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| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Recent progress of efficient utilization of titanium-bearing blast furnace slag显示文摘Titanium-bearing blast furnace slag(BFS)has valuable compositions and potential environmental hazardousness.Thus,developing efficient and green approaches to utilize BFS is highly desired for resource economization and environmental protection.In the past decades,many attempts have been adopted to reuse BFS efficiently,and significant advances in understanding the fundamental features and the development of efficient approaches have been achieved.This review provides a comprehensive overview of the latest progress on the efficient utilization of BFS and discusses the mechanism and characteristics of various approaches,along with their application prospects.In particular,the extraction and enrichment of titanium-bearing phases from BFS are highlighted because of the high availability of titanium resources.This systemic and comprehensive review may benefit the design of new and green utilization routes with high efficiency and low cost. | Yongfeng Cai Ningning Song Yunfei Yang Lingmin Sun Peng Hu Jinshu Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 2 |
| 3 | Modification of agarose with carboxylation and grafting dopamine for promotion of its cell-adhesiveness显示文摘 | Su Yixue Chu Bin Gao Yuan Wu Chaoxi Zhang Lingmin Chen Peng Wang Xiaoying Tang Shunqing | 2013 | Carbohydrate Polymers2013，，2： | 1 |
| 4 | Preparation of Agarose Sulfate and Its Antithrombogenicity显示文摘As one of the seaweed polysaccharide, agarose has received much attention because of its biocompatibility. However, its application in biomedical field was limited with its biological inertia. Modification with some functional groups is needed to obtain agarose derivatives with biological activity and expand its applications. Consequently, agarose was sulfated with chlorosulfonic acid-pyridine with formamide as dispersing agent. The orthogonal test result showed that the optimal reaction condition was the reaction time being 4 h, the reaction temperature 65 ℃, and the ratio of chlorosulfonic acid to agarose 1-4(mL/g). Two kinds of the insoluble agarose sulfate (below 37 ℃) were synthesized with degree of substitution (DS) being 0.17 and 0.43 respectively. Infrared spectroscopy (IR) and 13C nuclear magnetic resonance (13C-NMR) spectroscopy results proved that C3-6 in agarose was sulfated. Their hydrophobic property and BSA adsorption capacity rose with increasing DS, while the adsorption of Hb was reduced. The anti-clotting properties of agarose sulfate were significantly improved, and agarose sulfate could protect red blood cells from deformation after adsorption of BSA. These findings demonstrate that the cold-water insoluble agarose sulfate has a promise for applications as heparin-like material in anticoagulation or endothelial regeneration scaffold. | 揭油平 ZHANG Lingmin CHEN Peng MAO Xuan 汤顺清 | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 0 |
| 5 | Next-generation sequencing revealed factors associated with cumulative incidence of relapse and leukemia-free survival in patients with newly diagnosed acute myeloid leukemia显示文摘BackgroundSeveral prognostic biomarkers have been validated for acute myeloid leukemia(AML),a heterogeneous hematopoietic malignancy.However,the factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in real-world patients with AML have not been well defined.MethodsThis study examined clinical and mutational data of 246 patients with newly diagnosed AML who received the traditional“3+7”regimen in PLA General Hospital from January 2008 to August 2020.Factors associated with CIR and LFS in patients newly diagnosed with AML were analyzed using next-generation sequencing.ResultsAdditional sex combs-like 1(ASXL1)and Serine/arginine-rich splicing factor 2(SRSF2)mutations were found to be associated with an increased risk of CIR and a reduced LFS in univariate analysis,while only SRSF2 mutations were associated with these factors in the multivariate analysis.Hyperleukocytosis maintained an independent effect on LFS in the multivariate analysis.Hematopoietic stem cell transplantation conferred a significant prognostic benefit on both CIR and LFS in our cohort.Furthermore,we validated the risk classification of patients with AML receiving traditional induction regimens across a broad age range.Based on next-generation sequencing results,we concluded that SRSF2 mutations were predictive of an increased risk of relapse,inferior LFS rates,and non-relapse mortality in patients with newly diagnosed AML.ConclusionThese findings indicate that patients with SRSF2 mutations might not benefit from the conventional“3+7”regimen.Our results may help in developing molecular stratification strategies and could guide treatment decisions for patients with newly diagnosed AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Mingyu Jia Jing Chen Nan Wang Fei Li Lixia Liu Jiayue Qin Chengcheng Wang Shanbo Cao Liping Dou Daihong Liu | 2023 | Cancer Pathogenesis and Therapy2023，1，1： | 0 |
| 6 | River restoration challenges with a specific view on hydromorphology显示文摘1 Introduction 1.1 River ecosystem degradation Over the past century,almost throughout the whole world,streams and rivers have been heavily polluted and morphologically degraded due to industrial,household and agricultural sources,leading to significant declines in biodiversity,water quality and ultimately water supply[1-5].In the last decades,river system design has been practiced from an engineering viewpoint that focuses on water abstraction,sanitation,generation of energy,transportation and safety,rather than from a socio-ecological perspective.The technical management altered the understanding of a functioning river system itself and its social context. | Jianhua LI Stephan HOERBINGER Clemens WEISSTEINER Lingmin PENG Hans Peter RAUCH | 2020 | Frontiers of Structural and Civil Engineering2020，14，5： | 0 |
| 7 | Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine显示文摘Background:Acute myeloid leukemia(AML)is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers.Decitabine,a deoxyribonucleic acid(DNA)methyltransferase(DNMT)in-hibitor,combined with cytarabine,aclarubicin hydrochloride,and granulocyte colony-stimulating factor(DCAG),has been used in patients newly diagnosed with AML.This regimen has been especially used in older and fragile patients who are immunocompromised or have co-morbidities,as well as those with specific gene mutations.However,the integration of molecular risk stratification and treatment guidance for the DCAG regimen has not been well defined.Therefore,this study aimed to investigate the genetic mutations associated with AML and establish appropriate treatment strategies for patients newly diagnosed with AML.Methods:This study analyzed the clinical data and genetic mutations based on next-generation sequencing(NGS)in 124 newly diagnosed patients with AML who received the DCAG regimen at the People's Liberation Army(PLA)General Hospital from January 2008 to August 2020.Factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in patients newly diagnosed with AML were analyzed.Results:The most adverse prognosis of DCAG-treated patients was observed in those with FLT3-ITD,KIT,PTPN11,GATA2,or IDH1 mutations during univariable analysis,whereas PTPN11 mutation was solely significant in multivariable analysis,with an increased likelihood of CIR(P=0.001)and reduced LFS duration(P=0.077).Hyperleukocytosis was maintained as an independent risk factor for increased CIR risk(P=0.044)and decreased LFS duration(P=0.042)in multivariable analysis.In this study,we validated the risk classification of patients with AML receiving an epigenetic modifier-based induction regimen across a broad age range.Conclusion:NGS demonstrated a dismal overall outcome in patients with the rare PTPN11 mutations,indicating the need for new therapies that target this high-risk subtype of AML.These results offer a potential molecular stratification and treatment guidance for patients with AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Nan Wang Fei Li Liping Dou Daihong Liu | 2024 | Cancer Pathogenesis and Therapy2024，2，2： | 0 |
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