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| 1 | TOTAL SYNTHESIS OF CLAUSENAMIDE显示文摘TOTAL SYNTHESIS OF CLAUSENAMIDETOTALSYNTHESISOFCLAUSENAMIDE￥ErChangRAO;HaoHONG;JiaChongCHENG;GuangZhongYANG;HanSenLIN;andLian... | Er Chang RAO Hao HONG Jia Chong CHENG Guang Zhong YANG Han Sen LIN andLiang HUANG(Institute of Mareia Medica. Chinese Academy of Medical Sciences1 Xian Nong Tan St .Beijing 100050) | 1994 | Chinese Chemical Letters1994，5，4： | 4 |
| 2 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 3 | Effects of Delayed Second Cochlear Implant显示文摘Objective Since Helms' successful bilateral cochlear implantation with good results in 1996, there have been increasing number of reports on bilateral cochlear implantation. Most second device have been implantated within one year after the first. Considering effects of long time auditory deprivation, it is not clear whether a delayed second cochlear implant serves to add additional benefits and how it may interact with central nervous system plasticity. Methods Three cases who received delayed second cochlear implants at People's Hospital of Peking University from 2002 to 2005 were reviewed. The interval between the first and second implants was longer than 2 years in all three patients. Sound perception, and unilateral/bilateral speech discrimination in quiet and noise were evaluated. In addition, GAP detection test was conducted in one patient. Results In one case, having both implants on provided improved performance compared to using only one implant both in quiet and noise. Presumably due to visual interference from lip-reading or short interval between second implant and testing, one patient showed no improvement from using the second implant either in quiet or noise, while the last case demonstrated additional benefits from the second implant only in quiet. In all three patients, performance in recognizing the four tones in Mandarin was superior over word recognition. Conclusions Considerable plasticity in the cerebral auditory center is preserved, despite long acoustic deprivation in some children who have received unilateral cochlear implant. Delayed second implants can result in significant improvements in some of these children. Visual interference from lip-reading may be an obstacle during retraining. The better recognition of tones in the Mandarin language may represent a different sound discrimination mechanism in the auditory system, although it may also be related to the signal processing mechanisms of the implant used (MED-EL COMBI 40+). | XIA Rui-ming1, WU Xi-hong2, JANG Zi-gang1, JING Yuan-yuan1, LIN Yun-juan1, YU Li-sheng1 1. Department of Otolaryngology, People’s Hospital, Peking University, P. R. China 11, Xizhimen South St, 100044 Beijing, P.R. China 2. Speech and Hearing Research Center, Peking University, China R.M. Xia, X.H. Wu, Z.G. Jang, Y.Y. Jing, Y.J. Lin, L.S.Yu | 2006 | Journal of Otology2006，1，2： | 2 |
| 4 | Vascular endothelial growth factor expression and angiogenesis induced by chronic cerebral hypoperfusion in rat brain显示文摘 | Hai J Li ST Lin Q | 2003 | Neurosurgery2003，53，4： | 1 |
| 5 | B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetalI 显示文摘 | Abrams ST Lakum T Lin K | 2007 | Blood2007，109，： | 1 |
| 6 | Burnout among Hospital Nurses in China显示文摘 | Lin F St John W McVeigh C | 2009 | J Nurs Manag2009，17，3： | 1 |
| 7 | Acute disseminated encephalomyelitis :a follow-up study in Taiwan显示文摘 | Lin CH Jeng JS Hsien ST | 2007 | J Neurol Neurosurg Psychiatry2007，78，2： | 1 |
| 8 | Nitric oxide induces cyclooxyenase expression and inhibits cell growth in colon cancer cell lines 显示文摘 | Lin Q Chan ST Mahendran LIR | 2003 | Carcinogenesis2003，24，4： | 1 |
| 9 | A study of there fenal patterns of obstetric clinic sand the performance of receiving neonatal intensive care units in Taiwan显示文摘 | Lin CH Wang J | 1997 | Public Health1997，111，3： | 1 |
| 10 | Epidermal denervation and its effects on keratinocytes and Langerhans cells 显示文摘 | Hsieh ST Choi S Lin WM | 1996 | J Neurocyto1996，25，9： | 1 |
| 11 | Burnout among hospital nurses in China显示文摘 | Lin F St John W Mcveigh C | | 0，，03： | 1 |
| 12 | Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP upregulation显示文摘 | Lin MT Chang CC Chen ST | 2004 | J Biol Chem2004，279，24： | 1 |
| 13 | Hinokitiol induces au- tophagy inmurinc breast and colorectal cancer cells 显示文摘 | Wang WK Lin ST Chang WW | 2016 | En- viron Toxicol2016，31，1： | 1 |
| 14 | Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases显示文摘 | Tu ST Wang IW Lin HF | 2010 | J Investig Med2010，58，6： | 1 |
| 15 | Inhibitory effects of Zuo-Jin-Wan andits alkaloidal ingredients on activator protein 1,nuclear factor-κB,and cellular transformation in HepG2 cells显示文摘 | De CC Lin LJ Kao ST | 2011 | Fitoterapia2011，82，69： | 1 |
| 16 | Cyr61 Expression Confers Resistance to Apoptosis in Breast Cancer MCF-7cells by a Mechanism of NF-{kappa} B-dependent XIAP Up-Regulation 显示文摘 | Lin MT Chang CC Chen ST | 2004 | Biol Chem2004，279，24： | 1 |
| 17 | A study of there fenalpatterns of obstetric clinic sand the performance ofreceiving neonatal intensive care units inTaiwan显示文摘 | Wang ST Lin CH Wang J | 1997 | PublicHealth1997，111，3： | 1 |
| 18 | Hepatitis B virus markers in Chinese twins显示文摘 | Lin TM Chen CJ Wu MM Yang CS Chen JS Lin CC Kwang TY Hsu ST Lin SY Hsu LC | 1989 | Anticancer Res1989，9，3： | 1 |
| 19 | Stabilization of pSW100 from pantoea stewartii by the F conjugation 显示文摘 | Lin MH Liu ST | 2008 | J Bacteriol2008，190，0： | 1 |
| 20 | Nitricoxide indece cyclooxygenase expression and inhibits cell growth in colon cancer cell lines 显示文摘 | Lin Q Chan ST Mahendran LIR | 2003 | Carcinogenesis2003，24，4： | 1 |
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