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| 1 | Hemostasis in liver disease: Implications of new concepts for peri-operative management显示文摘 | Pepijn D. Weeder Robert J. Porte Ton Lisman | 2014 | Transfusion Medicine Reviews2014，，： | 2 |
| 2 | Elevated Plasma Tissue-type Plasminogen Activator (t-PA) and Soluble Throm-bomodulin in Patients Suffering From Severe Acute Respiratory Syndrome (SARS) as a Possible Index for Prognosis and Treatment Strategy显示文摘Objective To detect the presence of endothelial injury in patients with severe acute respiratory syndrome (SARS) via enhanced levels of tissue-type plasminogen activator (t-PA) and soluble thrombomodulin (sTM). Methods Case patients were from Xuanwu Hospital (Capital University of Medical Sciences, Beijing, China), and all of them met clinical criteria for SARS. Healthy controls were some of the hospital employees. Endothelial injury bio-markers tPA and sTM were detected by commercial ELISA-methods. Results Classic plasma markers of endothelial injury, tPA and sTM significantly elevated in SARS patients in comparison to controls [t-PA: 1.48±0.16 nmol/L versus 0.25±0.03 nmol/L (P<0.0001), and sTM: 0.26±0.06 nmol/L versus 0.14±0.02 nmol/L (P<0.05)]. The only patient who died had extremely high levels of these endothelial injury markers (t-PA: 2.77 nmol/L and sTM: 1.01 nmol/L). The likelihood ratio analysis indicated the excellent discriminating power for SARS at the optimal cut-point of 0.49 nmol/L for tPA and 0.20 nmol/L for sTM, respectively. Significant numerical correlations were found among these endothelial injury markers in SARS patients. The numerical coefficient of correlation Pearson r between t-PA and sTM was 0.5867 (P<0.05). Conclusion Increased plasma concentrations of tPA and sTM in patients with SARS suggest the possibility of endothelial injury. SARS patients might need anticoagulant therapy or fibrinolytic therapy in order to reverse intraalveolar coagulation, microthrombi formation, alveolar and interstitial fibrin deposition. It may not only provide a useful treatment and prognostic index but also allow a further understanding of the pathological condition of the disease. | ZHONG-HUA LIU RAN WEI YA-PING WU TON LISMAN ZENG-XIAN WANG JI-JU HAN DAO-LING REN BIN CHEN ZUO-LI XIA BIAO CHEN ZHEN ZHU YAN ZHANG XING CUI HAI-TAO HU PHILIP G. DE GROOT WEN-BO XU | 2005 | Biomedical and Environmental Sciences2005，18，4： | 2 |
| 3 | Rebalanced hemostasis in patients with liver disease:evidence and clinical consequences显示文摘 | Lisman T Porte RJ | 2010 | Blood2010，116，6： | 1 |
| 4 | Inflammation mediated Downrgulation of hepatobiliary transporters contributes to intrahepatic cholestasis and liver damasge in murine biliary atresia显示文摘 | Yang H Plosch T Lisman T | | 0，，04： | 1 |
| 5 | Is chronic liver disease associated with a bleeding diathesis 显示文摘 | Lisman T Caldwell SH Leebeek FW | 2006 | J Thromb Haemost2006，4，9： | 1 |
| 6 | Bursts as a unit of neural information;making unreliable synapses reliable显示文摘 | Lisman JE | 1997 | Trends Neurosci1997，20，： | 1 |
| 7 | Volkmann's contractwre of the extraocular muscles following blowout fracture显示文摘 | Smith B Lisman RD Simonton J | 1984 | Plast Reconstr Surg1984，74，2： | 1 |
| 8 | Diplopia af- ter surgical repair of orbital floor fractures 显示文摘 | Biesman BS Homblass A Lisman R | 1996 | Ophthal Plast Reconstr Surg1996，12，： | 1 |
| 9 | Diplopia after surgical repair of orbital floor fractures 显示文摘 | Biesman BS Homblass A Lisman R | 1996 | Ophthal Plast Reconstr Surg1996，12，1： | 1 |
| 10 | Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI l显示文摘 | Meltzer ME Lisman T de Groot PG | 2010 | Blood2010，116，1： | 1 |
| 11 | Synaptic plasticity:A molecular memory switch 显示文摘 | Lisman JE Mclntyre CC | 2001 | Curr Biol2001，11，19： | 1 |
| 12 | How to mini- mize blood loss during liver surgery in patients with cirrhosis 显示文摘 | Westerkamp AC Lisman T Porte RJ | 2009 | HPB2009，11，6： | 1 |
| 13 | Platelet Transfusion During Liver Transplantation Is Associated with Increased Postoperative Mortality Due to Acute Lung Injury显示文摘 | Ilona T. A. Pereboom Marieke T. de Boer Elizabeth B. Haagsma Herman G. D. Hendriks Ton Lisman Robert J. Porte | 2009 | Anesthesia & Analgesia2009，，4： | 1 |
| 14 | NMDA receptor-mediated subthreshold Ca(2 +) signals in spines of hippocampal neurons显示文摘 | Kovalchuk Y Eilers J Lisman J | | 0，，05： | 1 |
| 15 | The molecular basis of CaMKII function in synaptic and behavioral memory显示文摘 | Lisman J Schulman H Cline H | 2002 | Nat Rev Neurosci2002，3，3： | 1 |
| 16 | Functional Move- ment Screen and Aerobic Fitness Predict Injuries in Military Training显示文摘 | Lisman P O Connor FG Deuster PA | 2013 | Med Sci Sports Exerc2013，45，4： | 1 |
| 17 | The molecular basis of CaMKII function in synaptic and behavioural memory显示文摘 | Lisman J Schulman H Cline H | 2002 | Nat Rev Neurosci2002，3，3： | 1 |
| 18 | A mechanism for the Hebb and ant-Hebb processes underlying leafing and memory显示文摘 | Lisman J | 1989 | Proc Nail Acad Scl USA1989，86，： | 1 |
| 19 | Prospective evaluation of coagulopathy in multiple myeloma patients before, during and Clin Exp Med 123 after various chemotherapeutic regimens 显示文摘 | van Marion AM Auwerda JJ Lisman T et o2 | 2008 | Leuk Res2008，32，7： | 1 |
| 20 | A labile component of AMPA receptor-mediated synaptic transmissi-on is dependent on microtubule motors, actin, and N-ethy/maleimide-sensitive factor 显示文摘 | Kim CH Lisman JE | 2001 | Neurosci2001，21，12： | 1 |
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