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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | Orthotopic liver transplantation for fulminant hepatitis B显示文摘INTRODUCTION When fulminant hepatitis progress to deep encephalopathy,with stage Ⅲ or Ⅳ coma,it is commonly irreversible with a high mortality rate(80%-100%).Liver transplantation may be | He XS Huang JF Chen GH Fu Q Zhu XF Lu MQ Wang GD Guan XD | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 4 | Twist基因蛋白表达在甲状腺乳头状癌诊断与鉴别诊断中的意义显示文摘目的探讨Twist基因蛋白在甲状腺乳头状癌中的表达状况,寻找更特异的标记物,用于甲状腺乳头状癌(PTC)与滤泡状腺瘤(FA)和良性乳头病变(BPL)的鉴别诊断。方法以50例PTC为研究组,以48例FA和47例BPL作对照组。在自制组织芯片上行免疫组织化学(SP法)标记,检测Twist基因蛋白和HBME-1,并以CK19进行对照。结果3种指标(Twist、HBME-1、CK19)阳性表达率:在PTC组分别为100%(48/48)、94.0%(47/50)和78.0%(39/50);在FA组分别为0、6.7%(3/45)和0;在BPL组分别为7.0%(3/43)、2.1%(1/47)和0。PTC组分别与FA和BPL组比较差异均有统计学意义(P=0.000)。3种指标在鉴别诊断甲状腺良、恶性病变的灵敏度分别为:100%、96.4%和97.7%,特异度分别为:94.0%、95.7%和95.1%,准确度分别为:78.0%、100%和91.9%。结论Twist可应用于辅助诊断PTC,并可应用在对FA或BPL的鉴别诊断。 | 何春年 Lili He Jin Q Cheng 陈士超 赵焕芬 翟金萍 张静 | 2008 | 中华病理学杂志2008，37，1： | 14 |
| 5 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 6 | Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture显示文摘α-smooth muscle actin(α-SMA) and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament(PDL) under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1(TGF-β1) and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells(h PDLCs). The h PDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading. | Hui Xu Ding Bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han | 2015 | International Journal of Oral Science2015，7，4： | 5 |
| 7 | The signaling adaptors and pathways activated by TNF superfamily显示文摘 | Paul W Dempsey Sean E Doyle Jeannie Q He Genhong Cheng | 2003 | Cytokine and Growth Factor Reviews2003，，3： | 2 |
| 8 | Disruption of sphingolipid homeostasis by myrioein, a myeotoxin, reduces thymie and splenic T-lymphocyte populations显示文摘 | Johnson V J He Q Osuchowski M F | 2004 | Toxicology2004，201，13： | 1 |
| 9 | High mobility group box I protein interacts with multiple Toll-like receptors 显示文摘 | Park JS Gamboni-Robertson F He Q | 2006 | Am J Physiol Cell Physiol2006，290，3： | 1 |
| 10 | An effective co-evolutionary particle swarm optimization for constrained engineering design problems显示文摘 | He Q Wang L | 2007 | Engineering Applications of Artificial Intelligence2007，20，1： | 1 |
| 11 | disturbance attenuation for state delayed systems 显示文摘 | Wang Q G Lee T H | 1998 | System & Control Letters1998，33，： | 1 |
| 12 | Cyanea capillata tentacle-only extract as a potential alternative of nematocyst venom:its cardiovascular toxicity and tolerance to isolation and purification procedures显示文摘 | Xiao L He Q Guo Y | 2009 | Toxicon2009，53，1： | 1 |
| 13 | Delay-range-dependent stability for systems with time-varying delay显示文摘 | He Y Wang Q G Lin C | 2007 | Automatica2007，43，： | 1 |
| 14 | Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose,tissue显示文摘 | Yin J Gao Z He Q | 2009 | Am J Physiol Endocrinol Metab2009，296，2： | 1 |
| 15 | Aquaporin-2 expression in human endometrium con'elates with serum ovarian steroid hormones显示文摘 | He RH Sheng JZ Luo Q | 2006 | Life Sci2006，79，： | 1 |
| 16 | SmBaCo2O5+δdouble-perovs- kite structure cathode material for intermediate temperature solid oxide fuel cells显示文摘 | Zhou Q He T He Q | 2008 | J Power Sources2008，185，： | 1 |
| 17 | Differential profile of genes expressed in hemocytes ofwhite spot syndrome virus-resistant shrimp(Penaeus japonicus)by combi-ning suppression subtractive hybridization and differential hybridization显示文摘 | HE N QIN Q XU X | 2005 | Antiviral Res2005，66，1： | 1 |
| 18 | Concentration of thymidinekinase l in serum(S-TKI)is a more sensitive proliferationmaker in human solid tumors than its activity显示文摘 | He Q Zou L Zhang PA | 2005 | Oncol Rep2005，14，4： | 1 |
| 19 | An alternative paclitaxel microemulsion formulation:hypersensitivity evaluation and pharmacokinetic profile显示文摘 | He L Wang GL Zhang Q | 2003 | Int J Pharm2003，250，1： | 1 |
| 20 | Stages of rock bream Oplegnathus fasciatus (Temminck et Schlegel 1844): embryonic development显示文摘 | He T Xiao Z Z Liu Q H | 2011 | Aquaculture Research2011，42，12： | 1 |
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