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| 1 | Protective effects of effective ingredients of Danshen (Radix Salviae Miltiorrhizae)and Honghua (Flos Carthami)compatibility after rat hippocampal neurons induced by hypoxia injury显示文摘OBJECTIVE: To investigate the effective ingredients of Danshen(Radix Salviae Miltiorrhizae) and Honghua(Flos Carthami)(Danhong) on protective properties towards neonatal rat hippocampal neurons under hypoxia condition.METHODS: Primary culture of neonatal rat hippocampal neurons was used to model hypoxia damage on the hippocampus. Methyl thiazolyl tetrazolium(MTT) assay and preliminary experiments were conducted to identify the four effective ingredients of Danhong, along with the injection of positive drug onto hippocampal neurons at a non-toxic dosage level. The cultured cells were randomly divided into 12 groups: the normal group, model group,positive drug control group and nine compatibility groups of the four effective ingredients. Different test methods were applied to determine lactate dehydrogenasein(LDH), total superoxide dismutase(T-SOD), malondialdehyde(MDA), 6-keto prostaglandin F_(la)(6-keto-PGF_(1 a)), thromboxane B_2(TXB_2),mitochondrial membrane potential(MMP), free calcium ions concentration([Ca^(2 +)]i) and early onsetcell apoptosis.RESULTS: Different compatibility groups could inhibit the content of LDH and intracellular calcium overload, increase activity in T-SOD, decrease level of MDA and TXB2, improve level of 6-keto-PGF1 aand MMP, and prevent the early onset cell apoptosis.CONCLUSION: The compatibility of four effective ingredients of Danhong had protective effect toward hippocampi hypoxia. The mechanism might be related to inhibit oxidative stress damage and cell apoptosis, resist thrombosis, and reduce the intracellular calcium ion of overload. | Yu Li Wan Haofang Jin Weifeng Yang Jiehong Li Chang Dai Liuling Ge Lijun Zhou Huifen Wan Haitong He Yu | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 4 |
| 2 | Optimal design of the gas storage surface pipeline system with injection and withdrawal conditions显示文摘Underground natural gas storage(UNGS)is an important part of the natural gas supply system to ensure a balanced energy supply.The surface system,as an important part of the gas storage,undertakes the functions of gas injection and gas production of the gas storage,and its investment economy is of vital importance.In fact,the UNGS surface pipeline network has two-way injection and production characteristics,which is different from the one-way production characteristics of conventional oil&gas gathering and transportation systems.This paper takes the minimum investment of the pipeline network as the objective function,considers the gas injection and gas withdrawal flow conditions and esablishes a mixed integer non-linear programming model(MINLP)for the surface pipeline network of the UNGS to optimize its pipeline layout and diameter parameters.Constraints including the well affiliation,the number of stations,the gathering radius,the processing capacity and the flow/pressure equilibrium equations,are also taken into consideration.Taking an UNGS in China as an example,the results of the optimal structure and diameter of the pipeline network,as well as the pipe flow,node pressure,and maximum/minimum flowrate during gas injection and gas withdrawal are obtained.Finally,the effects of constraints such as processing capacity and radius on the structure layout and investment of the UNGS are analyzed,verifying the reliability and effectiveness of the model. | Jun Zhou Liuling Zhou Guangchuan Liang Shaobo Wang Tiantian Fu Xuan Zhou Jinghong Peng | 2021 | Petroleum2021，7，1： | 2 |
| 3 | Zinc finger nuclease: a newapproach for excising HIV-1 proviral DNA from infectedhuman T cells 显示文摘 | Qu X Wang P Ding D Wang X Zhang G Zhou X LiuL Zhu X Zeng H Zhu H | 2014 | Mol Biol Rep2014，41，9： | 1 |
| 4 | Morphological Characteristics and Nutrient Content of Fine Roots of 2-Year-Old and 3-Year-Old Eucalyptus grandis Plantation显示文摘[Objective]This study aimed to explore the morphological characteristics and nutrient content of fine roots of 2-year-old and 3-year-old Eucalyptus grandis plantation and investigate the correlation.[Method] Fine roots of 2-year-old and 3-year-old Eucalyptus grandis plantation were collected as experimental materials,to determine the root diameter (D),root length (L),specific root length (SRL) and contents of major nutrient elements N,P,K,Ca,Mg and C of fine roots (level1-5),study the morphological characteristics and major nutrient element content and investigate the correlation.[Result] The results showed that morphological differences of fine roots (level1-5) of Eucalyptus grandis plantation were great with the increase of root order,to be specific,D and L increased and SRL decreased with the increasing root order;SRL,L and D of 3-year-old Eucalyptus grandis plantation were greater than those of 2-year-old Eucalyptus grandis plantation. Contents of N,Ca,Mg and C of fine roots of 2-year-old and 3-year-old Eucalyptus grandis plantation showed consistent orders with the increase of root order:N and Mg contents were reduced,while Ca and C contents were enhanced;P and K contents varied with different forest ages;both 2-year-old and 3-year-old Eucalyptus grandis showed an order of C > K > Ca ( Mg) > N. Major nutrient element content and morphological characteristics of Eucalyptus grandis fine roots (level1-5) were extremely significantly correlated (P < 0. 01),SRL,L and D could be adopted as reference indices to evaluate nutrient status of Eucalyptus grandis.Required nutrients and fine root morphology of Eucalyptus grandis plantation changed with the increase of forest age,and the nutrient cycling and energy flow patterns also changed; major nutrient elements in fine roots of 2-year-old and 3-year-old Eucalyptus grandis plantation transferred in a different order from the growth order,therefore N fertilizer could be applied to improve the growth of fine roots.[Conclusion]This study laid the foundation for understanding the fine root morphology and nutrient variation pattern of Eucalyptus grandis plantation and enriching the response and adaptation mechanism theory of roots to environment,possessing important reference significance for the sustainable development of Eucalyptus grandis plantation. | Xiaoyu DUAN Xianwei LI Liuling ZHOU Weishuang WANG Hui CHEN | 2012 | Agricultural Biotechnology2012，1，6： | 0 |
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