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| 1 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs显示文摘二维(2D ) 因为他们的高特定的表面区域和迷人的物理化学的性质, nanomaterials 在 biomedicine 的地里获得了巨大的注意。此处, 2D monolayered 两倍氢氧化物( MLDH ) nanosheets 被采用本地化 doxorubicin (纪录影片), anticancer 药,与一个装载能力象 3.6 mg 一样高??釯??鶋???????鐿骢鯡????鮪???銬????雞??????飝鱎?鶬微隬悑傘?辬?銬???颬疞???徬?????鶝?铍?鳓钫?鵀?亘??鎪蒠?????????斪?鎬頿??悑?讬鶝???墑???鎛??亘??宫?? | Xuan Mei Simin Xu Tongyang Hu Liuqi Peng Rui Gao Ruizheng Liang Min Wei David G. Evans Xue Duan | 2018 | Nano Research2018，11，1： | 2 |
| 3 | Influence and evaluation of saturated soil shield construction on existing highway显示文摘In order to study the shield construction under an existing highway,the initial displacement and the excess pore water pressure solution from Biot consolidation equation were used to derive the analytical solutions of the vertical deformation and pore water pressure of saturated soil caused by the frontal friction and side friction of the cutterhead.In addition,by introducing the layered method and combining it with other theoretical analytical equations,the expressions of total vertical deformation and total pore water pressure caused by tunnel excavation with different overlying materials were obtained.The simulation results on an engineering project showed that the angleαbetween the direction of the road and the propulsion axis of the shield had a significant influence on the surface settlement of the road.When the angleαwas increased,the settlement curve had higher variation;but the variation would not exceed the maximum settlement value above the shield axis.When the road was perpendicular to the shield axis,a critical point of the road bulging and settlement was formed above the incision.Due to the grinding resistance of the cutterhead,the pore water pressure under the roadbed was distributed asymmetrically on both sides of the shield axis. | Liuqi Xu Chongfu Wu Liwei Wang Shuangjun Xu | 2021 | Transportation Safety and Environment2021，3，1： | 0 |
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