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| 1 | Microvascular decompression in patients with hemifacial spasm: report of 1200 cases显示文摘Background Microvascular Decompression (MVD) operation is the most reliable treatment for hemifacial spasm (HFS), but it causes many complications. The aim of this retrospective study was to investigate the factors relavent to the effects and postoperative complications of microvascular decompression on hemifacial spasm. Methods A total of 1200 HFS patients treated with MVD were studied retrospectively. The root exit zone (REZ) of the facial nerve was exposed through the infraflocculus approach, the offending vessels were identified and separated from the REZ, and a Teflon graft was interposed between the offending vessels and the brain stem. Brain stem auditory evoked potential (AEP) was monitored intraoperatively. Results The offending vessels can be identified in all patients. The anteroinferior cerebellar artery was the main offending vessel (42.6%). Patients with vertebral artery compression had a multiple vascular compression fashion. Follow-up for 2-10 years (mean 4.2 years) showed that 88.7% patients were cured and 5.6% relieved, with an effective rate of 94.3%. Recurrence rate was 3.2%, and the ineffective rate was 2.6%. The most frequent complication was hearing dysfunction (2.8%). Conclusions MVD is the most definitive treatment method of HFS. The key procedures of this operation include adequate exposure of the REZ, identification of the offending vessels, and proper positioning of Teflon grafts. Complications can be reduced effectively by utilizing a real-time AEP monitoring during the operation. | YUANYue WANGYan ZHANGSi-xun ZHANGLi LIRui GUOJing | 2005 | Chinese Medical Journal2005，，10： | 36 |
| 2 | Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy显示文摘Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future. | Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui | 2019 | Cancer Biology & Medicine2019，16，4： | 7 |
| 3 | Solid-phase Crystallization of Amorphous Silicon Films by Rapid Thermal Annealing显示文摘The morphous silicon films prepared by PECVD at substrate temperatures of 30℃ have been crystallized by rapid thermal annealing method, the budget of time-temperature in the annealing process is 600℃ for 120s, 850℃ for 120s, and 950℃ for 120s. The results indicate the crystallization at 850℃ and 950℃ are better as shown in micro-Raman scattering and scanning electronic microscope. | JINRui-min LUJing-xiao LIRui WANGHai-yan FENGTuan-hui | 2005 | Semiconductor Photonics and Technology2005，11，1： | 5 |
| 4 | Identification of stably expressed QTL for resistance to black shank disease in tobacco(Nicotiana tabacum L.) line Beinhart 1000-1显示文摘Cigar line Beinhart 1000-1 has effective durable resistance to black shank(BS) and is considered one of the most resistant sources in tobacco(Nicotiana tabacum L.). To investigate the inheritance and identification of stable quantitative trait loci(QTL) for BS response, F2,BC1 F2 individuals and BC1 F2:3 lines were produced from a cross between Beinhart 1000-1 and Xiaohuangjin 1025. Two major quantitative trait loci(M-QTL) named qBS7 and qBS17 were repeatedly detected under different conditions. QTL qBS7 was mapped to the region between PT30174 and PT60621 and explained 17.40%–25.60% of the phenotypic variance under different conditions. The other QTL qBS17 in interval PT61564–PT61538 of linkage group 17 was detected in a BC1 F2 population in the field and in BC1 F2:3 in both the field and at the seedling stage, explaining 6.90% to 11.60% of the phenotypic variance. The results improve our understanding of the inheritance of resistance to BS and provide information that can be used in marker-assisted breeding. | Yusheng Zhang Xuan Guo Xingxing Yan Min Ren Caihong Jiang Yazeng Cheng Liuying Wen Dan Liu Yu Zhang Mingming Sun Quanfu Feng Aiguo Yang Lirui Cheng | 2018 | The Crop Journal2018，6，3： | 4 |
| 5 | Microbial transformation of lovastatin by Beauveria bassiana显示文摘Microbial transformation of lovastatin(1)by resting cells of a filamentous fungus,Beauveria bassiana AS 3.4270,yielded five metabolites(2-6),which were unambiguously characterized by various spectroscopic data analyses.The occurred reactions included hydroxyla-tion,lactone hydrolysis and methylation.The inhibitory effects of all metabolites on the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase were evaluated.Of the five compounds,4 ex hibited comparable inhibitory effect to lovastatin on the HMG-CoA reductase with ICso value of 2.2μM,and inhibitory rate of 81.4%. | Lirui Qiao Dan Xie Quan Liu Jianhua Zou Zhufang Shen Jungui Dai | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 4 |
| 6 | High-density SNP genetic linkage map construction and quantitative trait locus mapping for resistance to cucumber mosaic virus in tobacco(Nicotiana tabacum L.)显示文摘Genetic linkage maps are essential for studies of genetics, genomic structure, and genomic evolution, and for mapping quantitative trait loci (QTL). Identification of molecular markers and construction of genetic linkage maps in tobacco (Nicotiana tabacum L.), a classical model plant and important economic crop, have remained limited. In the present study we identified a large number of single nucleotide polymorphism (SNP) markers and constructed a high-density SNP genetic map for tobacco using restriction site-associated DNA sequencing. In 1216.30 Gb of clean sequence obtained using the Illumina HiSeq 2000 sequencing platform, 99,647,735 SNPs were identified that differed between 203 sequenced plant genomes and the tobacco reference genome. Finally, 13,273 SNP markers were mapped on 24 high-density tobacco genetic linkage groups. The entire linkage map spanned 3421.80 cM, with a mean distance of 0.26 cM between adjacent markers. Compared with genetic linkage maps published previously, this version represents a considerable improvement in the number and density of markers. Seven QTL for resistance to cucumber mosaic virus (CMV) in tobacco were mapped to groups 5 and 8. This high-density genetic map is a promising tool for elucidation of the genetic bases of QTL and for molecular breeding in tobacco. | Lirui Cheng Xiaocui Chen Caihong Jiang Bing Ma Min Ren Yazeng Cheng Dan Liu Ruimei Geng Aiguo Yang | 2019 | The Crop Journal2019，7，4： | 3 |
| 7 | ADSORPTION OF LDL ON THE MODIFIED CHITOSAN显示文摘In this paper, the selective adsorption of LDL on chitosan modified with PEG and Asp. was studied. The adsorption rate of LDL and HDL on the double modified chitosan was 57% and 12% respectively. The results shown that the double modified chitosan can be used a adsorbent for selective binding to LDL. This work may help to develop functional columns for hemoperfusion. | LIU Manying ZHAO Lirui TAI Liwen JI Xueping YANG Chunxia WANG Aiping | 2000 | Chinese Journal of Reactive Polymers2000，9，2： | 3 |
| 8 | Clinical significance of extended high-risk human papillomavirus genotyping and viral load in cervical cancer and precancerous lesions显示文摘Persistent infections with specific high-risk human papillomavirus(HR-HPV)strains are the leading cause of cervical cancer and precancerous lesions.HPV-16 and HPV-18 are associated with more than 70%of cervical cancer.However,with recent widespread vaccination efforts against cervical cancer,the infection rates of HPV-16 and HPV-18 have decreased across all age groups,while the infection rates of other HR-HPV strains have increased.The non-16/18 HR-HPV strains play an important role in cervical lesions.These strains can be identified with extended genotyping,and the 2019 American Society for Colposcopy and Cervical Pathology(ASCCP)guidelines recommended an HPV-based testing to assess the risk of cervical disease in patients.We reviewed and analyzed the clinical benefits of applying extended HR-HPV genotyping,which was published by the International Agency for Research on Cancer(HPV-16,18,31,33,35,39,45,51,52,56,58,59,66,and 68),to cervical cancer screening.This review concluded that cervical cancer screening needs to include extended HR-HPV genotyping.The examination of extended HR-HPV genotyping in cervical intraepithelial lesions and cervical cancers can help guide clinical practices. | Pingping Su Jincheng Ma Lirui Yu Shuting Tang Pengming Sun | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 2 |
| 9 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 10 | Studies on the Programmed Cell Death in Rice During Starchy Endosperm Development显示文摘Morphological variations of the nucleus in starchy endosperm cell were observed by theelectron-transmisson microscope during endosperm development in rice. Along with thedevelopment of the starchy endosperm, the nuclei of the cells showed chromatin condensation,the typical feature of programmed cell death (PCD). The nuclei also showed nucleusdeformation, disruption of nuclear envelope, nucleoplasm leaking into the cytoplasm andnucleus disintegration resulting in nuclear residue formation. From the nucleus deformationto the nucleus disintegration, the morphological changes of the nucleus were orderlyprogressive. This indicated that the cell death of starchy endosperm in rice wasprogrammed cell death. Evans Blue staining observation showed that the cell death wasinitially detected in the central part of starchy endosperm in rice, then expandedoutward. The activities of superoxide dismutase (SOD) and catalase (CAT) in rice starchyendosperm both descended continuously as development progressed. The analysis of DNA ofrice starchy endosperm did not show the presence of DNA laddering. The above resultsshowed that the cell death of starchy endosperm in rice was a special form of PCD. | LIRui LANSheng-yin XUZhen-xiu | 2004 | Agricultural Sciences in China2004，3，9： | 2 |
| 11 | Comparative transcriptome analysis reveals differential gene expression in resistant and susceptible tobacco cultivars in response to infection by cucumber mosaic virus显示文摘Cucumber mosaic virus(CMV) is one of the most severe viral diseases transmitted by aphids infecting Solanum crops in China, causing great losses of crop yields and income in rural communities.The tobacco cultivars NC82 and Taiyan 8 are closely related but differ in resistance to CMV.NC82 is susceptible to infection and Taiyan 8 is resistant, but the mechanisms underlying this difference in resistance are not clear.In this study, we conducted RNA sequencing to analyze changes in gene expression induced in the leaves of Taiyan 8 and NC82 upon systemic infection with CMV, compared with gene expression in the leaves of mock-inoculated plants.Leaves were sampled at one, three, eight, and 15 days after infection.In total, 3443 and 747 differentially expressed genes were identified in Taiyan 8 and NC82, respectively.Gene ontology and pathway enrichment analyses revealed that the different responses to CMV infection between cultivars were based on microtubulebased processes, pentose and glucuronate interconversions, plant–pathogen interaction,and hormone signal transduction pathways.Genes encoding pathogenesis-related proteins, disease-resistance proteins, lipoxygenase, cellulose synthase, an auxin response factor, and an ethylene receptor showed different expression patterns.The differences in gene expression following CMV infection likely contributed to the different resistance levels of these two tobacco cultivars.The comprehensive transcriptome dataset described here,which includes candidate response genes, will serve as a resource for further studies of the molecular mechanisms associated with tobacco defense responses against CMV. | Dan Liu Yazeng Cheng Min Gong Qiang Zhao Caihong Jiang Lirui Cheng Min Ren Yuanying Wang Aiguo Yang | 2019 | The Crop Journal2019，7，3： | 2 |
| 12 | Factors affecting thermal stability of collagen from the aspects of extraction,processing and modification显示文摘Collagen,as a thermal-sensitive protein,is the most abundant structural protein in animals.Native collagen has been widely applied in various fields due to its specific physicochemical and biological properties.The beneficial properties would disappear with the collapse of the unique triple helical structure during heating.Understanding thermal stability of collagen is of great significance for practical applications.Previous studies have shown the thermal stability would be affected by the different sources,extraction methods,solvent systems in vitro and modified methods.Accordingly,the factors affecting thermal stability of collagen are discussed in detail in this review. | Xiaoxia Zhang Songcheng Xu Lirui Shen Guoying Li | 2020 | Journal of Leather Science and Engineering2020，2，1： | 2 |
| 13 | Effects of Different Dietary Energy and Protein Levels on Meat Performance and Meat Quality of Jinghai Yellow Chickens显示文摘To investigate the effect of different dietary energy and protein levels on meat performance and meat quality of Jinghai yellow chickens,480 43-day old Jinghai yellow chickens with similar weight were randomly divided into four experimental groups: experimental group 1( protein 15%,metabolic energy 9. 95 MJ /kg),experimental group 2( protein 16%,metabolic energy 10. 95 MJ /kg),experimental group 3( protein 17%,metabolic energy 12. 65 MJ /kg) and experimental group 4( protein 18%,metabolic energy 13. 95 MJ /kg),respectively. All chickens were slaughtered at 112-day old. The breast and leg muscles of Jinghai yellow chickens were collected,to determine the slaughter performance,conventional meat quality and muscle chemical indicators. The results indicated that dressing-out percentage and eviscerated yield percentage in four experimental groups were above 87. 27% and 67. 00%,respectively; other slaughter performance indicators exhibited no significant differences among various groups( P > 0. 05); breast muscle color of hens in experimental group 4 varied significantly from that in other three groups( P < 0. 05); leg muscle color of hens in experimental group 2 varied extremely significantly from that in other three groups( P < 0. 01); water-holding capacity of breast muscles of hens in experimental group 3 was significantly higher than that in experimental group 4( P < 0. 05); thiamine content of breast muscles of cocks in experimental group 3 was significantly higher than that in experimental group 2( P < 0. 05); however,other properties exhibited no significant differences among various groups( P > 0. 05). | Jianfeng WANG Lulu CUI Kaizhou XIE Yingying SUN Lirui SUN Jianyu LIU Genxi ZHANG Guojun DAI Jinyu WANG | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 14 | 显示文摘 | LIRui(李锐) RENHai-ping(任海平) SUNYan-ting(孙艳亭) YAOYing-yan(姚英艳) LUKui(卢奎) MALi(马丽) | 2006 | 分析化学2006，34，： | 1 |
| 15 | 显示文摘 | LIJia-jia LIRui MAXue etal(李佳佳 李睿 马雪 等) | 2016 | 光谱学与光谱分析2016，36，2： | 1 |
| 16 | Microbial transformation of gin- senoside-Rgl by Absidia coerulea and the reversal activity of the metabolites towards multi-drug resistant tumor cells显示文摘 | Liu Xin Qiao Lirui Xie Dan | 2011 | Fi- toterapia2011，，82： | 1 |
| 17 | The Brief Introduction to the Sino-US Joint Centers for Soil and Water Conservation and Environmental Protection显示文摘Erosion and transport of soil has worldwide implications for agriculture, landscape stability, climate, natural hazards, and clean, renewable resources of water and air. Assured access to clean water and a healthy and safe environment requires an ethic of conservation and protection. The minimum scale in which these principles apply successfully is basin wide. These are the fundamental concerns of the Sino-US Centers for Soil and Water Conservation and Environmental Protection. | LIJing LIRui ZHENGFen-li | 2004 | 水土保持研究2004，11，4： | 1 |
| 18 | 显示文摘 | LIUZhong-quan(刘忠全) LIRui(李锐) WULong-min(吴隆民) | 2004 | 有机化学2004，24，2： | 1 |
| 19 | Moment Analysis of a Rice-Pile Model显示文摘Large scale simulations of a rice-pile model are performed. We use moment analysis techniques to evaluate critical exponents and data collapse method to verify the obtained results. The moment analysis yields well-defined avalanche exponents, which show that the rice-pile model can be coherently described within a finite size scaling framework. The general picture resulting from our analysis allows us to characterize the large scale behavior of the present model with great accuracy. | ZHANGDuan-Ming UNHong-Zhang PANGui-Jun YUBo-Ming YINYan-Ping SUNFan LIRui SUXiang-Ying | 2005 | Communications in Theoretical Physics2005，43，3： | 1 |
| 20 | Convergent projective non-negative matrix factorization with Kullback-Leibler divergence显示文摘 | HU Lirui DAI Liang WU Jianguo | 2014 | Pattern Recognition Letters2014，，36： | 1 |
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