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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | SUPERCONVERGENCE OF DISCONTINUOUS GALERKIN METHOD FOR NONSTATIONARY HYPERBOLIC EQUATION显示文摘AbstractFor the first order nonstationary hyperbolic equation taking the piecewise linear discontinuous Galerkin solver, we prove that under the uniform rectangular partition, such a discontinuous solver, after postprossesing, can have two and half approximative order which is half order higher than the optimal estimate by Lesaint and Raviart under the rectangular partition. | Chen, Y Lin, JF Lin, Q | 2002 | Journal of Computational Mathematics2002，20，4： | 2 |
| 4 | Syntheses and crystal structures of copper(II) complexes derived from 2,4,6- Tris(2-pyridyl)-1,3,5-triazine显示文摘 | Zheng Y Q Xu W Lin F | 2006 | J Coord Chem2006，59，： | 1 |
| 5 | Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status 显示文摘 | Liu Z Q Han K Lin Y J | 2002 | Biochimica et Biophysica Acta2002，157，： | 1 |
| 6 | Delay-range-dependent stability for systems with time-varying delay显示文摘 | He Y Wang Q G Lin C | 2007 | Automatica2007，43，： | 1 |
| 7 | The effects of food and the sum of effective temperature on the embryonic development of the seahorse,Hippocampus kuda Bleeker 显示文摘 | LIN Q GAO Y SHENG J | 2007 | Aquacuhure2007，262，24： | 1 |
| 8 | TiN/TiC Multi-layer Films Deposited by Pulse Biased Arc Ion Plating显示文摘 | ZHAO Y H LIN G Q XIAO J Q | 2010 | Vacuum2010，85，1： | 1 |
| 9 | HLA-matching potential of an established human embryonic stem cell bank in China显示文摘 | LIN G XIE Y B OU Y Q | 2009 | Cell Stem Cell2009，5，： | 1 |
| 10 | Production of tetraploid pearl oyster (Pinctada martensii Dunker) by inhibiting the first polar body in eggs from triploids 显示文摘 | He M Lin Y Shen Q | 2000 | Journal of Shellfish Research2000，19，1： | 1 |
| 11 | Chemo-and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs显示文摘 | Zhang H Q Lin AP Sun Y | 2001 | Acta Pharmacol Sini2001，22，12： | 1 |
| 12 | Fractional Fourier transform for elliptical Gaussian beams显示文摘 | Cai Y J Lin Q | 2003 | Opt Commun2003，217，： | 1 |
| 13 | Hydrogen peroxide mediates defence responses induced by chitosans of different molecular weights in rice显示文摘 | Lin W L Hu X Y Zhang W Q John R W Cai W M | 2005 | Journal of Plant Physiology2005，162，8： | 1 |
| 14 | Correlation between Indian Ocean summer monsoon and North Atlantic climate during the Holocene 显示文摘 | Hong Y T Hong B Lin Q H | 2003 | Earth and Planetary Science Letters2003，211，： | 1 |
| 15 | Recollements of extension algebras显示文摘 | Chen Q H Lin Y N | 2003 | Science in China: Series A2003，46，4： | 1 |
| 16 | A study of quantum confinement properties of photogenerated charges in zno nanoparticles by surface photovoltage spectroscopy显示文摘 | LIN Y H WANG DJ ZHAO Q D | 2004 | J Phys Chern B2004，108，10： | 1 |
| 17 | The Novel Anti-tumor Agents of 4-Triazol-1,8-naphthalimides:Synthesis, Cytotoxicity, DNA Intercalation and Photocleavage 显示文摘 | Li X L Lin Y J Wang Q Q | 2011 | Eur J Med Chem2011，46，4： | 1 |
| 18 | The distributions of particulate heavy metals and its indication to the transfer of sediments in the Changjiang Estuary and Hangzhou Bay, China 显示文摘 | Che Y He Q Lin W Q | 2003 | Marine Pollution Bulletin2003，46，1： | 1 |
| 19 | Degradation of 2,4,6-trinitrotoluene ( TNT ) from explosive wastewater using nanoscale zero-valent iron显示文摘 | Zhang X Lin Y M Shan X Q | 2010 | Chemical Engineering Journal2010，158，3： | 1 |
| 20 | Mechani-cal stretch inhibits adipogenesis and stimulates osteogenesis of adipose stem cells显示文摘 | Yang X Cai X Wang J Tang H Yuan Q Gong P Lin Y | | 0，，： | 1 |
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