Methods This study is a randomized controlled trial consisting of thirteen patients with spastic CP, 9 males and 4 females, aged 5 to 14 years (mean age 9.2). Twenty-five spastic hamstring muscles were divided in four groups. Group I: 500 pulses, Group II: 1, 000 pulses, Group III: 1, 500 pulses, and Group IV: 2, 000 pulses. Australian Spasticity Assessment Scale (ASAS) was measured at four different time points (pre-ESWT, post-ESWT, 2 weeks post-ESWT, and 4 weeks post-ESWT).Results All four groups showed improvement in ASAS relative to pre-treatment, although only significant in Group III (1, 500 pulses). There were no statistically significant differences in ASAS between all four groups in pre-ESWT [|2(2)=3.907,P=0.272], immediately post-ESWT [|2(2)=1.250,P=0.741], 2 weeks post-ESWT vs pre-ESWT [|2(2)=3.367,P=0.338], and 4 weeks post-ESWT vs pre-ESWT [|2(2)=1.566,P=0.667].Conclusion The effect of rESWT on spastic hamstring in children with spastic CP is not dependent on the number of pulses. | Wardhani RK Wahyuni LK Laksmitasari B | 2022 | 中华物理医学与康复杂志2022，44，4： | 2 |
| 14 | Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein显示文摘 | Liang XH Kleeman LK Jiang HH | 1998 | J Virol1998，72，11： | 1 |
| 15 | A social influence model of consumer participation in network-and small-group-based virtual communities显示文摘 | Dholakia UM Bagozzi RP Pearo LK | 2004 | International Journal of Research in Marketing2004，21，： | 1 |
| 16 | Eating disturbances and outcome of gastric bypass surgery: a pilot study 显示文摘 | Hsu LK Sullivan SP Benotti PN | 1997 | Int J Disord1997，21，4： | 1 |
| 17 | A reevaluation of the validity of unrestrained plethysmography in mice显示文摘 | Lundblad LK Irvin CG Adler A | 2002 | J Appl Physiol2002，93，4： | 1 |
| 18 | Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus 显示文摘 | Hansen D Bennedbaek FN Hansen LK | 1999 | Eur J Endocrinol1999，140，6： | 1 |
| 19 | Prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion显示文摘 | Spaide RF Chang LK Klancnik JM | 2009 | Am J Ophthalmol2009，147，： | 1 |
| 20 | Exploiting marine actinomycete biosynthetic pathways for drug discovery显示文摘 | Moore BS Kalaitzis JA Xiang LK | 2005 | Antonie Van Leeuwenhoek2005，87，1： | 1 |
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