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| 1 | The co-administrating of recombinant porcine IL-2 could enhance protective immune responses to PRV inactivated vaccine in pigs 显示文摘 | LINY HE Q YUX | 2005 | Vaccine2005，23，： | 1 |
| 2 | Interface junction at anatase/rutile in mixed-phase TiO2 :Formation and pho- to-generated charge carriers properties 显示文摘 | Zhang X R LinY H He D Q | 2011 | Chem Phys Lett2011，504，： | 1 |
| 3 | Copper-Catalyzed Aerobic Oxidative Cleavage of Unstrained Carbon-Carbon Bonds of 1,1-Disubstituted Alkenes with Sulfonyl Hydrazides显示文摘Main observation and conclusion Alkoxy radical-mediated carbon-carbon bond cleavages have emerged as a powerful strategy to complement traditional ionic-type transformations.However,carbon-carbon cleavage reaction triggered by alkoxy radical intermediate derived from the combination of alkyl radical and dioxygen,is scarce and underdeveloped.Herein,we report alkoxy radical,which was generated from alkyl radical and dioxygen,mediated selective cleavage of unstrained carbon-carbon bond for the oxysulfonylation of 1,1-disubstituted alkenes,providing facile access to a variety of valuableβ-keto sulfones.Mechanistic experiments indicated alkoxy radical intermediate that underwent subsequent regioselectiveβ-scission might be involved in the reaction and preliminary computational studies were conducted to provide a detailed explanation on the regioselectivity of the C-C bond cleavage.Notably,the strategy was successfully applied for constructing uneasily obtained architecturally intriguing molecules. | Dong Yi Linying He Zhongyu Qi Zhijie Zhang Mengshun Li Ji Lu Jun Wei Xi Du Qiang Fu Siping Wei | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
| 4 | Observe Chinese Culture from Chinese Idioms显示文摘 | Linying He Junhong Ma Yanmin Wang | 2015 | International English Education Research2015，，11： | 0 |
| 5 | Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge.and Carthamus tinctorius L.显示文摘Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and subsequent experimental validation.Methods:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of s.miltiorrhiza and C.tinctorius as herb pair.Molecular docking was used to verify the binding of the components of these herbs and their potential targets.An H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination index.Western blot was performed to detect the protein expression of these targets.Results:Network pharmacology analysis revealed 5 pathways and 8 core targets of s.miltiorrhiza and C.tinctorius in myocardial protection.Five of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling pathway.S.miltiorrhiza-C.tinctorius achieved vascular tone mainly by regulating the target genes of the HIF-1 pathway.As an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective activity.Molecular docking verified the strong binding of Myric,Sal.B,and Ctan to STAT3.Western blot further showed that the active ingredients synergistically upregulated the protein expressionof STAT3.Conclusion:The pharmacodynamic transmission analysis revealed that the active ingredients of S.miltiorrhiza and C.tinctorius can synergistically resist ischemia through various targets and pathways.This study provides a methodological reference for interpreting traditional Chinese medicine compatibility. | Linying Zhong Ling Dong Jing Sun Jie Yang Zhiying Yu Ping He Bo Zhu Yuxin Zhu Siyuan Li Wenjuan Xu | 2024 | Journal of Traditional Chinese Medical Sciences2024，11，1： | 0 |
| 6 | The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in rice显示文摘The growth-promoting hormones brassinosteroids(BRs)and their key signaling component BZR1 play a vital role in balancing normal growth and defense reactions.Here,we discovered that BRs and OsBZR1 up-regulated sakuranetin accumulation and conferred basal defense against Magnaporthe oryzae infection under normal conditions.Resource shortages,including phosphate(Pi)deficiency,potentially disrupt this growth-defense balance.OsSPX1 and OsSPX2 have been reported to sense Pi concentration and interact with the Pi signal mediator OsPHR2,thus regulating Pi starvation responses.In this study,we discovered that OsSPX1/2 interacts with OsBZR1 in both Pi-sufficient and Pi-deficient conditions,inhibit-ing BR-responsive genes.When Pi is sufficient,OsSPX1/2 is captured by OsPHR2,enabling most of OsBzR1 to promote plant growth and maintain basal resistance.In response to Pi starvation,more OsSPX1/2 is released from OsPHR2 to inhibit OsBZR1 activity,resulting in slower growth.Collectively,our study reveals that the OsBZR1-SPX1/2 module balances the plant growth-immunity trade-off in responsetoPiavailability.He Y.,Zhao Y.,Hu J.,Wang L.,Li L.,Zhang X.,Zhou Z.,Chen L.,Wang H.,Wang J.,and Hong G.(2024).The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in esponse to Pi availability. | Yuqing He Yao Zhao Jitao Hu Lanlan Wang Linying Li Xueying Zhang Zhongjing Zhou Lili Chen Hua Wangl Jiaoyu Wang Gaojie Hong | 2024 | Molecular Plant2024，17，2： | 0 |
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