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| 1 | Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods显示文摘OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis(KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods.METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, andnew prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively.RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found.Five new fuming-washing recipes for KOA were developed.CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs,and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao(Herba Speranskiae Tuberculatae), Honghua(Flos Carthami), Niuxi(Radix Achyranthis Bidentatae), Shenjincao(Herba Lycopodii Japonici), Weilingxian(Radix et Rhizoma Clematidis Chinensis), Chuanwu(Radix Aconiti), Haitongpi(Cortex Erythrinae Variegatae), Ruxiang(Olibanum),Danggui(Radix Angelicae Sinensis), Caowu(Radix Aconiti Kusnezoffii), Moyao(Myrrha), and Aiye(Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. | Jun Liu Jianke Pan Yanping Wang Dingkun Lin Dan Shen Hongjun Yang Xiang Li Minghui Luo Xuewei Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 32 |
| 2 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 3 | Calculation analysis of sustained casing pressure in gas wells显示文摘Sustained casing pressure (SCP) in gas wells brings a serious threat to worker safety and environmental protection. According to geological conditions, wellbore structure and cement data of gas wells in the Sichuan-Chongqing region, China, the position, time, environmental condition and the value of SCP have been analyzed. On this basis, the shape of the pressure bleed-down plot and pressure buildup plot were diagnosed and the mechanism of SCP has been clarified. Based on generalized annular Darcy percolation theory and gas-liquid two-phase fluid dynamics theory, a coupled mathematical model of gas migration in a cemented annulus with a mud column above the cement has been developed. The volume of gas migrated in the annulus and the value of SCP changing with time in a gas well in Sichuan have been calculated by this model. Calculation results coincided well with the actual field data, which provide some reference for the following security evaluation and solution measures of SCP. | Zhu Hongjun Lin Yuanhua Zeng Dezhi Zhang Deping Wang Feng | 2012 | Petroleum Science2012，9，1： | 12 |
| 4 | Cloning of the full-length gene of activin receptor-interacting protein2a and characterization of its interaction with ActR Ⅱ A显示文摘为了调查细胞内部的信号 transduction 的机制,由 activin 受体调停了,编码新奇 activin 的全身的基因交往受体的 protein2a (ARIP2a ) 从一个老鼠大脑 cDNA 图书馆被识别。ARIP2a 和 ARIP2 和在导致 activin 的 RAW264 的 ARIP2 的序列。7 房间被比较,并且在 ARIP2a 和 ActRIIA 之间的相互作用被证实。序列分析表明除了 99 th 氨基酸。RT-PCR 试金证明 ARIP2a mRNA 高度在大脑,垂体和睾丸被表示,并且中等在胰和卵巢,但是在另外的纸巾无法发现。而, ARIP2 mRNA 广泛地在我们测试了的所有老鼠纸巾被散布。而且, ARIP2a mRNA 的表示显著地在刺激 activin 的 RAW264 被减少。7 个房间;然而, ARIP2 mRNA 的表示被增加。另外,在 ARIP2a 之间的相互作用和 activin 类型 IIA 受体(ActRIIA ) 被哺乳动物的二混血儿的试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也与 activin 类型 II 受体(ActRIIA ) 交往被哺乳动物的 two-hybird 试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也作为 ARIP 家庭的一篇小说与 activin 类型 II 受体交往。 | CUI Xueling TAI Guixiang ZHANG Hongjun FANG Lin LIU Zhonghui | 2007 | Progress in Natural Science:Materials International2007，17，2： | 5 |
| 5 | Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells显示文摘Baicalin,a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi,has been shown to effectively inhibit cell apoptosis.Therefore,we assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis.PC12 cells exposed to colistin sulfate(62.5–500μg/mL)for 24 hours resulted in PC12 cell apoptosis.In addition,caspase-3 activity,lactate dehydrogenase level and free radical content increased in a dose-dependent manner.Subsequently,PC12 cells were pretreated with baicalin(25,50 and 100μg/mL),and exposed to 125μg/mL colistin sulfate.Cell morphology markedly changed,and cell viability increased.Moreover,caspase-3 activity,lactate dehydrogenase level and free radical content decreased.Results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury,and reducing caspase-3 activity and lactate dehydrogenase activity. | Hong Jiang Pengfei Lv Jichang Li Hongjun Wang Tiezhong Zhou Yingzi Liu Wei Lin | 2013 | Neural Regeneration Research2013，8，28： | 4 |
| 6 | Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system显示文摘Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution.However,there have not been any similar sys-tems developed for Clostridium,an important bacterial genus.Here we report a novel two-step strategy for de-veloping controllable hypermutable cells of Clostridium acetobutylicum,an important and representative indus-trial strain.Firstly,the mutS/L operon essential for methyl-directed mismatch repair(MMR)activity was inactivated from the genome of C.acetobutylicum to generate hy-permutable cells with over 250-fold increased mutation rates.Secondly,a proofreading control system carrying an inducibly expressed mutS/L operon was constructed.The hypermutable cells and the proofreading control system were integrated to form a controllable hypermut-able system SMBMutC,of which the mutation rates can be regulated by the concentration of anhydrotetracycline(aTc).Duplication of the miniPthl-tetR module of the proof-reading control system further signifi cantly expanded the regulatory space of the mutation rates,demonstrating hypermutable Clostridium cells with controllable mutation rates are generated.The developed C.acetobutylicum strain SMBMutC2 showed higher survival capacities than the control strain facing butanol-stress,indicating greatly increased evolvability and adaptability of the controllable hypermutable cells under environmental challenges. | Guodong Luan Zhen Cai Fuyu Gong Hongjun Dong Zhao Lin Yanping Zhang Yin Li | 2013 | Protein & Cell2013，4，11： | 4 |
| 7 | Elemental composition and risk assessment of heavy metals in the PM10 fractions of road dust and roadside soil显示文摘A total of 64 dust samples were analyzed to determine the size distribution and elemental composition of the PM10 fraction, including42 road dust(RD), 12 roadside soil(RSD), and 10 park road dust(PRD) samples. The mass of dust smaller than 20μm was dominated by particles sized 2.5-16 μm, which accounted for 85%, 88%, and 87% of the RD, PRD, and RSD, respectively. Additionally, crustal elements accounted for 30.14%, 36.35%, and 37.14% of the PMio fractions of the RD, RSD, and PRD, respectively. The most abundant trace elements in RD, RSD, and PRD were Zn, Mn, and Cu (range, 277 to 874 mg/kg). Moreover, the /geo values revealed all dusts were contaminated with Pb, Zn, Cu, Sb, Sn, and Cd. Health risk assessment showed that Mn, Ni, Cu, Zn, Cd, Sb, and Pb in the PM10 fraction of three types of dusts posed non-cancer risks to children but posed no non-cancer risk to adults. Additionally, As, Ni, and Cd posed no cancer risk to inhabitants. | Jing Zhang Lin Wu Yanjie Zhang Fenghua Li Xiaozhen Fang Hongjun Mao | 2019 | Particuology2019，17，3： | 4 |
| 8 | Angular-based spatially resolved laser-induced breakdown spectroscopy: a new technique for the effective enhancement of signals without an external time delay system显示文摘In this study, we developed a novel angularbased spatially resolved laser-induced breakdown spectroscopy(ABSR-LIBS) technique. This new method allows the spatially resolved spectroscopic properties of laserinduced plasma to be investigated using different angles and polar distances with a spatially adjustable fiber optics probe. The experimental evaluations suggested that the intensity of the Al signal distributions in the ‘‘side-view''depended greatly on the angle of the collection probe. The location of a collection probe at 50° would facilitate efficient spectral collection and minimize the disturbance of the plasma plume. The spectral signals in the plasma emissions had different distribution at various polar distances using the same collection angle, and the highest signal intensity was observed between 15 and 35 mm polar distances. This ABSR-LIBS technique improved both the LIBS signal and the maximum emission intensity of Al atoms by several times at the best spatial position in our experimental conditions. Furthermore, we successfully obtained well-resolved line emission spectroscopy signals without any external time delay using a nongated spectrometer based on the ABSR-LIBS system. We consider that the ABSR-LIBS technique has great potential for obtaining new insights with laser-induced plasma instruments and it could facilitate the development of a low-cost instrument. | Qingyu Lin Xu Wang Guanghui Niu Hongjun Lai Xiaoqin Zhu Kunping Liu Tao Xu Yixiang Duan | 2014 | Chinese Science Bulletin2014，59，27： | 3 |
| 9 | Comprehensive Investigation and Assessment of Nutrient and Heavy Metal Contamination in the Surface Water of Coastal Bohai Sea in China显示文摘With the rapid development of industrialization and urbanization of coastal regions,eutrophication and metal pollution have caused serious environmental problems in China.To better understand the potential environmental risks associated with nutrients and heavy metals,the surface water was comprehensively investigated in the coastal Bohai Sea.A total of 150 sites were sampled from seven coastal regions,and the concentrations of nutrients(DIN and DIP)and metals(Cd,Pb,Zn,Cu,Cr,As and Hg)in the surface seawater were measured.The results showed that the DIN concentration of about 50%sites exceeded the Grade-I of Seawater Quality Standard of China.Due to high concentrations of DIN,the status of eutrophication was serious in the Bohai Bay and Shuangtaizi Estuary.According to Seawater Quality Standard of China,Pb,Zn,Hg and Cu were the main metal pollutants in the coastal Bohai Sea.There was generally low ecological risk caused by heavy metals,but certain hotspots existed near Shuangtaizi Estuary and Changxingdao Island. | LIN Heshan LI Hongjun YANG Xiaolong XU Zizhou TONG Yindong YU Xingguang | 2020 | Journal of Ocean University of China2020，19，4： | 2 |
| 10 | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction显示文摘 | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie Celeste C. Finnerty | 2013 | Mediators of Inflammation2013，，： | 2 |
| 11 | Electronic structure of exfoliated millimeter-sized monolayer WSe2 on silicon wafer显示文摘The mono layer WSe2 is in teresting and important for future application in nanoelectronics,spintronics and valleytronics devices,because it has the largest spin splitting and Ion gest valley coherence time among all the known monolayer transition-metal dichalcogenides(TMDs).Toobtain the large-area monolayer TMDs'crystal is the first step to manu facture scalable and high-performance electronic devices.In this letter,we have successfully fabricated millimeter-sized mono layer WSe2 single crystals with very high quality,based on our improved mecha nicalexfoliation method.With such superior samples,using standard high resolution angle-resolved photoemission spectroscopy,we didcomprehe nsive electronic band structure measurements on our mono layer WSe2.The overall band features point it to be a 1.2 eV direct bandgap semico nductor.Its spin splitting of the valence band at K point is found as 460 meV,which is 30 meV less than the corresponding band splitting in its bulk counterpart.The effective hole masses of valence bands are determined as 2.344 me atГ,and 0.529 me as well as 0.532 meat K for the upper and lower branch of splitting ban ds,respectively.And screening effect from substrate is shown to substa ntially impact onthe electronic properties.Our results provide importa nt insights into band structure engineering in mono layer TMDs.Our mono layer WSe2 crystals may constitute a valuable device platform. | Wenjuan Zhao Yuan Huang Cheng Shen Cong Li Yongqing Cai Yu Xu Hongtao Rong Qiang Gao Yang Wang Lin Zhao Lihong Bao Qingyan Wang Guangyu Zhang Hongjun Gao Zuyan Xu Xingjiang Zhou Guodong Liu | 2019 | Nano Research2019，12，12： | 2 |
| 12 | A critical review of extracellular polymeric substances (EPSS) in membrane bioreactors: Characteristics, roles in membrane fouling and control strategies 显示文摘 | LIN Hongjun ZHANG Meijia WANG Fangyuan | 2014 | Journal of Membrane Science2014，460，11： | 1 |
| 13 | Fea- sibility evaluation of submerged anaerobic membrane bioreac- tor {or municipal secondary wastewater treatment显示文摘 | LIN Hongjun CHEN Jianrong WANG Fangyuan | 2011 | Desali- nation2011，280，123： | 1 |
| 14 | Enhanced performance of a submerged membrane bioreactor with powdered activated carbon addition for municipal secondary effluent treatment显示文摘 | Lin Hongjun Wang Fangyuan Ding Linxian | 2011 | Journal of Hazardous Materials2011，192，3： | 1 |
| 15 | Synthesis and characterization of melt-processable polyimides derived from 1,4-bis(4-amino-2-trifluoromethyiphenoxy) benzene显示文摘 | Zuo Hongjun Chen Jiansheng Fan Lin | 2008 | Journal of Applied Polymer Science2008，107，： | 1 |
| 16 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 17 | Factors affecting THMs, HAAs and HNMs formation of Jin Lan Reservoir water exposed to chlorine and monochloramine显示文摘 | Huachang Hong Yujing Xiong Mengyong Ruan Fanglei Liao Hongjun Lin Yan Liang | 2013 | Science of the Total Environment2013，，： | 1 |
| 18 | A biobased flame retardant towards improvement of flame retardancy and mechanical property of ethylene vinyl acetate显示文摘A new biobased flame retardant(MHPA)with remarkable compatibility was synthesized via a facile and low-cost neutralization reaction of magnesium hydroxide(MH)and phytic acid(PA).By blending the prepared MHPA into ethylene vinyl acetate(EVA),the fire retardancy,smoke suppression and mechanical properties of the composites were significantly improved.When 50 wt%of MH was added into EVA matrix,the value of limiting oxygen index(LOI)reached 26.1%.Whereas,when 10 wt%MH in the EVA composites(with initial 50 wt%MH)was replaced by MHPA,the resulted EVA composites had a LOI value of 30.8%,indicating high efficiency of addition of MHPA to improve flame retardancy.Moreover,the heat release rate(HRR)and total smoke production(TSP)of the EVA composites reduced by 54.4%and 27.6%,respectively,suggesting that incorporation of MHPA could effectively hinder rapid degradation of EVA composites during burning process.The fire-retardant mechanism may reside in that the MHPA combined with MH can present the excellent carbonization and expansion effects.This study illustrates that the biobased MHPA has a broad application prospect to develop flame-retardant EVA composites. | Siyi Xu Yue Han Cheng Zhou Jianxi Li Liguo Shen Hongjun Lin | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 19 | Enhanced performance of a submerged membrane bioreactor with powdered activated carbon addition for municipal secondary effluent treatment显示文摘 | LIN Hongjun WANG Fangyun DING Linxian | 2011 | Journal of Hazardous Materials2011，152，： | 1 |
| 20 | Phytoplankton pigment pattern in the subsurface chlorophyll maximum in the South Java coastal upwelling system, Indonesia显示文摘Upwelling occurs on the coast of Java between June and October, forced by local alongshore winds associated with the southeasterly monsoon. This causes variations in phytoplankton community composition in the upwelling zone compared with the surrounding offshore area. Based on pigments analysis with subsequent calculations of group contributions to total chlorophyll a(Chl a) using CHEMTAX, we studied the distribution and composition of phytoplankton assemblages in the subsurface chlorophyll maximum along the south coast of Java and the influence of upwelling. Nineteen phytoplankton pigments were identified using high-performance liquid chromatography, and CHEMTAX analysis associated these to ten major phytoplankton groups. The phytoplankton community in the coastal area influenced by upwelling was characterized by high Chl a and fucoxanthin concentrations, indicating the dominance of diatoms. In contrast, in the offshore area, the Chl a and fucoxanthin concentrations declined to very low levels and the community was dominated by haptophytes represented by 19′-Hexanoyloxyfucoxanthin. Accordingly, microphytoplankton was found to be the major size class in the coastal area influenced by upwelling, while nanophytoplankton was most abundant in the offshore area. Low concentrations of other accessory pigments indicated less contribution from dinoflagellates,prasinophytes, chlorophytes and cryptophytes. Photo-pigment indices revealed that photosynthetic carotenoids(PSCs) were the largest component of the pigment pool, exceeding the proportion of Chl a, with the average PSCTP up to 0.62. These distribution trends can mainly be explained by phytoplankton adaption strategies to upwelling and subsurface conditions by changing species composition and adjusting the pigment pool. | GAO Chunlei FU Mingzhu SONG Hongjun WANG Lei WEI Qinsheng SUN Ping LIU Lin ZHANG Xuelei | 2018 | Acta Oceanologica Sinica2018，37，12： | 1 |
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