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| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Phylogenetic diversity and specificity of bacteria associated with Microcystis aeruginosa and other cyanobacteria显示文摘Interactions between bacteria and cyanobacteria have been suggested to have a potential to influence harmful algal bloom dynamics; however, little information on these interactions has been reported. In this study, the bacterial communities associated with five strains of Microcystis aeruginosa, three species of other Microcystis spp., and four representative species of non-Microcystis cyanobacteria were compared. Bacterial 16S rDNA fragments were amplified and separated by denaturing gradient gel electrophoresis (DGGE) followed by DNA sequence analysis. The similarities among bacterial communities associated with these cyanobacteria were compared to the digitized DGGE profiles using the cluster analyses. The bacterial community structure of all cyanobacterial cultures differed. Cluster analysis showed that the similarity values among M. aeruginosa cultures were higher than those of other cyanobacterial cultures. Sequence analysis of DGGE fragments indicated the presence of bacteria including, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Bacteroidetes and Actinobacteria in the cyanobacterial cultures. Members of the Sphingomonadales were the prevalent group among the Microcystis-associated bacteria. The results provided further evidence for species-specific associations between cyanoabcteria and heterotrophic bacteria, which are useful for understanding interactions between Microcystis and their associated bacteria. | SHI Limei CAI Yuanfeng YANG Hualin XING Peng LI Pengfu KONG Lingdong KONG Fanxiang | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 3 | Deformation Mechanism and Vertical Sealing Capacity of Fault in the Mudstone Caprock显示文摘The petrophysical property of mudstone often transforms from ductile to brittle in the process of burial-uplift. The deformation mechanism of fault in brittle and ductile mudstone caprock is different, which leads to the formation of different types of fault zone structure. Different methods are required to evaluate the sealing mechanism of those fault zones. Based on the caprock deformation mechanism, fault sealing mechanism, quantitative evaluation method of vertical fault sealing capacity is put forward in this study. Clay smear is formed in the process of plastic deformation and its continuity controls the sealing capacity of fault. The outcrop and oil field data have confirmed that when sealing parameter SSF is less than 4–7, the clay smear becomes discontinuous and then oil and gas go through the caprock and migrate vertically. Quantities of fractures are formed in mudstone in the process of brittle deformation. The fracture density increases with the increase of the fault displacement. When the fractures are connected, oil and gas go through the caprock and migrate vertically. The connectivity of fault depends on the displacement and the thickness of caprock. On the basis of the above, a method is put forward to quantify the connectivity of fault with the juxtaposition thickness of caprock after faulting. The research on the juxtaposition thickness of caprock after faulting of the member II of Dongying Formation in Nanpu depression and the distribution of oil and gas indicates when the juxtaposition thickness of caprock is less than 96.2 m, the fault becomes leaking vertically. In the lifting stage, with the releasing and unloading of the stress, the caprock becomes brittle generally and then forms through going fault which will lead to a large quantity of oil and gas migrate vertically. | Xiaofei Fu Lingyu Yan Lingdong Meng Xiaobo Liu | 2019 | Journal of Earth Science2019，30，2： | 5 |
| 4 | Highly antifouling double network hydrogel based on poly(sulfobetaine methacrylate)and sodium alginate with great toughness显示文摘Hydrogels with good antifouling and mechanical properties as well as biocompatibility have great application potential in the field of biomedicine.In this paper,a newly double network(DN)hydrogel was prepared based on zwitterionic material sulfobetaine methacrylate(SBMA)and natural polysaccharide,sodium alginate(SA).The PSBMA network is covalently crosslinked while the SA network is ionically crosslinked by Ca^(2+).The hybrid crosslinked double network structure endows the DN hydrogel with excellent mechanical properties(E=0.19±0.01 MPa,σ=0.73±0.03 MPa),fast self-recovery ability as well as excellent fatigue resistance.Moreover,the results show that the PSBMA/SA-Ca^(2+)DN hydrogel is biocompatible and resists the absorption of non-specific proteins and adhesion of microorganisms,such as cells and algae,exhibiting outstanding antifouling properties.These unique characteristics of PSBMA/SA-Ca^(2+)DN hydrogel make it a promising candidate for biomedical application,such as artificial connective tissues,implantable devices,and underwater equipment. | Jing Zhang Sunxiang Qian Lingdong Chen Liqun Chen Liping Zhao Jie Feng | 2021 | Journal of Materials Science & Technology2021，，26： | 4 |
| 5 | Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides显示文摘Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect. | Chong Zhang Jianhua Lu Falin Tian Lindong Li Yingqin Hou Yaoyi Wang Lingdong Sun Xinghua Shi Hua Lu | 2019 | Nano Research2019，12，4： | 4 |
| 6 | Individual particle analysis of aerosols collected at Lhasa City in the Tibetan Plateau显示文摘To understand the composition and major sources of aerosol particles in Lhasa City on the Tibetan Plateau(TP), individual particles were collected from 2 February to 8 March, 2013 in Tibet University. The mean concentrations of both PM2.5and PM10 during the sampling were25.7 ± 21.7 and 57.2 ± 46.7 μg/m3, respectively, much lower than those of other cities in East and South Asia, but higher than those in the remote region in TP like Nam Co, indicating minor urban pollution. Combining the observations with the meteorological parameters and back trajectory analysis, it was concluded that local sources controlled the pollution during the sampling. Transmission electron microscopy(TEM) combined with energydispersive X-ray spectra(EDS) was used to study 408 particles sampled on four days. Based on the EDS analysis, a total of 8 different particle categories were classified for all 408 particles, including Si-rich, Ca-rich, soot, K-rich, Fe-rich, Pb-rich, Al-rich and other particles.The dominant elements were Si, Al and Ca, which were mainly attributed to mineral dust in the earth's crust such as feldspar and clay. Fe-, Pb-, K-, Al-rich particles and soot mainly originated from anthropogenic sources like firework combustion and biomass burning during the sampling. During the sampling, the pollution mainly came from mineral dust,while the celebration ceremony and religious ritual produced a large quantity of anthropogenic metal-bearing particles on 9 and 25 February 2013. Cement particles also had a minor influence. The data obtained in this study can be useful for developing pollution control strategies. | Bu Duo Yunchen Zhang Lingdong Kong Hongbo Fu Yunjie Hu Jianmin Chen Lin Li A.Qiong | 2015 | Journal of Environmental Sciences2015，27，3： | 4 |
| 7 | New opportunities and challenges of natural products research:When target identification meets single-cell multiomics显示文摘Natural products, and especially the active ingredients found in traditional Chinese medicine(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such,traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and singlecell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. | Yuyu Zhu Zijun Ouyang Haojie Du Meijing Wang Jiaojiao Wang Haiyan Sun Lingdong Kong Qiang Xu Hongyue Ma Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 8 | Numerical Simulations of the Ice Load of a Ship Navigating in Level Ice Using Peridynamics显示文摘In this study,a numerical method was developed based on peridynamics to determine the ice loads for a ship navigating in level ice.Convergence analysis of threedimensional ice specimen with tensile and compression loading are carried out first.The effects of ice thickness,sailing speed,and ice properties on the mean ice loads were also investigated.It is observed that the ice fragments resulting from the icebreaking process will interact with one another as well as with the water and ship hull.The ice fragments may rotate,collide,or slide along the ship hull,and these ice fragments will eventually drift away from the ship.The key characteristics of the icebreaking process can be obtained using the peridynamic model such as the dynamic generation of cracks in the ice sheet,propagation and accumulation of ice fragments,as well as collision,rotation,and sliding of the ice fragments along the ship hull.The simulation results obtained for the ice loads and icebreaking process were validated against those determined from the Lindqvist empirical formula and there is good agreement between the results. | Yanzhuo Xue Renwei Liu Yang Liu Lingdong Zeng Duanfeng Han | 2019 | Computer Modeling in Engineering & Sciences2019，，11： | 3 |
| 9 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 10 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 11 | Studies on the Effects on Growth and Antioxidant Responses of Two Marine Microalgal Species to Uniconazole显示文摘Uniconazole, as a plant growth retardant, can enhance stress tolerance in plants, possibly because of improved antioxidation defense mechanisms with higher activities of superoxide dismutase(SOD) and peroxidase(POD) enzymes that retard lipid peroxidation and membrane deterioration. These years much attention has been focused on the responses of antioxidant system in plants to uniconazole stress, but such studies on aquatic organism are very few. Moreover, no information is available on growth and antioxidant response in marine microalgae to uniconazole. In this paper, the growth and antioxidant responses of two marine microalgal species, Platymonas helgolandica and Pavlova viridis, at six uniconazole concentrations(0-15 mg L-1) were investigated. The results demonstrated that 3 mg L-1 uniconazole could increase significantly chlorophyll a and carbohydrate contents of P. helgolandica(P < 0.05). Higher concentrations(≥12 mg L-1) of uniconazole could inhibit significantly the growth, dry weight, chlorophyll-a and carbohydrate contents of P. helgolandica and P. viridis(P < 0.05). Uniconazole caused a significant increase in lipid peroxidation production(MDA) at higher concentrations(≥ 9 mg L-1). The activities of antioxidant enzymes, superoxide dismutase(SOD) and catalase(CAT) were enhanced remarkably at low concentrations of uniconazole. However, significant reduction of SOD and CAT activities was observed at higher concentrations of uniconazole. | MEI Xueqiao ZHENG Kang WANG Lingdong LI Yantuan | 2014 | Journal of Ocean University of China2014，13，5： | 3 |
| 12 | Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis. | Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun | 2020 | Journal of Molecular Cell Biology2020，12，4： | 2 |
| 13 | Insights into summertime haze pollution events over Shanghai based on online water-soluble ionic composition of aerosols显示文摘 | Huanhuan Du Lingdong Kong Tiantao Cheng Jianmin Chen Jianfei Du Ling Li Xiangao Xia Chunpeng Leng Guanghan Huang | 2011 | Atmospheric Environment2011，，29： | 2 |
| 14 | Functional-template directed self-assembly(FTDSA) of mesostructured organic-inorganic hybrid materials显示文摘Since the discovery of a surfactant directed self-assembly approach for the fabrication of mesoporous silica in 1992,increasing attention has been focused on the design and synthesis of mesostructured functional materials.Organic functionalization is becoming a major topic in this research field,since highly ordered mesostructured organic-inorganic hybrids offer novel functionalities and enhanced performance over their individual components.We begin with a brief overview of the three fundamental methods(post-synthetic grafting technique,co-condensation method,and preparation of periodic mesoporous organosilicas) for the preparation of organically functionalized mesostructured silica,and focus on one of the most promising approaches,which herein was named as functional-template directed self-assembly(FTDSA) approach,and in the eyes of the authors it has a special position in the preparation of this class of hybrid materials.A comprehensive overview of the state of research in the area of FTDSA and its potential applications will be given. | LI LeLe SUN LingDong ZHANG YaWen m YAN ChunHua | 2009 | Science China Chemistry2009，52，11： | 2 |
| 15 | Luminescence resonance energy transfer based on β-NaYF_4:Yb,Er nanoparticles and TRITC dye显示文摘β-NaYF4:Yb,Er nanoparticles (NPs) are one of the most efficient upconversion materials, which can convert near-infrared light to higher-energy light through multiple photon absorptions or energy transfer. In addition, they may be attractive alternative donors for luminescence resonance energy transfer (LRET) studies, because of their sharp absorption and emission profiles, high quantum yields, large anti-stokes shifts, long lifetime, low toxicity, and superior photo-stability. In principle, many problems of fluorescence resonance energy transfer (FRET), such as excitation of acceptors, emission overlaps between donors and acceptors, high background noise, potential toxicity, and instability, can be overcome using β-NaYF4:Yb,Er NPs as energy donors. Because the organic coating induced separation can significantly reduce the energy transfer efficiency and aqueous FRET system is difficult to be applied in devices, we demonstrate a novel NP-dye LRET system in solid state. The emission of the β-NaYF4:Yb,Er NPs at 539 nm overlaps with the absorption of the tetrametrylrhodarnine isothiocyante (TRITC), satisfying the requirement of LRET process. Since TRITC molecules are adsorbed on the β-NaYF4:Yb,Er NPs by an electrostatic interaction, the interaction distance is suitable for LRET without any further modulation. The resultant solid LRET system is ready for the further applications for devices. | SUN LingDong, GU JianQin, ZHANG ShuZhuo, ZHANG YaWen & YAN ChunHua Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Materials Chemistry and Applications & PKU-HKU Joint Lab in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China | 2009 | Science China Chemistry2009，52，10： | 2 |
| 16 | Selective Determination of Nanogram γ-Globulin in Human Blood Serum by Resonance Light Scattering of Functionalized NanoPbS显示文摘Functionalized nano-PbS has been prepared and characterized. The functionalized nanoparticles have good dispersibility in water. Reaction of functionalized nanoPbS with gglobulin (gIgG) results an enhanced resonance light scattering (RLS) around 385 nm. However, when the content of HSA is lower than 0.5 mg ml-1 the RLS enhancement is very weak and is nonlinear to concentration of HSA. Based on these results, a new direct quantitative determination method for gglobulin in blood serum samples without separation is established. Under optimal conditions, the enhanced RLS intensity is in proportion to the gIgG concentration in the range 10500 ng/mL. The limit of detection is 2.75 ng/mL. This method is proved to be very sensitive, rapid, simple and selective for detection of gIgG in blood serum. | LeYuWANG HongQiCHEN LingLI LingDONG TingTingXIA LunWANG | 2004 | Chinese Chemical Letters2004，15，3： | 2 |
| 17 | Synthesis and Tribological Behaviour of 1,3,4-Thiadiazole Schiff Base Derivatives as Multifunctional Lubricant Additives显示文摘Six new 1,3,4-thiadiazole Schiff base derivatives were synthesized and characterized by IR spectroscopy and ~1H NMR spectrometry, and their anti-corrosion properties and thermal stability were investigated via thermogravimetric analysis(TGA) and copper strip corrosion test. The tribological behavior of the said Schiff base derivatives was evaluated on an Optimol SRV~?4 oscillating reciprocating friction and wear tester. The worn surfaces of the steel discs were investigated using a scanning electron microscope(SEM) and energy dispersive X-ray spectrometer(EDS). The test results indicated that these thiadiazole Schiff base derivatives possessed favourable thermal stability, corrosion inhibiting ability and the capability of improving the tribological characteristic of the base oil effectively. It is assumed that the adsorbed additives probably reacted with the steel surfaces during the friction process, resulting in the formation of a protective film composed of sulphates, sulphides and organic nitrogen compounds. | Shen Qiaohong Chen Hongbo Li Lingdong | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 2 |
| 18 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 19 | Controlled synthesis and assembly of ceriabased nanomaterials 显示文摘 | Yuan Quan Duan Haohong Li Lele Sun Lingdong Zhang Yawen Yan Chunhua | 2009 | Journal of Colloid and Interface Science2009，335，2： | 1 |
| 20 | Luminescent properties of Li+ doped nanosized Y203:Eu3+ 显示文摘 | SUN Lingdong QIAN Cheng LIAO Chunsheng | 2001 | Solid State Commun2001，119，6： | 1 |
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