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| 1 | Dendrochronology-based stand growth estimation of Larix olgensis forest in relation with climate on the eastern slope of Changbai Mountain, NE China显示文摘Changbai 山的东方斜坡与很少人的骚乱由纯落叶松森林(Larix olgensis ) 被描绘。到在这个区域的气候的树生长的反应仍然保持未知。同时,很少气候变化怎么影响能作为一个三维的树生长索引被认出的生物资源增加被知道。这研究的目的是调查气候效果在上光线并且 Changbai 的东方斜坡上的落叶松的生物资源生长山。树戒指宽度年表和吝啬的年度生物资源增长用树戒指数据被建立。我们使用了关联分析和多重回归分析从 1957 ~ 2009 探索在落叶松生长和气候的因素之间的关系。树戒指生长和吝啬的年度生物资源增长主要并且显著地是的结果表演在月之中与细微差别到上一年影响了气候的变量。温度更一致地并且强烈比是降水的被相关到年表和吝啬的年度生物资源增长。温度是在 Changbai 山上限制落叶松生长的主要因素,温暖的进行中的气候可以加速种的生长。区域的当前的看台生物资源 240.72 是 Mg 獵? | Bo LIN Qianqian XU Wenhui LIU Guochun ZHANG Qiongyao XU Qijing LIU | 2013 | Frontiers of Earth Science2013，7，4： | 5 |
| 2 | Fabrication of Nanoscale Step Height Structure Using Atomic Layer Deposition Combined with Wet Etching显示文摘The current techniques used for the fabrication of nanosteps are normally done by layer growth and then ion beam thinning. There are also extra films grown on the step surfaces in order to reduce the roughness. So the whole process is time consuming. In this paper, a nanoscale step height structure is fabricated by atomic layer deposition(ALD) and wet etching techniques. According to the traceable of the step height value, the fabrication process is controllable. Because ALD technology can grow a variety of materials, aluminum oxide(Al_2O_3) is used to fabricate the nanostep. There are three steps of Al_2O_3 in this structure including 8 nm, 18 nm and 44 nm. The thickness of Al_2O_3 film and the height of the step are measured by anellipsometer. The experimental results show that the thickness of Al_2O_3 film is consistent with the height of the step. The height of the step is measured by AFM. The measurement results show that the height is related to the number of cycles of ALD and the wet etching time. The bottom and the sidewall surface roughness are related to the wet etching time. The step height is calibrated by Physikalisch-Technische Bundesanstalt(PTB) and the results were 7.5±1.5 nm, 15.5±2.0 nm and 41.8±2.1 nm, respectively. This research provides a method for the fabrication of step height at nanoscale and the nanostep fabricated is potential used for standard references. | WANG Chenying YANG Shuming JING Weixuan REN Wei LIN Qijing ZHANG Yijun JIANG Zhuangde | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 3 |
| 3 | Flexible temperature sensor with high sensitivity ranging from liquid nitrogen temperature to 1200℃显示文摘Flexible temperature sensors have been extensively investigated due to their prospect of wide application in various flexible electronic products.However,most of the current flexible temperature sensors only work well in a narrow temperature range,with their application at high or low temperatures still being a big challenge.This work proposes a flexible thermocouple temperature sensor based on aerogel blanket substrate,the temperature-sensitive layer of which uses the screen-printing technology to prepare indium oxide and indium tin oxide.It has good temperature sensitivity,with the test sensitivity reaching 226.7μV℃^(−1).Most importantly,it can work in a wide temperature range,from extremely low temperatures down to liquid nitrogen temperature to high temperatures up to 1200℃,which is difficult to be achieved by other existing flexible temperature sensors.This temperature sensor has huge application potential in biomedicine,aerospace and other fields. | Zhaojun Liu Bian Tian Zhuangde Jiang Shuimin Li Jiaming Lei Zhongkai Zhang Jiangjiang Liu Peng Shi Qijing Lin | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 4 | A flexible and wearable NO_(2)gas detection and early warning device based on a spraying process and an interdigital electrode at room temperature显示文摘Flexible sensors used to detect NO_(2) gas generally have problems such as poor repeatability,high operating temperature,poor selectivity,and small detection range.In this work,a new spraying platform with a simple structure,low cost,and good film-forming consistency was designed and built to make a sensitive film(rGO/SnO_(2))for NO_(2) gas sensors.The relationship between the solid content of rGO and SnO_(2)nanoparticles,annealing temperature,and sensor performance was studied.The results show that the interdigital electrode-sensitive film formed by spraying 0.25 ml of a 0.4 wt%rGO/SnO_(2)mixture and annealing at 250℃exhibited the best comprehensive performance for NO_(2) detection.The sensor's response value for 100 ppm NO_(2) gas was 0.2640 at room temperature(25℃),and the response time and recovery time were 412.4 s and 587.3 s,respectively.In the range of 20-100 ppm,the relationship between the response and NO_(2) concentration was linear,and the correlation coefficient was 0.9851.In addition,a soft-monitoring node module with an overlimit warning function for NO_(2) gas was designed and manufactured based on flexible electronics.Finally,the flexible sensor and node module were embedded into woven fabric that could be used to make a mask or a watch that could detect NO_(2) gas,realizing the practical application of flexible NO_(2) gas sensors in the field of wearable electronics. | Fuzheng Zhang Qijing Lin Feng Flan Zuowei Wang Bian Tian Libo Zhao Tao Dong Zhuangde Jiang | 2022 | Microsystems & Nanoengineering2022，8，2： | 1 |
| 5 | Wheel Setting Error Modeling and Compensation for Arc Envelope Grinding of Large-Aperture Aspherical Optics显示文摘Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices,large-aperture astronomical telescopes,and high-resolution space cameras.In this study,the arc envelope grinding process of large-aperture aspherical optics is investigated using a CM1500 precision grinding machine with a maximum machinable diameter ofΦ1500 mm.The form error of the aspherical workpiece induced by wheel setting errors is analytically modeled for both parallel and cross grinding.Results show that the form error is more sensitive to the wheel setting error along the feed direction than that along the lateral direction.It is a bilinear function of the feed-direction wheel setting error and the distance to the optical axis.Based on the error function above,a method to determine the wheel setting error is proposed.Subsequently,grinding tests are performed with the wheels aligned accurately.Using a newly proposed partial error compensation method with an appropriate compensation factor,a form error of 3.4μm peak-to-valley(PV)for aΦ400 mm elliptical K9 glass surface is achieved. | Changsheng Li Lin Sun Zhaoxiang Chen Jianfang Chen Qijing Lin Jianjun Ding Zhuangde Jiang | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 1 |
| 6 | An integrated MEMS tactile tri-axial micro-force probe sensor for minimally invasive surgery显示文摘 | Wang Weizhong Zhao Yulong Lin Qijing | 2009 | Proceedings of the 2009 IEEE 3rd International Conference on Nano/MolecularMedicine and Engineering Tainan Taiwan October 18-212009，，： | 1 |
| 7 | A large-area bionic skin for high-temperature energy harvesting applications显示文摘For the large amount of waste heat wasted in daily life and industrial production,we propose a new type of flexible thermoelectric generators(F-TEGs)which can be used as a large area bionic skin to achieve energy harvesting of thermal energy.With reference to biological structures such as pinecone,succulent,and feathers,we have designed and fabricated a biomimetic flexible TEG that can be applied in a wide temperature range which has the highest temperature energy harvesting capability currently.The laminated free structure of the bionic F-TEG dramatically increases the efficiency and density of energy harvesting.The F-TEGs(single TEG only 101.2 mg in weight),without an additional heat sink,demonstrates the highest output voltage density of 286.1 mV/cm^(2)and the maximum power density is 66.5 mW/m^(2) at a temperature difference of nearly 1000℃.The flexible characteristics of F-TEGs make it possible to collect the diffused thermal energy by flexible attachment to the outer walls of high-temperature pipes and vessels of different diameters and shapes.This work shows a new design and application concept for flexible thermal energy collectors,which fills the gap of flexible energy harvesting in high-temperature environment. | Zhaojun Liu Bian Tian Yao Li Jiaming Lei Zhongkai Zhang Jiangjiang Liu Qijing Lin Chengkuo Lee Zhuangde Jiang | 2023 | Nano Research2023，16，7： | 0 |
| 8 | Highly sensitive flexible heat flux sensor based on a microhole array for ultralow to high temperatures显示文摘With the growing demand for thermal management of electronic devices,cooling of high-precision instruments,and biological cryopreservation,heat flux measurement of complex surfaces and at ultralow temperatures has become highly imperative.However,current heat flux sensors(HFSs)are commonly used in high-temperature scenarios and have problems when applied in low-temperature conditions,such as low sensitivity and embrittlement.In this study,we developed a flexible and highly sensitive HFS that can operate at ultralow to high temperatures,ranging from−196°C to 273°C.The sensitivities of HFSs with thicknesses of 0.2 mm and 0.3 mm,which are efficiently manufactured by the screen-printing method,reach 11.21μV/(W/m2)and 13.43μV/(W/m2),respectively.The experimental results show that there is a less than 3%resistance change from bending to stretching.Additionally,the HFS can measure heat flux in both exothermic and absorptive cases and can measure heat flux up to 25 kW/m2.Additionally,we demonstrate the application of the HFS to the measurement of minuscule heat flux,such as heat dissipation of human skin and cold water.This technology is expected to be used in heat flux measurements at ultralow temperatures or on complex surfaces,which has great importance in the superconductor and cryobiology field. | Le Li Bian Tian Zhongkai Zhang Meng Shi Jiangjiang Liu Zhaojun Liu Jiaming Lei Shuimin Li Qijing Lin Libo Zhao Zhuangde Jiang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 9 | Improved phase retrieval in holographic data storage based on a designed iterative embedded data显示文摘Embedded data are used to retrieve phases quicker with high accuracy in phase-modulated holographic data storage(HDS).We propose a method to design an embedded data distribution using iterations to enhance the intensity of the high-frequency signal in the Fourier spectrum.The proposed method increases the antinoise performance and signal-to-noise ratio(SNR)of the Fourier spectrum distribution,realizing a more efficient phase retrieval.Experiments indicate that the bit error rate(BER)of this method can be reduced by a factor of one after 10 iterations. | Changyu YU Suping WANG Ruixian CHEN Jianying HAO Qijing ZHENG Jinyu WANG Xianying QIU Kun WANG Dakui LIN Yi YANG Hui LI Xiao LIN Xiaodi TAN | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 10 | A thin-film temperature sensor based on a flexible electrode and substrate显示文摘Accurate temperature measurements can efficiently solve numerous critical problems and provide key information.Herein,a flexible micro-three-dimensional sensor,with a combination of platinum and indium oxide to form thermocouples,is designed and fabricated by a microfabrication process to achieve in situ real-time temperature measurements.The stability and reliability of the sensor are greatly improved by optimizing the process parameters,structural design,and preparation methods.A novel micro-three-dimensional structure with better malleability is designed,which also takes advantage of the fast response of a two-dimensional thin film.The as-obtained flexible temperature sensor with excellent stability and reliability is expected to greatly contribute to the development of essential components in various emerging research fields,including bio-robot and healthcare systems.The model of the application sensor in a mask is further proposed and designed to realize the collection of health information,reducing the number of deaths caused by the lack of timely detection and treatment of patients. | Zhaojun Liu Bian Tian Bingfei Zhang Jia ngjiang Liu Zhongkai Zhang Song Wang Yunyun Luo Li bo Zhao Peng Shi Qijing Lin Zhuangde Jiang | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 11 | Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer显示文摘Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric cancer.However,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal measure.Existing researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively lacking.This study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these patients.Methods:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome sequencing.Bioinformatics were used to analyze cell subtypes,metabolic pathways,and molecular signaling pathways.Changes in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)analyses.Finally,a multi-scale agent-based model(ABM)was constructed.The effects of combination treatment were further validated in nude mice to verify these effects predicted by the ABM.Results:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly overexpressed.Meanwhile,tumor-derived GLS1 microvesicles drove M2macrophage polarization.Furthermore,angiogenesis promoted trastuzumab resistance.IHC showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and nudemice.Mechanistically,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and in vivo experiments,we confirmed that the combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy had the best effect in reversing trastuzumab resistance in HER2-positive gastric cancer.Conclusions:This study revealed that tumor cells secrete GLS1 microvesicles via CDC42 to promote glutamine metabolism,M2 macrophage polarization,and pro-angiogenic function of macrophages,leading to acquired trastuzumab resistance in HER2-positive gastric cancer.A combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy may provide a new insight into reversing trastuzumab resistance. | Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing Wu Qiong Huang Le Yu Fenghua Wang Min Shi | 2023 | Cancer Communications2023，43，8： | 0 |
| 12 | Piezoelectric-AIN resonators at two-dimensional flexural modes for the density and viscosity decoupled determination of liquids显示文摘A micromachined resonator immersed in liquid provides valuable resonance parameters for determining the fluidic parameters.However,the liquid operating environment poses a challenge to maintaining a fine sensing performance,particularly through electrical characterization.This paper presents a piezoelectric micromachined cantilever with a stepped shape for liquid monitoring purposes.Multiple modes of the proposed cantilever are available with full electrical characterization for realizing self-actuated and seif-sensing capabilities.The focus is on higher flexural resonances,which nonconventionally feature two-dimensional vibration modes.Modal analyses are conducted for the developed cantilever under flexural vibrations at different orders.Modeling explains not only the basic length-dominant mode but also higher modes that simultaneously depend on the length and width of the cantilever.This study determines that the analytical predictions for resonant frequency in liquid media exhibit good agreement with the experimental results.Furthermore,the experiments on cantilever resonators are performed in various test liquids,demonstrating that higher-order flexural modes allow for the decoupled measurements of density and viscosity.The measurement differences achieve 0.39%in density and 3.50%in viscosity,and the frequency instability is below 0.05%o.On the basis of these results,design guidelines for piezoelectric higher-mode resonators are proposed for liquid sensing. | Linya Huang Wei Li Guoxi Luo Dejiang Lu Libo Zhao Ping Yang Xiaozhang Wang Jiuhong Wang Qijing Lin Zhuangde Jiang | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
| 13 | The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-βsignaling显示文摘Liver fibrosis is a key transformation stage and also a reversible pathological process in various types of chronic liver diseases.However,the pathogenesis of liver fibrosis still remains elusive.Here,we report that the calcium binding protein A11(S100A11)is consistently upregulated in the integrated data from GSE liver fibrosis and tree shrew liver proteomics.S100A11 is also experimentally activated in liver fibrosis in mouse,rat,tree shrew,and human with liver fibrosis.While overexpression of S100A11 in vivo and in vitro exacerbates liver fibrosis,the inhibition of S100A11 improves liver fibrosis.Mechanistically,S100A11 activates hepatic stellate cells(HSCs)and the fibrogenesis process via the regulation of the deacetylation of Smad3 in the TGF-βsignaling pathway.S100A11 physically interacts with SIRT6,a deacetylase of Smad2/3,which may competitively inhibit the interaction between SIRT6 and Smad2/3.The subsequent release and activation of Smad2/3 promote the activation of HSCs and fibrogenesis.Additionally,a significant elevation of S100A11 in serum is observed in clinical patients.Our study uncovers S100A11 as a novel profibrogenic factor in liver fibrosis,which may represent both a potential biomarker and a promising therapy target for treating liver fibrosis and fibrosis-related liver diseases. | Tingting Zhu Linqiang Zhang Chengbin Li Xiaoqiong Tan Jing Liu Huiqin Li Qijing Fan Zhiguo Zhang Mingfeng Zhan Lin Fu Jinbo Luo Jiawei Geng Yingjie Wu Xiaoju Zou Bin Liang | 2022 | Journal of Genetics and Genomics2022，49，4： | 0 |
| 14 | A bionic approach for the mechanical and electrical decoupling of an MEMS capacitive sensor in ultralow force measurement显示文摘Capacitive sensors are efficient tools for biophysical force measurement,which is essential for the exploration of cellular behavior.However,attention has been rarely given on the influences of external mechanical and internal electrical interferences on capacitive sensors.In this work,a bionic swallow structure design norm was developed for mechanical decoupling,and the influences of structural parameters on mechanical behavior were fully analyzed and optimized.A bionic feather comb distribution strategy and a portable readout circuit were proposed for eliminating electrostatic interferences.Electrostatic instability was evaluated,and electrostatic decoupling performance was verified on the basis of a novel measurement method utilizing four complementary comb arrays and applicationspecific integrated circuit readouts.An electrostatic pulling experiment showed that the bionic swallow structure hardly moved by 0.770 nm,and the measurement error was less than 0.009% for the area-variant sensor and 1.118% for the gap-variant sensor,which can be easily compensated in readouts.The proposed sensor also exhibited high resistance against electrostatic rotation,and the resulting measurement error dropped below 0.751%.The rotation interferences were less than 0.330 nm and(1.829×10^(-7))°,which were 35 times smaller than those of the traditional differential one.Based on the proposed bionic decoupling method,the fabricated sensor exhibited overwhelming capacitive sensitivity values of 7.078 and 1.473 pF/μm for gap-variant and area-variant devices,respectively,which were the highest among the current devices.High immunity to mechanical disturbances was maintained simultaneously,i.e.,less than 0.369% and 0.058% of the sensor outputs for the gap-variant and area-variant devices,respectively,indicating its great performance improvements over existing devices and feasibility in ultralow biomedical force measurement. | Wendi GAO Bian TIAN Cunlang LIU Yingbiao MI Chen JIA Libo ZHAO Tao LIU Nan ZHU Ping YANG Qijing LIN Zhuangde JIANG Dong SUN | 2023 | Frontiers of Mechanical Engineering2023，18，2： | 0 |
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