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| 1 | Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation显示文摘Dendritic cells (DCs) are the most potent antigen-presen ting cells that play crucial roles in the regulation of immune response. Triptol ide, an active component purified from the medicinal plant Tripterygium wilfor dii Hook F., has been demonstrated to act as a potent immunosuppressive drug c apab le of inhibiting T cell activation and proliferation. However, little is known a bout the effects of triptolide on DCs. The present study shows that triptolide d oes not affect phenotypic differentiation and LPS-induced maturation of murine DCs. But triptolide can dramatically reduce cell recovery by inducing apoptosis of DCs at concentration as low as 10 ng/ml, as demonstrated by phosphatidylserin e exposure, mitochondria potential decrease, and nuclear DNA condensation. Tript olide induces activation of p38 in DCs, which precedes the activation of caspase 3. SB203580, a specific kinase inhibitor for p38, can block the activation of caspase 3 and inhibit the resultant apoptosis of DCs. Our results suggest that t he anti-inflammatory and immunosuppressive activities of triptolide may be due, in part, to its apoptosis-inducing effects on DCs. | LiuQ ChenT ChenH ZhangM LiN LuZ MaP CaoX | 2004 | 第二军医大学学报2004，25，9： | 41 |
| 2 | Where Does AlphaGo Go: From Church-Turing Thesis to AlphaGo Thesis and Beyond显示文摘An investigation on the impact and significance of the Alpha Go vs. Lee Sedol Go match is conducted, and concludes with a conjecture of the Alpha Go Thesis and its extension in accordance with the Church-Turing Thesis in the history of computing. It is postulated that the architecture and method utilized by the Alpha Go program provide an engineering solution for tackling issues in complexity and intelligence. Specifically,the Alpha Go Thesis implies that any effective procedure for hard decision problems such as NP-hard can be implemented with Alpha Go-like approach. Deep rule-based networks are proposed in attempt to establish an understandable structure for deep neural networks in deep learning. The success of Alpha Go and corresponding thesis ensure the technical soundness of the parallel intelligence approach for intelligent control and management of complex systems and knowledge automation. | Fei-Yue Wang Jun Jason Zhang Xinhu Zheng Xiao Wang Yong Yuan Xiaoxiao Dai Jie Zhang Liuqing Yang | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 44 |
| 3 | Data mining in Xu Runsan’s Traditional Chinese Medicine practice:treatment of chronic pelvic pain caused by pelvic inflammatory disease显示文摘OBJECTIVE:To research the Traditional Chinese Medicine(TCM)practice of Professor Xu Runsan for treatment of chronic pelvic pain(CPP)caused by sequelae of pelvic inflammatory disease(SPID)by data mining.METHODS:The medical records of inpatients at China-Japan Friendship Hospital confirmed to have CPP caused by SPID were collected(274 visits in total).The data extracted from the medical records were analyzed by frequency statistics,correlation analyses,cluster analyses,and complex network analyses.RESULTS:The most frequently used medicines were warm medicines,bitter medicines,and medicines distributed to the liver meridian.The most common medicinal combinations were Chishao(Radix Paeoniae Rubra)plus Huangqi(Radix Astragali Mongolici)plus Sanqi(Radix Notoginseng)and Ezhu(Rhizoma Curcumae Phaeocoulis);Guizhi(Ramulus Cinnamomi)plus Fuling(Poria)and Chishao(Radix Poeoniae Rubra);and Chaihu(Radix Bupleuri Chinensis)plus Zhishi(Fructus Aurantii Immaturus)and Gancao(Radix Glycyrrhizae).The most frequently used medicines were divided into four groups according to their efficacy;i.e.,medicines that could(a)warm meridians and free collateral vessels,(b)regulate Qi and free collateral vessels,(c)fortify the spleen and nourish blood and Qi,and(d)tonify Qi and activate blood.The most commonly used formulations were Guizhi FulingPill and Sini Powder.The core medicines extracted based on complex network analyses were Chishao(Radix Poeoniae Rubra),Sanqi(Radix Notoginseng),Hua ngqi(Radix Astragali Mongolica),Danshen(Radix Salviae Miltiorrhizae),Ezhu(Rhizoma Curcumae Phaeocaulis), Gancao(Radix Glycyrrhizae),Chaihu(Radix Bupleuri Chinensis),Guizhi(Romulus Cinnomomi),Shuizhi(Hirudo), Fuling(Poria),and Zhishi(Fructus Aurantii Immaturus).CONCLUSION:According to the TCM practice of Professor Xui,treatment of CPP caused by SPID should focus on dissolving stasis and obstructions using medicines that can activate blood,resolve stasis,regulate Qi,and dissipate adhesions.His prescriptions are often based on Guizhi Fuling Pill and Sini Powder.More blood-activating,stasis-resolving,or tonifying medicines could be used according to the accompanying symptoms or symptom patterns identified. | Liu Liuqing Yang Fang Xin Ling Jing Yan | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 20 |
| 4 | SIMO detection schemes for underwater optical wireless communication under turbulence显示文摘In underwater optical wireless communication(UOWC),a channel is characterized by abundant scattering/absorption effects and optical turbulence.Most previous studies on UOWC have been limited to scattering/absorption effects.However,experiments in the literature indicate that underwater optical turbulence(UOT)can cause severe degradation of UOWC performance.In this paper,we characterize an UOWC channel with both scattering/absorption and UOT taken into consideration,and a spatial diversity receiver scheme,say a singleinput–multiple-output(SIMO) scheme,based on a light-emitting-diode(LED) source and multiple detectors is proposed to mitigate deep fading.The Monte Carlo based statistical simulation method is introduced to evaluate the bit-error-rate performance of the system.It is shown that spatial diversity can effectively reduce channel fading and remarkably extend communication range. | Weihao Liu Zhengyuan Xu Liuqing Yang | 2015 | Photonics Research2015，3，3： | 16 |
| 5 | NMR-based damage characterisation of backfill material in host rock under dynamic loading显示文摘It is not uncommon that backfill material used in underground mining being exposed to repetitive dynamic stresses induced by blasting operations or rockburst events. Understanding the strength and fracture evolution of backfilled stopes is critical to maintain the long-term stope stability and ensure safe mining activities. This paper aims to study the damage evolution of the backfill material and its host rock behaviour under three-dimensional(3D) dynamic loading. Using a true-triaxial testing machine, multiple samples of backfill material enclosed by country rock were fabricated and tested under various dynamic loadings with different true-triaxial confining stress conditions. In addition, the nuclear magnetic resonance(NMR) measurement was conducted on the samples before and after exerting static and dynamic loading to obtain their porosity distribution changes. The experiment results suggested that with the increase of the dynamic loading, the porosity of the backfill sample goes through a two-stage process,which shows a slightly linear decrease and then followed by an exponential increase. The research findings can help understand the damage mechanism and fracture development of backfilled stopes and its host rock in deep underground mines, which are constantly subject to the combination of 3D static confining stress and dynamic loading. | Binglei Li Jiquan Lan Guangyao Si Guopeng Lin Liuqing Hu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 16 |
| 6 | MdATG18a overexpression improves basal thermotolerance in transgenic apple by decreasing damage to chloroplasts显示文摘High temperature is an abiotic stress factor that threatens plant growth and development.Autophagy in response to heat stress involves the selective removal of heat-induced protein complexes.Previously,we showed that a crucial autophagy protein from apple,MdATG18a,has a positive effect on drought tolerance.In the present study,we treated transgenic apple(Malus domestica)plants overexpressing MdATG18a with high temperature and found that autophagy protected them from heat stress.Overexpression of MdATG18a in apple enhanced antioxidase activity and contributed to the production of increased beneficial antioxidants under heat stress.Transgenic apple plants exhibited higher photosynthetic capacity,as shown by the rate of CO_(2) assimilation,the maximum photochemical efficiency of photosystem II(PSII),the effective quantum yield,and the electron transport rates in photosystems I and II(PSI and PSII,respectively).We also detected elevated autophagic activity and reduced damage to chloroplasts in transgenic plants compared to WT plants.In addition,the transcriptional activities of several HSP genes were increased in transgenic apple plants.In summary,we propose that autophagy plays a critical role in basal thermotolerance in apple,primarily through a combination of enhanced antioxidant activity and reduced chloroplast damage. | Liuqing Huo Xun Sun Zijian Guo Xin Jia Runmin Che Yiming Sun Yanfei Zhu Ping Wang Xiaoqing Gong Fengwang Ma | 2020 | Horticulture Research2020，7，1： | 9 |
| 7 | Overexpression of MdATG18a in apple improves resistance to Diplocarpon mali infection by enhancing antioxidant activity and salicylic acid levels显示文摘Marssonina apple blotch,caused by Diplocarpon mali,is one of the most serious diseases of apple.Autophagy plays a key role in pathogen resistance.We previously showed that MdATG18a has a positive influence on drought tolerance.Herein,we describe how overexpression(OE)of MdATG18a enhances resistance to D.mali infection,probably because less H2O2 but more salicylic acid(SA)is accumulated in the leaves of OE apple plants.Expression of chitinase,β-1,3-glucanase,and SA-related marker genes was induced more strongly by D.mali in OE lines.Transcript levels of other important MdATG genes were also drastically increased by D.mali in OE plants,which indicated increased autophagy activities.Taken together,these results demonstrate that OE of MdATG18a enhances resistance to infection by D.mali and plays positive roles in H2O2-scavenging and SA accumulations.Our findings provide important information for designing strategies which could induce autophagy to minimize the impact of this disease on apple production. | Xun Sun Liuqing Huo Xin Jia Runmin Che Xiaoqing Gong Ping Wang Fengwang Ma | 2018 | Horticulture Research2018，5，1： | 8 |
| 8 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 9 | MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer显示文摘 | Liuqing Yang Hongwei Liang Yanbo Wang Shanting Gao Kai Yin Zhijian Liu Xi Zheng Ying Lv Lei Wang Chen-Yu Zhang Xi Chen Guifang Xu Weijie Zhang Xiaoping Zou | 2016 | Protein & Cell2016，7，5： | 7 |
| 10 | Energy-saving PPM schemes for WSNs显示文摘Energy conservation is a critical problem in recently-emerging wireless sensor networks (WSNs). Pulse position modulation (PPM), as an exploring-worthy modulation format for energy efficiency, is tailored for WSNs into two schemes, mono-mode PPM and multi-mode PPM, in this paper. Resorting to an idealized system model and a practical system model, which combine the power consumptions in transmission and reception modules of nodes with the idealized and realistic battery characteristics, the battery energy efficiencies of mono-mode PPM and multi-mode PPM are evaluated and compared. To minimize the battery energy consumption (BEC), these schemes are further optimized in terms of constellation size M for a link in path-loss channels. Our analytical and numerical results show that considerable energy can be saved by multi-mode PPM; and the optimization performances of these schemes are noticeable at various communication distances though their optimization properties are different. | TANG QiuLing YANG LiuQing QIN TuanFa ZHANG ShuYi | 2008 | Science in China(Series F)2008，51，5： | 7 |
| 11 | Aeroelastic stability analysis of heated flexible panel subjected to an oblique shock显示文摘The critical conditions for aeroelastic stability and the stability boundaries of a flexible two-dimensional heated panel subjected to an impinging oblique shock are considered using theoretical analysis and numerical computations, respectively. The von-Karman large deflection theory of isotropic flat plates is used to account for the geometrical nonlinearity of the heated panel, and local first-order piston theory is employed in the region before and after shock waves to estimate the aerodynamic pressure. The coupled partial differential governing equations, according to the Hamilton principle, are established with thermal effect based on quasi-steady thermal stress theory.The Galerkin discrete method is employed to truncate the partial differential equations into a set of ordinary differential equations, which are then solved by the fourth-order Runge-Kutta numerical integration method. Lyapunov indirect method is applied to evaluate the stability of the heated panel. The results show that a new aeroelastic instability(distinct from regular panel flutter) arises from the complex interaction of the incident and reflected wave system with the panel flexural modes and thermal loads. What's more, stability of the panel is reduced in the presence of the oblique shock. In other words, the heated panel becomes aeroelastically unstable at relatively small flight aerodynamic pressure. | Liuqing YE Zhengyin YE Xiaochen WANG | 2018 | Chinese Journal of Aeronautics2018，31，8： | 7 |
| 12 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 13 | Nonpropagating Solitons in (2+1)-Dimensional Dispersive Long-Water Wave System显示文摘With the help of an extended mapping approach, a new type of variable separation excitation with three arbitrary functions of the (2+1)-dimensional dispersive long-water wave system (DLW) is derived. Based on the derived variable separation excitation, abundant non-propagating solitons such as dromion, ring, peakon, and compacton etc.are revealed by selecting appropriate functions in this paper. | FANGJian-Ping ZHENGChun-Long LIUQing | 2005 | Communications in Theoretical Physics2005，43，2： | 5 |
| 14 | 5G ENABLED VEHICULAR COMMUNICATIONS AND NETWORKING显示文摘Vehicular communications and networking(VCN)is considered a billion-dollar industry.Its development not only possesses economic value,but also has enormous social potential.The earliest vehicular network started from the dedicated short range networks,such as the IEEE 802.11p standard established at the beginning of this century.In recent years,the public access network based VCN has been rapidly advanced.For example,LTE-V based on 4G LTE is under standardization。 | xiang cheng rongqing zhang shanzhi chen jia li liuqing yang hongwei zhang | 2018 | China Communications2018，15，7： | 5 |
| 15 | Investigation on the threshold control of safety blasting vibration velocity for the extraction of complicated orebody under railway显示文摘爆炸的安全的阀值控制颤动速度是为在建设,道路,和水中的复杂矿石沉积物的地下的采矿的重要进程。根据排水量的相等的原则和集体点的速度,微分进化基于 3DEC 被提出动态分析,使计算更有效、精确。在铁路下面的复杂 orebody 的 3DEC 模型根据地志的地图和东方黄铁矿矿的地质的数据被建立。内部应力和排水量地的刺激反应分发被分析所在地的监视颤动排水量和集体点的速度数据表明。参数选择的可靠性,例如爆炸模拟波形,抑制的岩石,被识别。铁路的安全颤动速度与爆炸的安全的要求一致被设为 4.5 cm/s 规则。因此,在这个区域的单个阶段的炸药的最大的数量是 44.978 kg。模拟结果在对所在地的监视资料的好同意。701 铁路专辑线的排水量和解决都没被选择单个阶段的炸药的批评数量完成。 | Jiang Lichunt Hu Liuqing Lai Xiuying | 2011 | Mining Science and Technology2011，21，2： | 5 |
| 16 | A lincRNA switch for embryonic stem cell fate显示文摘 | Liuqing Yang Chunru Lin Michael G Rosenfeld | 2011 | Cell Research2011，21，12： | 4 |
| 17 | Multi-target Collaborative Combat Decision-Making by Improved Particle Swarm Optimizer显示文摘A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat. | Ding Yongfei Yang Liuqing Hou Jianyong Jin Guting Zhen Ziyang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 4 |
| 18 | A Deep Reinforcement Learning Algorithm for the Power Order Optimization Allocation of AGC in Interconnected Power Grids显示文摘The integration of distributed generations(solar power,wind power),energy storage devices,and electric vehicles,causes unpredictable disturbances in power grids.It has become a top priority to coordinate the distributed generations,loads,and energy storages in order to better facilitate the utilization of new energy.Therefore,a novel algorithm based on deep reinforcement learning,namely the deep PDWoLF-PHC(policy dynamics based win or learn fast-policy hill climbing)network(DPDPN),is proposed to allocate power order among the various generators.The proposed algorithm combines the decision mechanism of reinforcement learning with the prediction mechanism of a deep neural network to obtain the optimal coordinated control for the source-grid-load.Consequently it solves the problem brought by stochastic disturbances and improves the utilization rate of new energy.Simulations are conducted with the case of the improved IEEE two-area and a case in the Guangdong power grid.Results show that the adaptability and control performance of the power system are improved using the proposed algorithm as compared with using other existing strategies. | Lei Xi Lipeng Zhou Lang Liu Dongliang Duan Yanchun Xu Liuqing Yang Shouxiang Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 4 |
| 19 | Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-L-lysine-Assisted Magnetic Iron Oxide Nanoparticles显示文摘Cell labeling with magnetic iron oxide nanoparticles(IONPs)is increasingly a routine approach in the cellbased cancer treatment.However,cell labeling with magnetic IONPs and their leading effects on the biological properties of human lung carcinoma cells remain scarcely reported.Therefore,in the present study the magnetic c-Fe2O3nanoparticles(MNPs)were firstly synthesized and surface-modified with cationic poly-L-lysine(PLL)to construct the PLL-MNPs,which were then used to magnetically label human A549 lung cancer cells.Cell viability and proliferation were evaluated with propidium iodide/fluorescein diacetate double staining and standard 3-(4,5-dimethylthiazol-2-diphenyl-tetrazolium)bromide assay,and the cytoskeleton was immunocytochemically stained.The cell cycle of the PLL-MNPlabeled A549 lung cancer cells was analyzed using flow cytometry.Apoptotic cells were fluorescently analyzed with nuclear-specific staining after the PLL-MNP labeling.The results showed that the constructed PLL-MNPs efficiently magnetically labeled A549 lung cancer cells and that,at low concentrations,labeling did not affect cellular viability,proliferation capability,cell cycle,and apoptosis.Furthermore,the cytoskeleton in the treated cells was detected intact in comparison with the untreated counterparts.However,the results also showed that at high concentration(400 lg m L-1),the PLL-MNPs would slightly impair cell viability,proliferation,cell cycle,and apoptosis and disrupt the cytoskeleton in the treated A549 lung cancer cells.Therefore,the present results indicated that the PLL-MNPs at adequate concentrations can be efficiently used for labeling A549 lung cancer cells and could be considered as a feasible approach for magnetic targeted anti-cancer drug/gene delivery,targeted diagnosis,and therapy in lung cancer treatment. | Xueqin Wang Huiru Zhang Hongjuan Jing Liuqing Cui | 2015 | Nano-Micro Letters2015，7，4： | 4 |
| 20 | Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect显示文摘Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule-intercellular adhesion molecule-1(ICAM-1)on A20 cells and led to enhanced A20 cell apoptosis.LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon(IFN)-c production in vitro.Immunization of BALB/c mice with a LIGHT-modified A20 cell vaccine efficiently elicited protective immunity against challenge with the parental tumor cell line.Adenovirus-mediated gene transfer of LIGHT by intratumoral injection exerted a very potent antitumor effect against pre-existing A20 cell lymphoma in BALB/c mice.This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer(NK)and cytotoxic T lymphocyte(CTL)activity,enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21(CCL21),IFN-inducible protein-10(IP-10)and monokine induced by IFN-c(Mig)from tumor tissues.Thus,adenovirus-mediated LIGHT therapy might have potential utility for the prevention and treatment of B-cell lymphoma. | Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
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