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| 1 | Circulating miRNA and cancer diagnosis显示文摘miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area. | TIE Yi1, LIU BinDong2, FU HanJiang1 & ZHENG XiaoFei1· 1 Beijing Institute of Radiation Medicine, Bejing 100850, China 2 Health Disparities/HIV Immed Ofc, Meharry Medical College, Nashville TN 37208, USA | 2009 | Science China(Life Sciences)2009，52，12： | 9 |
| 2 | Micro RNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum显示文摘Micro RNA-124 contributes to neurogenesis through regulating its targets,but its expression both in the brain of Huntington's disease mouse models and patients is decreased.However,the effects of micro RNA-124 on the progression of Huntington's disease have not been reported.Results from this study showed that micro RNA-124 increased the latency to fall for each R6/2 Huntington's disease transgenic mouse in the rotarod test.5-Bromo-2'-deoxyuridine(Brd U) staining of the striatum shows an increase in neurogenesis.In addition,brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased.These findings suggest that micro RNA-124 slows down the progression of Huntington's disease possibly through its important role in neuronal differentiation and survival. | Tian Liu Wooseok Im Inhee Mook-Jung Manho Kim | 2015 | Neural Regeneration Research2015，10，5： | 8 |
| 3 | Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis显示文摘OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway. | QI Qin Hyoyoung Im LI Kunshan GU Muen WU Huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 5 |
| 4 | A highly sensitive chemical gas detecting transistor based on highly crystalline CVD-grown MoSe2 films显示文摘有原子厚度的分层的半导体由于他们的高级搬运人活动性,大 surface-to-volume 比率,和对他们的包围环境的快速的电的回答在高效的电子设备作为活跃元素正在变得日益重要。这里,我们报导高度敏感的 chemical-vapor-deposition-grown 的第一实现多层的 MoSe 2 地效果晶体管(联邦货物税) 在一没有 2 气体传感器。这个传感器展出了超离频敏感(S = ca。1,907 为在 300 ppm 的没有 2) ,即时反应,并且快速的开关切换。我们的 MoSe 2 气体传感器的高敏感在 2 气体专心于在离开状态政体在洞电流导致重要增加的 MoSe 2, 的 NO 劝诱的原子价乐队附近处于差距状态被归因于变化。设备建模和量运输模拟表明没有 2 集中的差距状态的变化是在 MoSe 2 的关键机制基于联邦货物税没有 2 气体传感器。这全面研究,它探讨材料生长,设备制造,描述,和设备模拟,不是仅仅为高效的化学传感器显示 MoSe 2 联邦货物税的用途,而且建立怎么出现理解化学的一个基础在分层的半导体设备影响搬运人运输。 | Jongyeol Baek Demin Yin Na Liu Inturu Omkaram Chulseung Jung Healin Im Seongin Hong Seung Min Kim Young Ki Hong Jaehyun Hur Youngki Yoon Sunkook Kim | 2017 | Nano Research2017，10，6： | 4 |
| 5 | Distributed Virtual Inertia Based Control of Multiple Photovoltaic Systems in Autonomous Microgrid显示文摘The large inertia of a traditional power system slows down system's frequency response but also allows decent time for controlling the system.Since an autonomous renewable microgrid usually has much smaller inertia,the control system must be very fast and accurate to fight against the small inertia and uncertainties.To reduce the demanding requirements on control,this paper proposes to increase the inertia of photovoltaic(PV) system through inertia emulation.The inertia emulation is realized by controlling the charging/discharging of the direct current(DC)-link capacitor over a certain range and adjusting the PV generation when it is feasible and/or necessary.By well designing the inertia,the DC-link capacitor parameters and the control range,the negative impact of inertia emulation on energy efficiency can be reduced.The proposed algorithm can be integrated with distributed generation setting algorithms to improve dynamic performance and lower implementation requirements.Simulation studies demonstrate the effectiveness of the proposed solution. | Won-Sang Im Cheng Wang Wenxin Liu Liming Liu Jang-Mok Kim | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 3 |
| 6 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 7 | Extract of Ginkgo biloba induces phase 2 genes through Keapl-Nrf2-ARE signaling pathway显示文摘 | LIU XP GOLDRING CE COPPLE IM | 2007 | Life Sci2007，80，17： | 1 |
| 8 | Posterior capsule opacification显示文摘 | Wormstone IM Wang L Liu CS | 2009 | Exp Eye Res2009，88，2： | 1 |
| 9 | Factorial designs combined with the steepest ascent method to optimize serum-flee media for CHO cells 显示文摘 | Liu CH Chu IM Hwang SM | 2011 | Enzy Microbial Tech2011，28，45： | 1 |
| 10 | Changes of superox ide dismutase gene expression and activity in the brain of streptozotocin-induced diabetic rats 显示文摘 | Huang WC Juang SW Liu IM | 1999 | Neurosci Lett1999，275，1： | 1 |
| 11 | The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA- uPAR complex and inhibiting its signaling and internalization 显示文摘 | Liu Y Cao DJ Sainz IM | 2008 | Am J Physiol Cell Physiol2008，295，1： | 1 |
| 12 | Ectopic recurrence of craniopharyngioma after an interhemispheric transcallosal approacha:case report显示文摘 | Liu JM Garonzik IM Eberhart CG | 2002 | Neurosurgery2002，50，3： | 1 |
| 13 | Factorial designs combined with the steepest ascent method to optimize serum-free media for ex vivo expansion of human hematopoietic progenitor cells 显示文摘 | Yao CL Liu CH Chu IM | 2003 | Enzyme Microb Tech2003，33，： | 1 |
| 14 | Posterior capsule opacification显示文摘 | Wormstone IM Wang L Liu CS | 2009 | Exp Eye Res2009，88，2： | 1 |
| 15 | Mediation of β-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats显示文摘 | Tu YK Liu IM Chen PF Cheng JT | 2006 | Planta Med2006，72，： | 1 |
| 16 | Novel mechanism for plasma glucose - lowering action of metformin in strep- tozotocin - induced diabetic rats 显示文摘 | Cheng JT Huang CC Liu IM | 2006 | Diabetes2006，55，3： | 1 |
| 17 | The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization显示文摘 | Liu Y Cao D J Sainz IM | 2008 | Am J Physiol Cell Physiol2008，295，1： | 1 |
| 18 | Mediation of beta-endorpbin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats显示文摘 | Liu IM Liou SS Cbeng JT | 2006 | J Ethnopharmacol2006，104，12： | 1 |
| 19 | Transcriptional regulatory cascades in Runx2-dependent bone development显示文摘 | Liu IM Lee EH | | 0，，： | 1 |
| 20 | In vitro development of preimplantation porcine nuclear transfer embryos cultured in different media and gas atmospheres显示文摘 | Im G S Lai L Liu Z | 2004 | Theriogenology2004，61，： | 1 |
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